Recombinant Human Coxsackievirus and adenovirus receptor (CXADR)

1. EGF suppresses specifically CAR signaling mainly through transcriptional regulation and drives the xenobiotic response toward a pregnane X receptor (PXR)-mediated mechanism. PMID: 29269410
2. The results pf this study demonstrated that CAR is expressed by mature neurons throughout the brain. In addition, we propose divergent roles for CAR in immature neurons, during neurogenesis, and at the mature synapse. PMID: 27629708
3. data indicate that glycosylation of the extracellular CAR domain has only minor importance for the function of CAR as Coxsackievirus B3 (CVB3) receptor and that the D2 domain is not essential per se but contributes to receptor function by promoting the exposure of the D1 domain on the cell surface PMID: 27030267
4. CAR expression has potential as a marker for monitoring and/or predicting the outcome of gene therapy, and increasing its expression levels may contribute to the upregulation of cellular sensitivity towards adenovirus infection. PMID: 27485384
5. Membrane Dynamics and Signaling of the Coxsackievirus and Adenovirus Receptor. PMID: 26940522
6. Glycan microarray, flow cytometry, surface plasmon resonance and ELISA analyses reveal that the terminal knob domain of the long fiber (52LFK) binds to CAR, and the knob domain of the short fiber (52SFK) binds to sialylated glycoproteins. PMID: 25674795
7. Lovastatin enhances adenovirus-mediated TRAIL induced apoptosis by depleting cholesterol of lipid rafts and affecting CAR and death receptor expression of prostate cancer cells. PMID: 25605010
8. Suggest that distinct forms of CAR play different roles in the undifferentiated state and tight junction formation of human embryos and embryonic stem cells. PMID: 25118298
9. CAR might play a role in adipose tissue dysfunction, given its dual associations with adipogenic and inflammatory genes. PMID: 25459915
10. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively PMID: 25497012
11. This study shows for the first time that lovastatin reduces the expression of CAR and subsequently the replication of CVB3 in human umbilical vein endothelial cells. PMID: 24316867
12. CAR regulates epithelial cell junction stability through control of E-cadherin trafficking. PMID: 24096322
13. Kinetic analyses show that the apparent first-order rate constant for the inactivation of coxsackievirus B3 by soluble CAR (sCAR) at physiological temperatures varies nonlinearly with sCAR concentration. PMID: 24623425
14. CAR substantially impacts the growth and survival of oral squamous cell carcinoma cells as a negative regulator of ROCK in vitro and in vivo. PMID: 23503462
15. novel modifier of ventricular conduction and arrhythmia vulnerability in the setting of myocardial ischemia PMID: 24291282
16. CAR belongs to the increasing list of cell surface molecules that undergo ectodomain shedding and that are substrates for -secretase-mediated RIP. PMID: 24015300
17. The expression of CAR was detected in all normal organs, except in the brain. In malignancies, a high degree of variability was notable, ranging from significantly elevated CAR expression to decreased CAR expression. PMID: 24022195
18. CAR expression in tumor tissues was significantly higher than that in normal lung tissues. CAR expression had a correlation with the histological grade of lung squamous cell carcinoma. PMID: 23307165
19. CAR and ASIC3 co-immunoprecipitate only when co-expressed with PSD-95. PMID: 22809504
20. Combined fiber modifications both to target alpha(v)beta(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5. PMID: 22708837
21. study suggests that CXADR and F2RL1 likely play important roles in BP and obesity variation, respectively; and these findings are consistent with those of other studies, so replication and functional analyses are necessary PMID: 22914544
22. Sp1 is involved in regulation of CAR expression. PMID: 22190856
23. high mRNA expression of Coxsackie-Adenovirus Receptor may support its role in regeneration of the damaged myocardium rather than having any role in viral mediated heart disease PMID: 21641134
24. Results demonstrate that the increase in E-cadherin mobility is constitutively altered by the presence of CAR at FLCARMCF7 cell junctions. PMID: 21850251
25. Adenoviral drifting motions upstream of internalization are mediated by CAR. PMID: 21843868
26. ZEB1 represses CAR expression in both PANC-1 (pancreatic) and MDA-MB-231 (breast) human cancer cells. PMID: 21791114
