Recombinant Salmonella typhimurium Outer membrane porin protein OmpD (ompD)

The region for expressing recombinant Salmonella typhimurium ompD contains amino acids 22-362. The theoretical molecular weight of the ompD protein is 53.6 kDa. The ompD protein was expressed in e.coli. The N-terminal 6xHis-SUMO tag was smoothly integrated into the coding gene of ompD, which enables a simple process of detecting and purifying the ompD recombinant protein in the following steps.

The outer membrane porin protein (OmpD) in Salmonella typhimurium is a key component of the bacterial outer membrane, contributing to the selective permeability and integrity of the cell envelope. OmpD functions as a porin, forming channels in the outer membrane that allow the passive diffusion of small hydrophilic molecules, including ions and nutrients, across the bacterial membrane. OmpD plays a crucial role in the uptake of essential nutrients from the external environment, such as sugars and amino acids, facilitating the bacterium's survival and growth. Additionally, OmpD is involved in the response to environmental stresses, including exposure to host immune defenses and antimicrobial agents. The protein contributes to the adaptability of Salmonella typhimurium in diverse host environments and is often implicated in the bacterial pathogenesis process. Understanding the structure and function of OmpD provides insights into the mechanisms of bacterial adaptation and virulence.