Recombinant Bovine Cystinosin (CTNS)

Code CSB-CF006174BO
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names
CTNS
Uniprot No.
Alternative Names
CTNS; Cystinosin
Species
Bos taurus (Bovine)
Expression Region
1-367
Target Protein Sequence
MIRRWLVIFILFPLQLIEKCESTVDFSVPPIVKLEKGSSTSVSISLPRPLNATLVITFEI TFRSKNVTILQLPDEVVVPPGTTNSSFRVTSQSVGQVTTYLHGNHSNQTSPRIRFLVIHS NIVSIINQVIGWIYFVAWSVSFYPQVITNWRRKSVVGLSFDFVVLNLMGFVAYSVFNIGL FWVPSIKEQFLLKYPNGVNPVDSNDVFFSLHAVALTLVVIVQCLLYERGSQRVSWLAISF LVLSWLFTLIALIMAAVGATTWLQFLFCFSYIKLAVTLVKYFPQAYMNFHYKSTEGWSIG NVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGIFSIIFDVVFFIQHFCLYRKK PGYDQLN
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes. Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity.
Subcellular Location
Lysosome membrane; Multi-pass membrane protein. Melanosome membrane; Multi-pass membrane protein.
Protein Families
Cystinosin family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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