Recombinant Tityus zulianus Beta-toxin Tz1

In Stock
Code CSB-EP649921TAAJ
Product Type Recombinant Protein
Size EP: USD786
Uniprot No. Q2NME3
Storage Buffer Tris-based buffer,50% glycerol
Species Tityus zulianus(Venezuelan scorpion)
Purity Greater than 85% as determined by SDS-PAGE.
Research Area Others
Source E.coli
Gene Names N/A
Protein Names Recommended name: Beta-toxin Tz1
Expression Region 21-84aa
Tag Info N-terminal 10xHis-tagged and C-terminal Myc-tagged
Mol. Weight 14.8 kDa
Protein Description Full Length of Mature Protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. Strongly affects skeletal muscle channels Nav1.4/SCN4A, poorly affects the neuronal channels Nav1.6/SCN8A and Nav1.2/SCN2A. Induces spastic paralysis of rear limbs, increased salivation, apnea, tachycardia and increased perspiration.
Subcellular Location Secreted
Protein Families Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Tissue Specificity Expressed by the venom gland.

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