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| Code | CSB-RA33255A0GMY |
| Size | US$520 How to order? |
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| Description |
The recombinant N antibody was prepared by obtaining the antibody genes, cloning the genes into a plasma vector to construct vector clone, transfecting the vector clone into a mammalian cell line for transient expression, and purifying the antibody by affinity-chromatography. This recombinant N antibody has been verified to detect the N protein from Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) in the ELISA, GICA. SARS-CoV-2 N protein, a highly immunogenic viral protein, is encoded by the ninth ORF of the virus. It is involved in viral assembly, replication, and host immune response regulation. The N protein recognizes and binds to RNA, allowing for genome encapsidation and participating in the assembly of the virion through its interactions with the membrane protein M. It is an immunodominant antigen in host immune responses that can be used as a diagnostic antigen and immunogen. The N protein is more sensitive than the S protein in response to adaptive immunity, making it a better indicator of early disease. |
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| Uniprot No. | P0DTC9 | ||||||
| Target Names | N (Nucleoprotein) | ||||||
| Alternative Names | N; Nucleoprotein; N; Nucleocapsid protein; NC; Protein N | ||||||
| Species Reactivity | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ||||||
| Immunogen | Recombinant Human Novel Coronavirus Nucleoprotein (N) (1-419aa)(CSB-EP3325GMY) | ||||||
| Immunogen Species | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ||||||
| Conjugate | Non-conjugated | ||||||
| Clonality | Monoclonal | ||||||
| Isotype | Monoclonal mouse (varialbe region)/human (kappa/IgG1 constant)chimeric antibody | ||||||
| Clone No. | 1A6 | ||||||
| Purification Method | Affinity-chromatography | ||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
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| Form | Liquid | ||||||
| Tested Applications | ELISA, GICA | ||||||
| Recommended Dilution |
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| Protocols | ELISA Protocol | ||||||
| Troubleshooting and FAQs | Antibody FAQs | ||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. May modulate transforming growth factor-beta signaling by binding host smad3.
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| Subcellular Location | Virion. Host cytoplasm. |
| Protein Families | Betacoronavirus nucleocapsid protein family |
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