27. The mechanism of decreased cell migration, a prerequisite for metastasis and invasion, due to increased CAR expression may be explained by reduced alphavbeta3 integrin expression. PMID: 21712047
28. identified a novel splice variant termed CAR4/6 that lacked exon 5 but retained exon 6 encoding the transmembrane domain; CAR4/6 was not expressed in normal cervical tissue but in 42% of CIN2/3 and in most cervical carcinomas PMID: 21431326
29. The authors found that DAF expression allowed attachment of both haemagglutinating and non-haemagglutinating echovirus 6 strains but was not sufficient for promoting echovirus 6 cell entry. PMID: 21420451
30. CAR is a novel estrogen-responsive gene, which is involved in the E(2)-dependent proliferation of breast cancer cells. PMID: 21389059
31. CAR facilitates complex effects during colon carcinogenesis: high CAR potentially prevents apoptosis in adenomas, loss of CAR at the plasma membrane promotes growth, dissemination of primary cancers; high membranous CAR may support distant metastases. PMID: 21468049
32. Need for an efficient post-attachment internalisation signal for optimal Adenovirus 5 uptake and transport following surface binding mediated through FX. PMID: 20949078
33. Transduction of brain dopamine neurons by adenoviral vectors is modulated by CAR expression. PMID: 20862245
34. apical localization of CAR(Ex8) may be responsible for initiation of respiratory adenoviral infections and this localization appears to be regulated by interactions with PDZ-domain containing proteins PMID: 20361046
35. The expression of CAR mRNA and protein in cancer tissue samples are significantly higher than that in the normal and paraneoplastic samples. PMID: 19615283
36. The induction of expression of CAR by endothelial cells in dilated cardiomyopathy suggests that viruses targeting these receptors could more easily gain entry to heart cells after intravascular administration. PMID: 19957088
37. Results suggested that loss of coxsackie and adenovirus receptor in human cancer cell lines under hypoxic conditions occurs in an HIF-1alpha-dependent manner. PMID: 19590529
38. Review: Receptor for the group B coxsackieviruses and adenoviruses, CAR PMID: 11479928
39. adenovirus serotype 30 fiber does not mediate transduction via the coxsackie-adenovirus receptor PMID: 11752156
40. palmitylation is important for stable plasma membrane expression and biological activity of CAR but is not critical for adenovirus receptor performance. PMID: 12021372
41. Since DAF is abundantly expressed in epithelial and endothelial cells, interaction of cardiotropic Coxsackie Virus B with the DAF coreceptor protein, in addition to CAR, could therefore be advantageous to the virus by enhancing viral entry into the heart. PMID: 12920584
42. identified 3 CAR isoforms lacking the transmembrane domain and are the result of alternative RNA splicing events between exons IV and VII (CAR4/7), exons III and VII (CAR3/7), and exons II and VII (CAR2/7); CAR4/7 but not CAR2/7 binds to coxsackievirus B3 PMID: 14978041
43. expression levels of CAR mRNA varies markedly between different tumor types PMID: 15173092
44. CAR interacts with several distinct PDZ-domain-containing proteins and may exert its biological function through these interactions PMID: 15304526
45. Results indicate that the coxsackievirus and adenovirus receptor interacts with multi-PDZ domain protein 1 (MUPP1) and is involved in MUPP1 recruitment to the tight junction. PMID: 15364909
46. Data suggest that modulating the expression of integrin subunits beta3/5 in human neurons may enhance adenoviral infectivity via the coxsackie-adenovirus receptor. PMID: 15456946
47. interacts with a DAF binding Coxsackievirus B3 to induce A-particle formation PMID: 15596863
48. the entire extracellular domain of CAR is of vital importance to the biology of this highly conserved and important protein PMID: 15778494
49. swine vesicular disease virus isolates from early and recent outbreaks have been compared for their capacity to utilize the progenitor virus receptors coxsackie-adenovirus receptor and decay-accelerating factor PMID: 15831949
50. Because the CVB3-specific siRNA is effective against other enteroviruses, siRNAs have potential for a universal anti-enterovirus strategy. PMID: 15956603

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HGNC: 2559

OMIM: 602621

KEGG: hsa:1525

STRING: 9606.ENSP00000284878

UniGene: Hs.627078