Recombinant Rat Metabotropic glutamate receptor 3 (Grm3), partial

1. Results indicate a double function for glial mGlu3R activation against Abeta neurotoxicity: (i) it increases the release of protective neurotrophins such as sAPPalpha and BDNF, and (ii) it induces amyloid removal from extracellular space by glia-mediated phagocytosis. PMID: 28495373
2. Following activation of mGluR3 receptors in prefrontal cortex, sensory motor gating deficits were reversed. PMID: 24067361
3. An inflammatory environment triggers an opposite gene expression regulation of two predominant subtypes, mGluR3 and mGlur5, found in glial cells. PMID: 22245498
4. New evidence for the antiparkinsonian efficiency of group III mGlu receptor agonism points to the regulation of the overactive subthalamo-nigral connection as a main site of action in an early stage of Parkinson's disease. PMID: 22245662
5. Data suggest that ezrin is required for the structural plasticity of PAPs and mGluRs can stimulate PAP plasticity. PMID: 21753079
6. group 3 mglurs increase gaba release from the posterior pituitary PMID: 12098644
7. Modulation of short-term plasticity by activation of group III metabotropic glutamate receptors (mGluR) was investigated in the lateral perforant path of the dentate gyrus PMID: 12363402
8. mGluR3 can modulate high potassium, low calcium-induced spontaneous epileptiform burst activity in acute rat hippocampal slice dentate granule cells. PMID: 12694929
9. Binding of [3H]DCG-IV to rat mGlu3 in human kidney cells is very sensitive to mutagenesis-induced perturbations. These findings define essential features of the ligand-binding pocket of mGlu3 and provide opportunities for structure-based drug design PMID: 12887692
10. distinct functions for mGluR2 and mGluR3 and dynamic regulation of mGluR3 by PP2C PMID: 14663150
11. role of glutamate carboxypeptidase II inhibition in preventing programmed cell death in neurons exposed to high glucose; this neuroprotection is mediated through the mGluR3 receptor, most likely by increasing the extracellular NAAG concentration PMID: 15030392
12. data suggest an essential role for mGluR3 in long-term depression , and a modulatory role for mGluR3 in long-term potentiation PMID: 15635057
13. Activation of a group III mGluR in bone marrow stromal cells inhibits a Ca(2+)-permeable plasma membrane channel, reducing [Ca(2+)](i) and suppressing generation of NO. PMID: 15799084
14. mGluR autoreceptors function to change the synaptic state and distribute metabolic demand, rather than to depress synaptic amplitude PMID: 15845577
15. mGluR3 is coupled to cGMP levels and that mGluR3-induced reduction of cGMP levels is mediated by different G proteins in cerebellar astrocytes and neurons. PMID: 16417588
16. we explore whether mGluR3 expression is affected in a rat model of temporal lobe epilepsy PMID: 16793029
17. Pharmacological activation of group II mGluRs such as mGluR2 modifies both stress- and cue-induced ethanol-seeking. PMID: 17005860
18. Our results demonstrate that stimulation of group III mGluRs in the striatum, GP or SNr exerts antiparkinsonian-like effects in rats. PMID: 17224239
19. These results support the conclusions that activating glial mGluR3 protects neurons from glucose-induced oxidative injury by increasing free radical scavenging and stabilizing mitochondrial function, through increased GSH antioxidant defense. PMID: 17402968
20. We suggest that the concurrent depression of action potential-evoked, and enhancement of action potential-independent glutamate release operate through discrete second messenger/effector systems at excitatory entorhinal terminals in rat brain. PMID: 17630217
21. Posttraumatic secondary brain insults exacerbate neuronal injury by altering expression of metabotropic glutamate receptors. PMID: 18021417
22. These data confirm that activation of group III mGlu receptors inhibits GABA release in the globus pallidus, thereby supporting their hetero-receptor role in vivo. PMID: 18035348
23. These data indicate a long-lasting impairment of mGlu2/3 expression that may contribute to abnormal presynaptic plasticity, exaggerate glutamate release and hyperexcitability in temporal lobe epilepsy PMID: 18804094
24. The expression, purification, crystallization and preliminary X-ray crystallographic analysis of mGluR3 extracellular domain, is reported. PMID: 19255473
25. The present study aimed to examine the role of mGluR3/mGluR7 in lead-induced neurotoxicity. PMID: 19374778

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KEGG: rno:24416

STRING: 10116.ENSRNOP00000007572

UniGene: Rn.41715