Code | CSB-RA207378A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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IHC | 1:50-1:200 |
DDX58 codes for RIG-I, which preferentially binds to short dsRNA sequences with 5′-phosphates. RIG-I has a very low threshold of activation, and the presence of just 20 suitable dsRNA ligands is sufficient to stimulate RIG-I activation and signaling. RIG-I signaling via MAVS not only leads to the induction of type I IFN responses via TBK1 and IRF7/8, but it also activates caspase-8-dependent apoptosis, preferentially in tumor cells. Furthermore, RIG-I was also found to mediate MAVS-independent inflammasome activation, specifically in the context of viral infection. RIG-I is crucial to the specific innate response to IAV infection.
This recombinant DDX58 antibody was developed with the Single B cell platform. The main process included identification and isolation of single B cells; amplification and cloning of DDX58 antibody gene; expression, screening, and identification of antibody specificity. And this DDX58 antibody has been validated in ELISA, IHC.There are currently no reviews for this product.