Recombinant Rabbit Ryanodine receptor 1 (RYR1), partial

1. In-depth structural analyses elucidated a novel channel-gating mechanism and a novel ion selectivity mechanism of RyR1. PMID: 27573175
2. the cryo-electron microscopy structures of rabbit RyR1 in three closed conformations at about 4 A resolution and an open state at 5.7 A, are reported. PMID: 27468892
3. Data suggest that RyR1 exhibits conformation consistent with an open-channel model sufficient for movement of Ca2+ except for a pore constriction site; molecular dynamics simulations suggest Ca2+ passage could be allowed by rotation of upper portion of pore-lining S6 helix away from 4-fold channel axis and twisting of Ile-4937 at channel constriction site out of the channel pore. PMID: 28584051
4. Data suggest that reduced SOICR (store overload-induced Ca2+ release) threshold is a common defect of malignant hyperthermia- or central core disease-associated RyR1 mutations; carvedilol (a beta-blocker), like dantrolene (a central muscle relaxant), can suppress RyR1-mediated SOICR. Here, human disease-associated point mutations were induced in recombinant rabbit RyR1 via site-directed mutagenesis. PMID: 28687594
5. RyR1-G4934A had reduced K(+) conductance and ion selectivity compared with WT. Mutations further increasing the side chain volume at these positions (G4934V and G4941I) resulted in reduced caffeine-induced Ca(2+) release. PMID: 25998124
6. Structural insights into the roles of divergent regions in RyR1 allosteric regulation during excitation contraction coupling. PMID: 25132084
7. architecture of rabbit RyR1 at a resolution of 6.1 A, using electron cryomicroscopy PMID: 25470059
8. closed-state structure of the 2.3-megadalton complex of the rabbit skeletal muscle type 1 RyR (RyR1), solved by single-particle electron cryomicroscopy at an overall resolution of 4.8 A PMID: 25470061
9. Diminishing S-palmitoylation directly suppresses RyR1 activity as well as stimulus-coupled Ca(2+) release through RyR1. PMID: 24509862
10. Two regions of the ryanodine receptor calcium channel are involved in Ca(2+)-dependent inactivation PMID: 24521037
11. Data indicate that S107 increased FKBP12 binding to RyR1 in sarcoplasmic reticulum vesicles in the presence of reduced glutathione and the NO-donor NOC12. PMID: 23349825
12. These results suggest that the intersubunit contact region between N-terminal domains of RyR1 is a prime target for disease mutations. PMID: 23422674
13. Sequence data of the ATP binding regions of the RyR1 protein was presented. PMID: 23144945
14. a 2.2 A resolution crystal structure of the RyR domain revealing a two-fold, symmetric, extended four-helix bundle stabilized by a beta sheet. PMID: 22913516
15. Coupled events reveal complex interactions among RyR1, differentially modulated by cytosolic ATP/Mg2+ and Ca2+ under ionic conditions. PMID: 22785120
16. 3D localization of a SPRY2 domain in RYR1 PMID: 21998699
17. Both basic and acidic amino acid residues of IpTx(a) are involved in triggering substate of RyR1. PMID: 22007141
18. Chloroform extract of hog barn dust modulates skeletal muscle ryanodine receptor calcium-release channel (RyR1). PMID: 20576841
19. RyRsl subunit is expressed in corpus cavernosum smooth muscle cells. PMID: 16524180
20. phosphorylation and K201 acted similarly to change the conformation of RyR1/2 and regulate FKBP12/12.6 binding. PMID: 19661110

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KEGG: ocu:100009540

UniGene: Ocu.2092