Recombinant Rat Kappa-type opioid receptor (Oprk1), partial

1. Pre- and postsynaptic colocalization of kappa opioid receptor and D2R supports a role for kappa opioid receptor potentiating both the D2R inhibitory autoreceptor function and the inhibitory action of D2R on efferent medium spiny neurons. Kappa opioid receptor co-activation accelerates D2R sensitization by contributing to decrease dopamine release in the nucleus accumbens. PMID: 28531297
2. Using selective agonists and antagonists showed that kappa-opioid receptor stimulation normalizes endothelial ultrastructure and function under hyperlipidemic condition. Its mechanism is related to the preservation of eNOS phosphorylation through activation of the PI3K/Akt signaling pathway and downregulation of iNOS expression/activity. PMID: 27226238
3. These data suggest that kappa opioid receptors may have increased responsiveness following social isolation, which could lead to hypodopaminergia and contribute to an increased drive to consume ethanol. PMID: 26860203
4. Hypertension increased the expression of Kappa Opioid receptors and heterodimerization of apelin receptors and Kappa Opioid receptors, and reduced pERK1/2 in the left ventricle. PMID: 28987634
5. triazole 1.1 retained the antinociceptive and antipruritic efficacies of a conventional KOR agonist, yet it did not induce sedation or reductions in dopamine release in mice, nor did it produce dysphoria as determined by intracranial self-stimulation PMID: 27899527
6. This is the first study to provide compelling evidence for a novel and unique neuromodulatory role for Kappa opioid receptors. PMID: 28163104
7. Suggest that mixed cardiac ion channel blockade my mediated the antiarrhythmia actions of kappa-opioid receptor antagonist PD117,302. PMID: 26086860
8. In conclusion, kappa-opioid receptors in the IL modulate pressor and tachycardiac responses caused by RS, suggesting a facilitatory role of this structure in this aversive situation. PMID: 25641629
9. A brief stressor produces changes in the reward circuitry lasting several days. Our findings reveal roles for glucocorticoid receptors and kappaORs as mediators of the lasting effects of stress on synaptic plasticity. PMID: 24957331
10. This study demonistrated that Oprk1 and Melanin-concentrating hormone colization in neuron in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed throughout the brain. PMID: 24978951
11. These results, along with those reported previously, suggested that morphine dependence may be associated with regionally specific changes in kappa-opioid receptor expression in mesocorticolimbic system. PMID: 24219160
12. kappa opioid receptor is reduced in stressed subjects, but does not contribute to age differences in ethanol-induced conditioned taste aversion. PMID: 23276674
13. the present study demonstrates the importance of k-ORs in the attenuation of pulmonary artery hypertension during hypoxia. PMID: 23838631
14. Negative affective states induced by alcohol withdrawal are induced in part by kappa-opioid receptors. PMID: 23212453
15. Systemic activation of mu-receptors, but not delta- or kappa-receptors, is able to switch rapid- to shallow-breathing rats into a long-lasting apneic state. PMID: 22796630
16. Kappa-opioid receptors influence the stretch-induced electrophysiological changes and play an antiarrhythmic role in cardiac arrhythmia following myocardial infarction. PMID: 22735633
17. The kappa opioid receptor system is involved in regulating stress-related behaviors associated with ethanol. PMID: 22487769
18. Activation of peripheral KORs directly blocks inflammatory hyperalgesia through stimulation of the nNOS/NO signaling pathway which is probably stimulated by PI3Kgamma/AKT signaling. PMID: 22316281
19. data suggest that DOR-KOR heteromers exist in rat primary sensory neurons and that KOR antagonists can act as modulators of DOR agonist responses most likely through allosteric interactions between the protomers of the DOR-KOR heteromer PMID: 22072818
20. Dysregulation of kappa-opioid receptor systems contributes to the excessive self-administration observed in alcohol dependent animals. PMID: 21338616
21. The results of this study suggested that recovery from immobilization stress may alter striatal oprk1 mrna in male rats. PMID: 21723305
22. findings suggest that fear conditioning and extinction dynamically regulate KOR expression in the BLA. PMID: 21531393
23. Reduction of kappa-opioid receptor (KOR)/ mu-opioid receptor (MOR) by estrogen receptor blockade or spinal aromatase inhibition shifts spinal morphine antinociception from KOR dependent to KOR independent. PMID: 21849544
24. provided evidence for mRNA transport and regulation of presynaptic protein synthesis of nonstructural proteins like KOR in primary sensory neurons [kappa-opioid receptor] PMID: 17167054
25. The kappa-opioid receptor system does not function in an adult-like manner during the late preweanling period. A possible explanation is that the coupling between kappa-opioid receptors and their second messengers are not fully mature by PD 17. PMID: 20435099
26. The nucleus accumbens and piriform cortex are identified as brain regions in which modifications in KOR function may differentiate the Wistar Kyoto strain from Sprague Dawley rats. PMID: 19924112
27. phosphorylation of serine 369 mediates KOR desensitization and internalization PMID: 12815037
28. Long-term effects on brain opioid receptor(kappa) after short periods of maternal separation in rats. PMID: 12842289
29. Immunoblotting analysis of kappa-opioid receptors from butorphanol-withdrawal rats showed significant increases in 11 of 21 brain regions examined. PMID: 14580956
30. both negative and positive functional interaction between delta, mu and kappa opioid receptors regulate the influence of MET on H(2)O(2) and NO production in rat peritoneal macrophages. PMID: 15467355
31. Oprk1 is expressed in the cerebellar cortex. PMID: 15778854
32. Our results point to an involvement of KOR and nNOS in the same intracellular network that controls the development of morphine tolerance and dependence. PMID: 15950775
33. Regional changes in the mRNA for and protein levels of the kappa-opioid receptor focus attention on highly special roles for this receptor in the development of physical dependence on and the expression of withdrawal from butorphanol dependence. PMID: 16130146
34. endogenous opioids modulate the pressor response to intracerebral AngII; this effect is mediated mainly through endogenous Oprk1 agonists rather than Oprm1; alteration of baroreceptor sensitivity by angII is modulated by endogenous kappa opioids. PMID: 17980907
35. kappa-ORs afford cardioprotection primarily when activated prior to and not after reperfusion PMID: 18500486
36. These data add to the growing literature showing that kappa opioid receptors can modulate diverse afferent signaling to the locus caeruleus. PMID: 19009591
37. the antidipsogenic effect observed in rats following third ventricle injections of IL-1beta depend on the functional integrity of a brain kappa-opioid-dependent component. PMID: 19217659
38. The present study has provided evidence for the first time of the precise location of kappa-ORs in PAs and PASMCs of rats and that hypoxia upregulates expression of kappa-ORs. PMID: 19462402
39. the kappa-opioid receptor in the anteroventral preoptic region is important for the reduction of body temperature during hypoxia PMID: 19545549
40. findings suggest that antinociception induced by activation of kappa opioid receptors in the TMJ region is mediated by the L-arginine/NO/cGMP pathway in both sexes PMID: 19567249

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KEGG: rno:29335

STRING: 10116.ENSRNOP00000010255

UniGene: Rn.89571