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| Code | CSB-CF008709HU |
| Product Type | Transmembrane Protein |
| Size | Pls inquiry other sizes |
| Uniprot No. | O75072 |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Species | Homo sapiens (Human) |
| Sequence | MSRINKNVVLALLTLTSSAFLLFQLYYYKHYLSTKNGAGLSKSKGSRIGFDSTQWRAVKKFIMLTSNQNVPVFLIDPLILELINKNFEQVKNTSHGSTSQCKFFCVPRDFTAFALQYHLWKNEEGWFRIAENMGFQCLKIESKDPRLDGIDSLSGTEIPLHYICKLATHAIHLVVFHERSGNYLWHGHLRLKEHIDRKFVPFRKLQFGRYPGAFDRPELQQVTVDGLEVLIPKDPMHFVEEVPHSRFIECRYKEARAFFQQYLDDNTVEAVAFRKSAKELLQLAAKTLNKLGVPFWLSSGTCLGWYRQCNIIPYSKDVDLGIFIQDYKSDIILAFQDAGLPLKHKFGKVEDSLELSFQGKDDVKLDVFFFYEETDHMWNGGTQAKTGKKFKYLFPKFTLCWTEFVDMKVHVPCETLEYIEANYGKTWKIPVKTWDWKRSPPNVQPNGIWPISEWDEVIQLY |
| Source | in vitro E.coli expression system |
| Gene Names | FKTN |
| Protein Names | Recommended name: Fukutin EC= 2.-.-.- Alternative name(s): Fukuyama-type congenital muscular dystrophy protein |
| Expression Region | 1-461 |
| Tag Info | N-terminal 10xHis-tagged |
| Protein Description | full length protein |
| Storage | Store at -20°C, for extended storage, conserve at -20°C or -80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
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| Function | Glycosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development. |
| Involvement in disease | Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A4 (MDDGA4); Muscular dystrophy-dystroglycanopathy congenital without mental retardation B4 (MDDGB4); Muscular dystrophy-dystroglycanopathy limb-girdle C4 (MDDGC4); Cardiomyopathy, dilated 1X (CMD1X) |
| Subcellular Location | Golgi apparatus membrane, Single-pass type II membrane protein |
| Protein Families | LicD transferase family |
| Tissue Specificity | Widely expressed with highest expression in brain, heart, pancreas and skeletal muscle. Expressed at similar levels in control fetal and adult brain, but is much reduced in Fukuyama-type congenital dystrophy (FCMD) brains. Expressed in migrating neurons, |
| Database Links |
HGNC: 3622 OMIM: 253800 KEGG: hsa:2218 STRING: 9606.ENSP00000223528 UniGene: Hs.55777 |
FKTN Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA008709GA01HU | FKTN Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA008709XA01HU | FKTN Antibody | Homo sapiens (Human) | ELISA, WB (ensure identification of antigen) |
| CSB-PA008709LA01HU | FKTN Antibody | Human | ELISA, WB |
| CSB-PA008709LB01HU | FKTN Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008709LC01HU | FKTN Antibody, FITC conjugated | Human | ELISA |
| CSB-PA008709LD01HU | FKTN Antibody, Biotin conjugated | Human | ELISA |
FKTN Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP008709HU1 CSB-EP008709HU1 CSB-BP008709HU1 CSB-MP008709HU1 |
Recombinant Human Fukutin(FKTN),partial | Yeast E.coli Baculovirus Mammalian cell |
Recombinant Human Glycogen phosphorylase, muscle form(PYGM)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Metalloproteinase inhibitor 1(Timp1)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human Protein-lysine 6-oxidase(LOX)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Peroxisome proliferator-activated receptor gamma(Pparg)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Mouse Pyridoxal phosphate phosphatase(Pdxp)
Express system: Yeast
Species: Mus musculus (Mouse)
Recombinant Rat Thyrotropin subunit beta(Tshb)
Express system: Yeast
Species: Rattus norvegicus (Rat)
Recombinant Human Corticosteroid-binding globulin(SERPINA6)
Express system: E.coli
Species: Homo sapiens (Human)
