Recombinant Human Phosphate-regulating neutral endopeptidase(PHEX)

Code CSB-CF017896HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P78562
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence MEAETGSSVETGKKANRGTRIALVVFVGGTLVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW
Source in vitro E.coli expression system
Gene Names PHEX
Protein Names Recommended name: Phosphate-regulating neutral endopeptidase EC= 3.4.24.- Alternative name(s): Metalloendopeptidase homolog PEX Vitamin D-resistant hypophosphatemic rickets protein X-linked hypophosphatemia protein Short name= HYP
Expression Region 1-749
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Probably involved in bone and dentin mineralization and renal phosphate reabsorption.
Involvement in disease Hypophosphatemic rickets, X-linked dominant (XLHR)
Subcellular Location Membrane, Single-pass type II membrane protein
Protein Families Peptidase M13 family
Tissue Specificity Lymphocytes and fetal brain; not in adult brain, placenta, skeletal muscle and pancreas; not in adult and fetal heart, lung, liver and kidney.
Database Links

HGNC: 8918

OMIM: 300550

KEGG: hsa:5251

STRING: 9606.ENSP00000368682

UniGene: Hs.495834

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