Recombinant Human Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4)

1. KCNQ4 gene polymorphisms associated with susceptibility to noise-induced hearing loss. PMID: 29072670
2. mutations in KCNQ4 gene are unlikely to be a major causative factor of ADNSHL in our studied patients from West Bengal, India, pointing to other genes might be responsible for ADNSHL in our studied patients PMID: 28802383
3. The fundamental processes that dictate Kv7.4 activity. PMID: 27981364
4. A novel KCNQ4 mutation, c.887 G > A (p.G296D), was identified in all five affected members in a Chinese family with autosomal dominant non-syndromic deafness 2. This mutation leads to a glycine-to-aspartic acid substitution at position 296 in the pore region of the KCNQ4 channel. PMID: 28340560
5. Tannic acid activates Kv7.4 and Kv7.3/7.5 K(+) channels resulting in vasodilation. PMID: 26969140
6. Gene and protein expression analyses show the predominance of KV7.4 channels over the other KV7 channel subtypes in human detrusor. PMID: 27761601
7. Kv7.4 channels are present and functional in cardiac mitochondria; their activation exerts a significant cardioprotective role PMID: 26718475
8. analysis of mechanistic insights into the critical roles of Ca(2+)/CaM regulation of the Kv7.4 channel under physiological and pathological conditions PMID: 26515070
9. Interaction between G-protein betagamma subunits and Kv7.4 is crucial for channel responses to membrane voltage. PMID: 25941381
10. genotype-phenotype correlation is analogous to that in KCNQ1 which causes autosomal dominant hereditary long QT syndrome 1 with milder phenotype and the autosomal recessive Jervell and Lange-Nielsen syndrome 1 with more severe phenotype PMID: 26036578
11. This study provides evidence that mouse Kv7 channels may contribute differently to regulating the functional properties of cerebral and coronary arteries. PMID: 25476662
12. The study identified a novel KCNQ4 mutation in a five generation Chinese family and a known KCNQ4 mutation in a six generation Chinese family. PMID: 25116015
13. These findings suggest a protective role for Kv7.4 channels in the pulmonary circulation, limiting its reactivity to pressor agents and preventing hypoxia-induced pulmonary hypertension. PMID: 25361569
14. Identified the c.211delC mutation in the KCNQ4 gene and the c.2967C>A (p.H989Q) mutation in the TECTA gene to be associated with high-frequency sensorineural hearing loss in a Japanese family. PMID: 24655070
15. Kv7.4 currents are inhibited in a CB1 pathway repressed by endocannabinoid 2-AG PMID: 24927567
16. In-frame deletion in KCNQ4 P-loop was identified in family members with autosomal dominant sensorineural hearing loss. PMID: 23443030
17. Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels. PMID: 24297175
18. decreased cell surface expression and impaired conductance of the KCNQ4 channel are two mechanisms underlying hearing loss in DFNA2 PMID: 23750663
19. A new typical audiogram configuration characterized by mid-frequency predominant hearing loss caused by the KCNQ4 V230E mutation. PMID: 23717403
20. The present study supports the idea that a non-truncating mutation around the N-terminus of KCNQ4 pore helix may be related to moderate hearing loss. PMID: 23399560
21. KCNQ4 surface expression was restored by HSP90beta in cells mimicking heterozygous conditions of the DFNA2 patients. PMID: 23431407
22. The data of this study identified a dynamic redox sensor within neuronal M-channels, which mediates reciprocal regulation of channel activity by NO and ROS PMID: 23554485
23. Data indicate a missense mutation encoding a Tyr270His located at the N-terminus of the highly conserved of KCNQ4 pore helix sequence. PMID: 22420747
24. no sequence alterations that segregate with autosomal dominant non-syndromic deafness in either GJB3 or KCNQ4 PMID: 21651318
25. This work describes a gene mutation that modulates touch sensitivity in mice and humans and establishes KCNQ4 as a specific molecular marker for rapidly adapting Meissner and a subset of hair follicle afferents. PMID: 22101641
26. Data show that KCNQ4 and KCNE1 isoforms were suppressed in placentas from term preeclamptic women. PMID: 21730298
27. Identified is novel mutation (c.664_681del) in KCNQ4 associated with hearing loss in a Korean family with dominantly inherited deafness. PMID: 20832469
28. mutations in the pore region, namely L274H, W276S, L281S, G285C, and G296S, as well as the C-terminal mutant G321S in the heterologous expression system, yielded non-functional channels because of endoplasmic reticulum retention of the mutant channels PMID: 20966080
29. Autosomal dominant progressive sensorineural hearing loss due to a novel mutation in the KCNQ4 gene. PMID: 21242547
30. evidence of the cellular etiology and mechanisms of SGN degeneration in DFNA2. PMID: 20739290
31. The W276S mutation has occurred three times independently, and most likely represents a hot spot for mutation in the KCNQ4 gene. PMID: 12112653
32. DFNA2 locus was found to be related to hereditary sensorineural hearing loss. PMID: 12484650
33. KCNQ3 interacts with KCNQ4. . A chimaera (KCNQ1-sid(Q3)) carrying the si domain of KCNQ3 within the KCNQ1 backbone interacted with KCNQ4. PMID: 12524525
34. Src associates with KCNQ2-5 subunits but phosphorylates only KCNQ3-5. PMID: 15304482
35. KCNQ4 phosphorylation via PKA and coupling to a complex that may include prestin can lead to the negative activation and the negative resting potential found in adult outer hair cells. PMID: 15660259
36. Polymorphisms within the KCNQ4 gene are associated with susceptibility Noise-induced hearing loss. PMID: 16823764
37. Results shows KCNQ4 SNPs were significantly associated with Age-related hearing impairment. PMID: 16917933
38. a novel mutation of KCNQ4 gene was identified in patients with nonsyndromic deafness. PMID: 17033161
39. In conclusion, this work demonstrates that inactivation is a key regulatory mechanism of Kv7.4 and Kv7.5 channels. PMID: 17237198
40. high-resolution structure of the Kv7.4 A-domain Tail together with biochemical experiments show that the domain is a self-assembling, parallel, four-stranded coiled coil PMID: 17329207
41. G296S mutant exerts a strong dominant-negative effect on potassium currents by reducing the wild type KCNQ4 channel expression at the cell surface PMID: 18030493
42. among the allowed assembly conformations are KCNQ3/4 and KCNQ4/5 heteromers. PMID: 18786918
43. KCNQ4 mutations associated with progressive sensorineural hearing loss. PMID: 18797286
44. Two novel missense mutations and a stop mutation were detected in three American families predicted to have DFNA2-related deafness; The latter is the first DFNA2-causing stop mutation reported in KCNQ4. PMID: 18941426

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HGNC: 6298

OMIM: 600101

KEGG: hsa:9132

STRING: 9606.ENSP00000262916

UniGene: Hs.473058