Recombinant Human UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1(B3GALNT1)

Code CSB-CF002488HU
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names B3GALNT1
Uniprot No. O75752
Alternative Names B3GALNT1; B3GALT3; UNQ531/PRO1074; UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1; Beta-1,3-GalNAc-T1; Beta-1,3-galactosyltransferase 3; Beta-1,3-GalTase 3; Beta3Gal-T3; Beta3GalT3; b3Gal-T3; Beta-3-Gx-T3; Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase; Globoside synthase; UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
Species Homo sapiens (Human)
Expression Region 1-331
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Transfers N-acetylgalactosamine onto globotriaosylceramide. Plays a critical role in preimplantation stage embryonic development.
Gene References into Functions
  1. b1,3GalNAc-T1 uses different acceptors to form immunologically distinct glycosphingolipids. PMID: 26055721
  2. TINAGL1 and B3GALNT1 are possible candidates for drug compounds that inhibit their gene expression PMID: 25521548
  3. The Pk phenotype is resulted from 433 C>T mutation in the B3GALNT1 gene. PMID: 26037356
  4. The N-acetylgalactose aminotransferase gene 539G>C mutation resulted in A2B phenotype generation, and individual serum contained the anti-A1 antibody. PMID: 24782133
  5. The number of GLOB-null alleles was increased by 50%. PMID: 23927681
  6. identification of four inactivating mutations in the UDP-N-acetylgalactosamine: globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase gene involved in globoside-deficient P(k) blood group phenotype PMID: 12023287
  7. Eighteen SNPs in the MC1R gene and P genes were genotyped in 52 individuals by the direct sequencing method, and 4 SNPs (MC1R gene: R163Q and P gene: IVS5 + 1001, IVS13 + 113, and H615R) were selected on the basis of differences in frequencies. PMID: 18839200

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Subcellular Location Golgi apparatus membrane; Single-pass type II membrane protein.
Protein Families Glycosyltransferase 31 family
Tissue Specificity Higher expression in heart and brain, and to a lesser extent in lung, placenta, kidney and testis. Lower expression in liver, spleen and stomach. No expression in skeletal muscle.
Database Links

HGNC: 918

OMIM: 111400

KEGG: hsa:8706

STRING: 9606.ENSP00000323479

UniGene: Hs.418062

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