Recombinant Rat Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (Atp2a1), partial

1. In acute stages of sepsis, the improvement of SERCA function could reduce the disequilibrium of calcium homeostasis to improve the critical illness myopathy and respiratory failure. PMID: 28765908
2. This study demonstrated that Slowed relaxation of the diaphragm in septic rats was associated with reduced expression of SERCA1. PMID: 27104787
3. SERCA has a role in sarcoplasmic reticulum calcium content and calcium wave propagation in rat ventricular myocytes PMID: 27242324
4. these results suggest that sAnk1 interacts with SERCA1 through its TM and cytoplasmic domains to regulate SERCA1 activity and modulate sequestration of Ca(2+) in the sarcoplasmic reticulum lumen. PMID: 26405035
5. Thus the human SERCA1b has a different expression pattern from that of rodents and it is associated with DM2. PMID: 25487304
6. changes between enzyme activity and fluorescence isothiocyanate binding suggest that, at least during recovery after exercise, changes in SERCA activity may not correlate with structural alterations to the adenine nucleotide binding site within the enzyme PMID: 19302261
7. SERCA1 levels were not different on immunoblots of the soleus of streptozocin-treated and control rats. PMID: 19738937
8. Inactivation of sarcoplasmic reticulum Ca(2+)-atpase in low-frequency stimulated rat muscle. PMID: 12222829
9. Equivalent levels of SERCA1 inhibition by phospholamban (PLB) and activation by anti-PLB antibody are observed in sarcoplasmic reticulum (SR) from the heart as compared with SercaII isoform from slow-twitch skeletal muscle SR. PMID: 12403631
10. High-intensity, exhaustive exercise causes oxidation of sarcoplasmic reticulum Ca(2+)-ATPase(SERCA). Oxidation of amino acids other than cysteine in SERCA may be responsible, at least in part, for exercise-induced inactivation. PMID: 12684795
11. A serca1 was identified in rat brown adipose tissue that differs in kinetic properties from skeletal muscle SERCA1, and may represent a source of heat production contributing to the thermogenic function of brown adipose tissue. PMID: 12912988
12. upregulation of Ca(2+)transporting-ATPase(Serca1) activity may be an adaptive mechanism and/or a contributory process in the pathology of alcohol-induced muscle disease PMID: 14506614
13. These data confirm that burn trauma alters calcium transporter expression, likely contributing to cardiomyocyte calcium loading and cardiac contractile dysfunction. PMID: 15180978
14. HSP70 can bind to SERCA1a and, depending on the severity of heat stress, protect SERCA1a function by stabilizing the nucleotide binding domain PMID: 15371420
15. Adenoviral Serca1 overexpression triggers an apoptotic response in cultured neonatal but not in adult cardiomyocytes. PMID: 15663193
16. Impaired SERCA activity (with normal protein content) contributes to cardiomyocyte dysfunction in insulin resistant animals, whereas NCX function and expression are normal PMID: 15878173
17. An age-dependent loss of cysteine residues (approx. 2.8 mol of cysteine/mol of SERCA1), which may be partially responsible for the age-dependent decrease in the specific Ca2+-ATPase activity, is reported. PMID: 16307534
18. Muscle glycogen does not influence exercise tolerance and work productivity in working muscles by modulating the structure of protein involved in Ca(2+) sequestering. PMID: 16369770
19. Our studies point to an important regulation of SERCA1b expression at the protein level and hints to a role in the growth of the developing muscle. PMID: 17010426
20. Serca specific antibodies demonstrated a rapid up-regulation of the fast fiber type- specific isoform (Serca1). PMID: 17482761
21. Hearts of SERCA1a(+/+) transgenic mice were markedly protected against I/R injury, suggesting that expression of SERCA 1a isoform reduces postischemic Ca(2+) overload and thus provides potent myocardial protection. PMID: 17630344
22. Serca1 was not altered in diaphragm of buthionine sulfoximine treated rats. PMID: 17717121
23. These results suggest that impairment of the SERCA function may be an early event in excitotoxicity. PMID: 18307036
24. There was no expression of pancreatic SERCA1 mRNA in the control group or the acute pancreatitis group. PMID: 18416460
25. Concluded that increased SERCA activity in adjuvant arthritis was due to increased levels of SERCA protein and structural changes to the protein, probably induced by direct and specific oxidation involving reactive nitrogen species. PMID: 19591012

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KEGG: rno:116601

UniGene: Rn.217139