Recombinant Rat Receptor tyrosine-protein kinase erbB-4(Erbb4),partial

Code CSB-YP733850RA
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Source Yeast
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Code CSB-EP733850RA
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Source E.coli
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Code CSB-EP733850RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP733850RA
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Source Baculovirus
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Code CSB-MP733850RA
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Erbb4; Tyro-2; Receptor tyrosine-protein kinase erbB-4; EC; Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain; 4ICD; E4ICD; s80HER4)]
Rattus norvegicus (Rat)
Protein Length
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis.
Gene References into Functions
  1. It is a member of the receptor tyrosine kinase family, plays critical roles in development and function of neural circuitry, relevant to behavioral deficits. PMID: 29674181
  2. ErbB4 plays a neuroprotective role in early brain injury after subarachnoid hemorrhage. PMID: 28756200
  3. The Paracrine Effect of Skeletal Myoblasts Is Cardioprotective Against Oxidative Stress and Involves EGFR-ErbB4 Signaling, Cystathionase, and the Unfolded Protein Response PMID: 26021843
  4. NRG-1, ErbB2, and ErbB4 expression significantly decreased in vein grafts over time. PMID: 25978692
  5. Findings reveal an intimate reciprocal relationship between ErbB4 and GluN2b NMDA receptors via NRG2/ErbB4 signaling. PMID: 26027736
  6. Exercise training and return to a well-balanced diet activate the neuregulin 1/ErbB pathway in skeletal muscle of obese rats PMID: 25820551
  7. These results indicate that ecto-ErbB4 could be used in vivo as a tool to manipulate the neuregulin1/ErbB system. PMID: 25177687
  8. Data show that each of the four ErbB4 isoforms is able to confer cells with an adhesion preference for cells expressing the transmembrane neuregulin 1 type III PMID: 24518229
  9. ErbB4 reduces synaptic GABAA currents independent of its receptor tyrosine kinase activity. PMID: 24218551
  10. neuregulin-1/ErbB signaling plays an important role in central remyelination under pathological conditions and contributes to the alleviation of pain. PMID: 23097328
  11. NMDA receptor antagonism early in life can have long term effects on neuregulin (Nrg)1/erbB4 expression which could be important in understanding pathological processes that might be involved in schizophrenia. PMID: 21962913
  12. NRG1 stimulation of the ErbB4 receptor exerts a sustained divalent calcium-ion increase in a neural progenitor cell line. PMID: 21991932
  13. A role for NRG1 and ERBB4-4ICD signaling in the regulation of gene expression contributes to normal and schizophrenic neuronal function. PMID: 21352860
  14. Thus ErbB4 localizes to the nucleus as a full-length protein, and plays a role in the DNA damage response induced by doxorubicin in cardiac myocytes. PMID: 22244893
  15. AAK1 is a relevant target of K252a, that the loss of AAK1 alters ErbB4 trafficking and expression levels, providing evidence for a previously unrecognized role for AAK1 in Nrg1-mediated neurotrophic factor signaling. PMID: 21802010
  16. Suggest that the up-regulation of miR-146a after doxorubisin (Dox) treatment is involved in acute Dox-induced cardiotoxicity by targeting ErbB4. PMID: 20495188
  17. Data showed that NRG1beta and ErbB4 expressions were significantly increased in the rat prefrontal cortex and hippocampus in rat schizophrenia model. Findings suggest that altered expressions of NRG1 and ErbB4 might be attributed to the schizophrenia. PMID: 20467458
  18. Expression of ErbB2 and ErbB4 receptor mRNA is down-regulated in myocardial infarction. PMID: 18705011
  19. ErbB4 may participate in tooth morphogenesis PMID: 12112465
  20. Early onset and preferential expression of ErbB4 in tangentially migrating interneurons suggests that neuregulin receptor ErbB4 signaling may regulate the development and function of telencephalic interneurons. PMID: 12571115
  21. Neuregulin stimulation causes translocation of ErbB4 into lipid rafts and these are necessary for signaling by ErbB4 PMID: 12716924
  22. Testicular acid phosphatase acts as a tyrosine phosphatase to modulate signals mediated by ErbB4 that are important for neuronal development and synaptic plasticity. PMID: 15219672
  23. ErbB4 signaling via PI3K activation plays a fundamental role in controlling NRG1beta1-induced migration PMID: 15355992
  24. The functional significance for cell volume regulation of the ErbB4-Src-PI3K signaling cascade is indicated by the 48-66% decrease of the hyposmotic taurine efflux observed by inhibition of these kinases. PMID: 15934939
  25. Neuregulin mediates survival of PC12-ErbB-4 cells from apoptosis induced by serum deprivation, tumor necrosis factor-alpha treatment, or hydrogen peroxide. PMID: 15968086
  26. ErbB4 receptors when activated by neuregulin play an important role in neuron survival after MPP+ treatment. This requires PI3K/PKB/Akt and Ras/MapK signaling networks. PMID: 17085783
  27. ErbB4 endocytosis plays a role in neuregulin-1 signaling in neurons. PMID: 17250808
  28. erbB4 is an important receptor in the control of fetal lung type II cell maturation PMID: 17545485
  29. Results describe the regulation of ErbB-4 endocytosis by neuregulin in GABAergic hippocampal interneurons. PMID: 17562386
  30. Taken together, these results show that ErbB4 is expressed by neuronal somatodendrites in cerebral cortex and hippocampus from birth to adulthood, and support a role for neuregulins in dendritic growth and plasticity. PMID: 17630218
  31. ErbB4 isoform that is proteinase cleavable but does not contain a PI3K-binding domain in its cytoplasmic tail, mediates important functions in renal epithelial cells in response to HB-EGF PMID: 17761534
  32. NRG1/ErbB4 signaling differentially regulates synapse maturation and dendritic morphology via two distinct mechanisms involving trans-synaptic signaling and tyrosine kinase activity, respectively PMID: 18819924
  33. Data show that the expression of ErbB4 mRNAs is downregulated after end-to-end and end-to-side nerve regeneration in the rat median nerve model. PMID: 18845940
  34. ventricular ErbB2 and ErbB4 receptors become activated during the development of pacing-induced heart failure, but downstream signaling is partly abrogated PMID: 19010331
  35. The authors conclude that ErbB4 participates in maintaining adult lung alveolar epithelial cell surfactant synthesis and proliferation with development-specific functions. PMID: 19191103

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
Tissue Specificity
Preferentially expressed in the developing nervous system. Exhibits distinct and highly regionalized patterns of expression in the adult brain, where it is mainly found in the reticular nucleus of the thalamus. Very low levels in kidney, and heart.
Database Links
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