Your Good Partner in Biology Research
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Your Good Partner in Biology Research
| Code | CSB-EL3325HU |
| Size | 96T,5×96T,10×96T |
| See More Details |  |
| Have Questions? | Leave a Message or Start an on-line Chat |
| Target Name | Novel Coronavirus Nucleoprotein (SARS-CoV-2 N) IgG Antibody | |||||||||||||||
| Alternative Names | 2019-nCoV; SARS-CoV-2; COVID-19; 2019 Novel Coronavirus; Coronavirus | |||||||||||||||
| Abbreviation | SARS-CoV-2 N Ab (IgG) | |||||||||||||||
| Uniprot No. | P0DTC9 | |||||||||||||||
| Species | Homo sapiens (Human) | |||||||||||||||
| Sample Types | serum, plasma | |||||||||||||||
| Assay Time | 1-5h | |||||||||||||||
| Sample Volume | 50-100ul | |||||||||||||||
| Detection Wavelength | 450 nm | |||||||||||||||
| Research Area | Infectious Diseases |
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| Assay Principle | qualitative | |||||||||||||||
| Measurement | Indirect | |||||||||||||||
| Precision |
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| Troubleshooting and FAQs |
ELISA kit FAQs | |||||||||||||||
| Storage | Store at 2-8°C. Please refer to protocol. | |||||||||||||||
| Lead Time | 3-5 working days |
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| Function | Nucleoprotein packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. It plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Coronavirus nucleoproteins are phosphoproteins, and are encoded near the 3′ end of the genome. N possesses two RNA-binding domains: an N-terminal domain with adjacent S/R-rich motif and the C-terminal 209 amino acids. N protein is invovled in coronavirus infection with many ways: the C-terminal domain (CTD) of N is important for binding the genomic RNA packaging signal leading to selective genome incorporation, the N3 domain interacts with the endodomain of M to form virions, and the serine–arginine repeat region of N (SR) interacts with the first ubiquitin-like domain of nsp3 in a critical early replication step. Moreover, it has also been demonstrated that N can oligomerize through interactions in the CTD, bind viral RNA through the N-terminal domain, unwind double-stranded nucleic acid in the manner of an RNA chaperone, and pack in a helix through the N-terminal domain, though none of these other functions has yet been demonstrated to be important for infection. |
| Subcellular Location | Virion i UniRule annotation, Host endoplasmic reticulum-Golgi intermediate compartment i UniRule annotation, Host Golgi apparatus |
| Protein Families | Betacoronavirus nucleocapsid protein family |
