Recombinant Rat Caveolin-3(Cav3)

Code CSB-YP004573RA
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Source Yeast
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Code CSB-EP004573RA
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Source E.coli
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Code CSB-EP004573RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004573RA
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Source Baculovirus
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Code CSB-MP004573RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Cav3
Uniprot No. P51638
Alternative Names Cav3Caveolin-3
Species Rattus norvegicus (Rat)
Expression Region 1-151
Target Protein Sequence MMTEEHTDLE ARIIKDIHCK EIDLVNRDPK NINEDIVKVD FEDVIAEPEG TYSFDGVWRV SYTTFTVSKY WCYRLLSTLL GVPLALLWGF LFACISFCHI WAVVPCIKSY LIEIQCISHI YSLCIRTFCN PLFAALGQVC SNIKVVLRRE G
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.
Gene References into Functions
  1. Cav3 depletion in cardiac fibroblasts induced an increase in collagen content, cell proliferation, and phenotypic conversion of fibroblasts to myofibroblasts. Conversely, Cav3 overexpression in cardiac fibroblasts was shown to inhibit angiotensin II-mediated excessive collagen deposition through protein kinase C-epsilon inactivation. PMID: 29486470
  2. Antioxidant N-acetylcysteine attenuated myocardial dysfunction and myocardial I/R injury by improving Cav-3/eNOS signaling. PMID: 27733157
  3. Hypoxic preconditioning promotes the translocation of protein kinase C epsilon binding with caveolin-3 at cell membrane, not at mitochondrial one, in rat heart. PMID: 26313243
  4. miR-22 down-regulated Cav3, leading to restored eNOS activity/NO production, which inhibited cardiac myocyte apoptosis and promoted cardiac function after myocardial ischemia and reperfusion. PMID: 26191152
  5. MURC/cavin-4 requires its coiled-coil domain to target the plasma membrane and to stabilize Cav3 at the plasma membrane of cardiomyocytes PMID: 26497963
  6. HLP forms a triple complex with RyR2 and caveolin-3. siRNA and adenovirus-mediated KD of HLP decreased the electrically evoked Ca(2+) release from the sarcoplasmic reticulum PMID: 26071359
  7. PKCbeta2 inhibition protects diabetic hearts from myocardial ischemia/reperfusion injury through Cav-3-dependent activation of Akt. PMID: 25849791
  8. statin treatment can reduce caveolin 3 expression, with functional consequences consistent with the known role of caveolae in the cardiac cell. PMID: 25211146
  9. Cav-3 plays an important role in the stimulation of calcium signaling by PKA-induced phosphorylation at the t-tubules. PMID: 24412535
  10. Hormonal alteration causes a significant change in the expression of caveolin 2 and 3 in smooth muscle of rat urinary bladder. PMID: 24040945
  11. Expression of caveolin-3 siRNA stimulated angiotensinogen expression in cardiac myocytes. PMID: 23058350
  12. Data indicate that Gja1, Cav3 and Kcnk3 were up-regulated and Hcn2 was down-regulated in hearts of exercise trained Goto-Kakizaki (GK) type 2 diabetic rat compared to sedentary GK controls. PMID: 23620341
  13. hERG expression in the plasma membrane is regulated by Cav3 via Nedd4-2 PMID: 22879586
  14. caveolin-3 protein expression and immunoreactivity were reduced in bladder smooth muscle at 6, 12 and 19 months of age compared with young animals. PMID: 22374691
  15. Estrogen attenuates the hypertrophic response induced by pressure overload through down-regulation of extracellular signal-regulated kinases 1/2 phosphorylation and up-regulation of caveolin-3 expression. PMID: 21170593
  16. investigation of mechanisms in matricine signaling: up-regulation of Cav3 plays a role in extracellular matrix (i.e., laminin) stimulation of pituitary folliculostellate cell proliferation PMID: 21508095
