Recombinant Saccharomyces cerevisiae Mitogen-activated protein kinase HOG1 (HOG1)

1. Hog1p is the first kinase reported to directly regulate Aft1p, impacting on iron homeostasis. PMID: 29032057
2. Hog1 phosphorylates the Spt4 elongation factor at Thr42 and Ser43 and such phosphorylations are essential for the overall transcriptional response upon osmostress. PMID: 29155810
3. Data suggest that Rck2 appears to act as a central hub for many Hog1-mediated secondary phosphorylation events. PMID: 28270554
4. Studied osmotic stress tolerance in Saccharomyces cerevisiae; found OLE1 overexpression improves stress tolerance and activates Hog1 pathway. PMID: 27596631
5. Hog1 plays an important role in connecting calmodulin signaling with the hyperosmotic stress pathway by directly interacting with CaM in Saccharomyces cerevisiae. PMID: 27421986
6. Proteomic and metabolomic comparisons revealed that the xylose-metabolizing mutant strains exhibit altered metabolic pathways relative to the parental strain when grown in xylose. Further analyses revealed that interacting mutations in HOG1 and ISU1 unexpectedly elevated mitochondrial respiratory proteins and enabled rapid aerobic respiration of xylose and other non-fermentable carbon substrates. PMID: 27741250
7. The proteins Slt2 and Hog1 are essential for yeast tolerance to sulphuric acid. PMID: 26845706
8. specific structural elements developed in the course of evolution to suppress spontaneous autophosphorylation of Hog1/p38. The suppressors were kept wobbly, probably to allow activation by induced autophosphorylation, but became stricter in mammalian p38s than in the yeast Hog1. PMID: 26987986
9. Snf1 plays pleiotropic roles in ER stress response by negatively regulating the Hog1 MAPK pathway and the UPR pathway PMID: 26394309
10. Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells. PMID: 26079297
11. Factors involved in mRNA biogenesis and cell-cycle progression regulated by the Hog1 stress-activated protein kinase. (Review) PMID: 25996081
12. Together, our data suggest that Hog1 activity is controlled by intertwined regulatory mechanisms operating with varying kinetics. PMID: 25734609
13. Hog1 mediated a bifurcated cellular response: Activation and commitment to adaptation to osmotic stress are switchlike, whereas protein induction and the resolution of this commitment are graded. PMID: 25587192
14. Hog1 interacts with and phosphorylates components of the core cell cycle transcriptional machinery such as Whi5 and the coregulator Msa1. Phosphorylation of these two transcriptional regulators by Hog1 is essential for inhibition of G1 cyclin expression. PMID: 25733686
15. Results show that Hog1 serves to bypass the general down-regulation of gene expression that occurs in response to physiological stress. PMID: 23158682
16. the general diffusion rate of Hog1 in the cytoplasm as well as its rate of nuclear transport are dramatically reduced following severe volume reduction. PMID: 24278344
17. Data suggest that MAP kinase Hog1 promotes adaptation to hyperosmotic stress partially via regulation of global sumoylation level. PMID: 24498309
18. osmotic up-regulation of only two Hog1-dependent glycerol biosynthesis genes, GPD1 and GPP2, is sufficient for successful osmoadaptation. PMID: 24732094
19. interaction between Ste20 and Sho1 contributed to the activation of Hog1 by Hkr1, but not by Msb2. PMID: 24570489
20. Hog1 activity is required for restart from G1 arrest under osmotic stress conditions, whereas Whi3 acts as a negative regulator for this restart mechanism PMID: 24096659
21. Rck1 inhibits Slt2 MAP kinase pathway activity and then Ptp2, which subsequently activates Hog1. PMID: 24051094
22. Data suggest that kinetics of Hog1 nuclear localization/promoter association are determinants of rapid versus slow transcriptional response of adaptive mechanism to hyperosmotic shock; period of Hog1 nuclear residence affects amplitude of response. PMID: 23758973
23. Proper mRNA biogenesis of stress-responsive genes requires of the coordinate action of synthesis and export machineries by Hog1. PMID: 23645671
24. Hog1 modulates Rtg1/3 complex activity by multiple mechanisms in response to stress. PMID: 22956768
