Product Details

Target Name

Novel Coronavirus Nucleoprotein (SARS-CoV-2 N) IgG Antibody

Alternative Names

2019-nCoV; SARS-CoV-2; COVID-19; 2019 Novel Coronavirus; Coronavirus

Abbreviation

SARS-CoV-2 N Ab (IgG)

Uniprot No.

P0DTC9

Species

Homo sapiens (Human)

Sample Types

serum, plasma

Assay Time

1-5h

Sample Volume

50-100ul

Detection Wavelength

450 nm

Research Area

Infectious Diseases

Assay Principle

qualitative

Measurement

Indirect

Precision

Intra-assay Precision (Precision within an assay): CV%<15%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<15%

Three samples of known concentration were tested in twenty assays to assess.

Typical Data

Test parameter	specification	test result
Positive control	≥0.6	0.867
Negative control	≤0.25	0.184
Positive rate	20,Positive	100%
Negative rate	20,Negative	100%

Troubleshooting
and FAQs

ELISA kit FAQs

Storage

Store at 2-8°C. Please refer to protocol.

Lead Time

3-5 working days

Target Data

Function	Nucleoprotein packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. It plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Coronavirus nucleoproteins are phosphoproteins, and are encoded near the 3′ end of the genome. N possesses two RNA-binding domains: an N-terminal domain with adjacent S/R-rich motif and the C-terminal 209 amino acids. N protein is invovled in coronavirus infection with many ways: the C-terminal domain (CTD) of N is important for binding the genomic RNA packaging signal leading to selective genome incorporation, the N3 domain interacts with the endodomain of M to form virions, and the serine–arginine repeat region of N (SR) interacts with the first ubiquitin-like domain of nsp3 in a critical early replication step. Moreover, it has also been demonstrated that N can oligomerize through interactions in the CTD, bind viral RNA through the N-terminal domain, unwind double-stranded nucleic acid in the manner of an RNA chaperone, and pack in a helix through the N-terminal domain, though none of these other functions has yet been demonstrated to be important for infection.
Subcellular Location	Virion i UniRule annotation, Host endoplasmic reticulum-Golgi intermediate compartment i UniRule annotation, Host Golgi apparatus
Protein Families	Betacoronavirus nucleocapsid protein family

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Check Code：

Code	CSB-EL3325HU
Size	96T,5×96T,10×96T
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Human Novel Coronavirus Nucleoprotein (SARS-CoV-2 N) IgG Antibody ELISA Kit

Product Details

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Target Data

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