  17. Caveolin-3 plays an important role in the mechanism by which 17 beta-estadiol attenuates diet-induced glucose intolerance. PMID: 20953984
  18. Depletion of Cav3 induced by delivery of the dominant-negative Cav3 (P104L) form impairs myoblast differentiation via Akt and p38 signalling networks, leading to an immature cell and molecular signature. PMID: 21182936
  19. association between VDR and caveolin-3 and the regulation of this interaction by 1,25(OH)2D3 are fundamentally important in understanding 1,25(OH)2D3 signal transduction in heart cells PMID: 20304057
  20. Suggest that caveolin is an important regulator of glucose metabolism that can enhance insulin signals and improve glucose metabolism in diabetic mice. PMID: 19923424
  21. Cardiac caveolin-3 is identified as juxtamembrane scaffolding for estrogen receptor alpha docking at caveolae, which provide a unique compartment for conveying 17beta-estradiol-elicited, rapid signaling to regulate connexin43 phosphorylation. PMID: 19523531
  22. detected by Western blot analysis and immunofluorescence microscopy of isolated sinus endothelial cells and tissue cryosections of the spleen PMID: 11904769
  23. estradiol reduces the association of cardiac eNOS with the inhibitory protein caveolin-3 PMID: 12003841
  24. caveolin-3-caveolin-2 interactions may play a role in caveolae biogenesis and influence cardiac muscle physiology PMID: 12649076
  25. Expression of caveolin-3 in aortic vascular smooth muscle cells is determined by the state of cell differentiation. PMID: 12705878
  26. Cav-3 protein expression is increased in the failing myocardium. NOS1, confined to the sarcolemma, interacts with Cav-3. Increased Cav-3-associated NOS1 could constitute an increased pool of enzyme available for activation on stimulation. PMID: 15466641
  27. Caveolin-3 is expressed constitutively in some astrocytes, but not in endothelial cells; its immunoreactivity is increased in reactive astrocytes in experimental autoimmune encephalomyelitis lesions. PMID: 15925413
  28. The distribution of G-protein-coupled receptors (GPCR), G-proteins, and adenylate cyclase with caveolin-3 in sarcolemmal and intracellular regions suggests multiple Cav-3-localized microdomains for signaling by hormones and drugs in the heart. PMID: 15961389
  29. Caveolin-3 is adjacent to a group of extradyadic ryanodine receptors PMID: 15980179
  30. A redistribution of caveolin-3 in the light fractions of myocardium occurred after 10 min of reperfusion PMID: 16565301
  31. caveolin-3 is responsible for keeping endothelial nitric oxide synthase in a membrane compartment in the apical region of ciliated cells PMID: 17123860
  32. Suggest that Cav3 expression, which is closely related to added functional stimuli, reflects the differentiation of the type B synoviocytes. PMID: 18286598
  33. This study found that CAV-3 immunoreactivities (IRs) were Localized in the myelin sheath during peripheral nerve development. CAV-3 IRs were intense during the early postnatal stage, but decreased as the peripheral nerves matured at postnatal weeks 3-5. PMID: 18720574
  34. Confocal immunofluorescence microscopy shows that caveolin-3 is present throughout the t-tubule system in skeletal muscle fibers, with 'hot-spots' at the necks of the tubules in the sub-sarcolemmal space. PMID: 19101541
  35. Report colocalization of K(ATP) channel pore-forming subunit Kir6.2 and caveolin-3 along the cardiac myocyte plasma membrane. PMID: 19181933

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Subcellular Location Golgi apparatus membrane, Peripheral membrane protein, Cell membrane, Peripheral membrane protein, Membrane, caveola, Peripheral membrane protein, Cell membrane, sarcolemma
Protein Families Caveolin family
Tissue Specificity Expressed predominantly in muscle.
Database Links

KEGG: rno:29161

STRING: 10116.ENSRNOP00000007601

UniGene: Rn.98191

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