25. Hog1 is activated by glucose and regulates localization of Sac1 lipid phosphatase. PMID: 22882253
26. a single signalling molecule, Hog1, coordinates both replication and transcription upon osmostress PMID: 23178807
27. The findings supported a role for Hog1p in the regulation of mitochondrial function and suggest that constitutive activation of Hog1p is deleterious for isc1-deficient cells under oxidative stress conditions and during chronological aging. PMID: 22445853
28. sphingolipid depletion and hyperosmotic stress have similar effects on the osmosensing machinery of the HOG1 pathway PMID: 22586268
29. Hog1-mediated phosphorylation and degradation of Sic1 at the start of cell division prevented residual activity of the cyclin/CDK complex Clb5/Cdc28 from initiating DNA replication before adaptation to the stress. PMID: 21954289
30. Hog1 interacts with and phosphorylates Ubp3 at serine 695, which is essential to determine the extent of transcriptional activation in response to osmostress PMID: 21743437
31. Results have led to a model in which heme and ergosterol depletion alters membrane fluidity, thereby activating Hog1 for hypoxic induction. PMID: 21467572
32. These results reveal a novel role of the stress-activated protein kinase Hog1p in the control of cell cycle progression as cells leave a resting state. PMID: 21371138
33. Report that two mitogen-activated protein kinases, Slt2 and Hog1, are required for mitophagy in Saccharomyces cerevisiae. PMID: 21576396
34. Hog1, Mot3, and Rox1 repress ERG gene expression during osmotic stress. PMID: 21299653
35. Hog1-mitogen-activated protein kinase pathway is activated by both wild type and mutantPma1. PMID: 21205016
36. p38/Hog1 MAPK is transiently activated in response to osmotic stress; found Hog1 activation increases linearly with stimulus, whereas transcriptional output is bimodal PMID: 21551064
37. cells deficient in Hog1 did not show increased sensitivity to arsenate PMID: 20737431
38. Hog1 MAPK responds to fluctuating osmotic stress in Saccharomyces cerevisiae PMID: 20209100
39. Results describe new aspects of the yeast response to ER stress and identify additional functions of glycerol and the Hog1p MAPK to provide stress resistance. PMID: 20430884
40. Hog1 contributes to the activation of autophagy by enhancing the stability of Atg8, a critical autophagy protein PMID: 20382742
41. The mitogen-activated protein (MAP) kinase Hog1 controls CMV activation by osmotic stress through the ATF/CRE-related transcription factor Sko1 and the yeast osmostress factor Hot1. PMID: 20364387
42. Data show that, at early S phase, Hog1 prevents firing of replication origins by delaying the accumulation of the S phase cyclins Clb5 and Clb6. PMID: 19477922
43. Hog1 is robustly phosphorylated in a Pbs2-dependent way during oxidative stress;data connect activation of the Hog1 MAPK cascade with effectors having a role in oxidative stress resistance PMID: 15341652
44. Thus, our result showed that in HOG pathway, MAPKK has important role in nuclear translocation of Hog1p. PMID: 15707964
45. required for the induction of methylglyoxal-responsive genes and determines methylglyoxal resistance PMID: 15773992
46. the p38 MAPK/Hog1p pathway regulates 3'-UTR-mediated translation by modulating recruitment of Pab1p and Pub1p, which can interact with the translation machinery PMID: 16260593
47. Hog1 plays a role in the stabilization machinery of nitrogen-deprivation-induced autophagy in yeast cells during ambient osmolarity changes. PMID: 16321140
48. exposure to low temperatures triggers a Hog1p-dependent accumulation of glycerol, which is essential for freeze protection PMID: 16371351
49. Results show that survival to osmostress requires regulation of G2 progression through activation of Hog1 and phosphorylation of Hsl1. PMID: 16688223
50. In addition to its various functions during transcriptional initiation, Hog1 behaves as a transcriptional elongation factor that is selective for genes induced upon osmotic stress. PMID: 16857590

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KEGG: sce:YLR113W

STRING: 4932.YLR113W