Recombinant Rat Metabotropic glutamate receptor 3 (Grm3), partial

Code CSB-YP009933RA
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP009933RA
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP009933RA-B
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP009933RA
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP009933RA
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Grm3; Gprc1c; Mglur3Metabotropic glutamate receptor 3; mGluR3
Rattus norvegicus (Rat)
Protein Length
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Gene References into Functions
  1. Results indicate a double function for glial mGlu3R activation against Abeta neurotoxicity: (i) it increases the release of protective neurotrophins such as sAPPalpha and BDNF, and (ii) it induces amyloid removal from extracellular space by glia-mediated phagocytosis. PMID: 28495373
  2. Following activation of mGluR3 receptors in prefrontal cortex, sensory motor gating deficits were reversed. PMID: 24067361
  3. An inflammatory environment triggers an opposite gene expression regulation of two predominant subtypes, mGluR3 and mGlur5, found in glial cells. PMID: 22245498
  4. New evidence for the antiparkinsonian efficiency of group III mGlu receptor agonism points to the regulation of the overactive subthalamo-nigral connection as a main site of action in an early stage of Parkinson's disease. PMID: 22245662
  5. Data suggest that ezrin is required for the structural plasticity of PAPs and mGluRs can stimulate PAP plasticity. PMID: 21753079
  6. group 3 mglurs increase gaba release from the posterior pituitary PMID: 12098644
  7. Modulation of short-term plasticity by activation of group III metabotropic glutamate receptors (mGluR) was investigated in the lateral perforant path of the dentate gyrus PMID: 12363402
  8. mGluR3 can modulate high potassium, low calcium-induced spontaneous epileptiform burst activity in acute rat hippocampal slice dentate granule cells. PMID: 12694929
  9. Binding of [3H]DCG-IV to rat mGlu3 in human kidney cells is very sensitive to mutagenesis-induced perturbations. These findings define essential features of the ligand-binding pocket of mGlu3 and provide opportunities for structure-based drug design PMID: 12887692
  10. distinct functions for mGluR2 and mGluR3 and dynamic regulation of mGluR3 by PP2C PMID: 14663150
  11. role of glutamate carboxypeptidase II inhibition in preventing programmed cell death in neurons exposed to high glucose; this neuroprotection is mediated through the mGluR3 receptor, most likely by increasing the extracellular NAAG concentration PMID: 15030392
  12. data suggest an essential role for mGluR3 in long-term depression , and a modulatory role for mGluR3 in long-term potentiation PMID: 15635057
  13. Activation of a group III mGluR in bone marrow stromal cells inhibits a Ca(2+)-permeable plasma membrane channel, reducing [Ca(2+)](i) and suppressing generation of NO. PMID: 15799084
  14. mGluR autoreceptors function to change the synaptic state and distribute metabolic demand, rather than to depress synaptic amplitude PMID: 15845577
  15. mGluR3 is coupled to cGMP levels and that mGluR3-induced reduction of cGMP levels is mediated by different G proteins in cerebellar astrocytes and neurons. PMID: 16417588
  16. we explore whether mGluR3 expression is affected in a rat model of temporal lobe epilepsy PMID: 16793029
  17. Pharmacological activation of group II mGluRs such as mGluR2 modifies both stress- and cue-induced ethanol-seeking. PMID: 17005860
  18. Our results demonstrate that stimulation of group III mGluRs in the striatum, GP or SNr exerts antiparkinsonian-like effects in rats. PMID: 17224239
  19. These results support the conclusions that activating glial mGluR3 protects neurons from glucose-induced oxidative injury by increasing free radical scavenging and stabilizing mitochondrial function, through increased GSH antioxidant defense. PMID: 17402968
  20. We suggest that the concurrent depression of action potential-evoked, and enhancement of action potential-independent glutamate release operate through discrete second messenger/effector systems at excitatory entorhinal terminals in rat brain. PMID: 17630217
  21. Posttraumatic secondary brain insults exacerbate neuronal injury by altering expression of metabotropic glutamate receptors. PMID: 18021417
  22. These data confirm that activation of group III mGlu receptors inhibits GABA release in the globus pallidus, thereby supporting their hetero-receptor role in vivo. PMID: 18035348
  23. These data indicate a long-lasting impairment of mGlu2/3 expression that may contribute to abnormal presynaptic plasticity, exaggerate glutamate release and hyperexcitability in temporal lobe epilepsy PMID: 18804094
  24. The expression, purification, crystallization and preliminary X-ray crystallographic analysis of mGluR3 extracellular domain, is reported. PMID: 19255473
  25. The present study aimed to examine the role of mGluR3/mGluR7 in lead-induced neurotoxicity. PMID: 19374778

Show More

Hide All

Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 3 family
Tissue Specificity
Is widely distributed in the CNS. Predominant expression is seen in the neuronal cells of the cerebral cortex, dentate gyrus, and glial cells throughout brain regions.
Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1