Recombinant Mouse Free fatty acid receptor 1 (Ffar1)

1. FFAR1 point mutation R258W abrogates fatty acid-induced insulin secretion PMID: 29031729
2. We found that FFAR1-/- female mice showed significant impairments in maternal behavior, and exhibited an emotionally altered behavior, when compared to WT mice. Our findings suggest that the dysfunction of brain PUFA-GPR40/FFAR1 signaling might induce damage to emotional and maternal behavior in female mice. PMID: 28769007
3. GPR40 and (GPR120) act in concert in the hypothalamus to reduce energy efficiency and regulate the inflammation associated with obesity. PMID: 28446241
4. GPR40 role in the bone loss PMID: 27611773
5. These findings suggested that dysfunction of the GPR40/FFAR1 signaling pathway altered the endogenous pain control system and that this dysfunction might be associated with the development of chronic pain. PMID: 28723961
6. Together, our data indicate effects of AgoPAMs that go beyond glucose lowering previously observed with GPR40 partial agonist treatment with additional potential for weight loss. PMID: 28292762
7. These results support the hypothesis that mercaptoacetate stimulates food intake by blocking fatty acid effects on GPR40. PMID: 26984894
8. These results indicated that GPR120 enhanced and GPR40 inhibited the cell motile activity of highly migratory osteosarcoma cells. PMID: 28159555
9. Results suggest that brain GPR40/FFAR1 is associated with anxiety- and depression-related behavior regulated by the increment of noradrenaline in the brain. PMID: 27979701
10. Data revealed a weak influence of GPR40 agonist on osteoblast markers expression. Nevertheless, a significant increase in OPG expression was observed upon GW9508 treatment that contribute to explain the GPR40-related osteoporosis prevention PMID: 26699911
11. In the retinas of Vldlr(-/-) mice with low fatty acid uptake but high circulating lipid levels, we found that Ffar1 suppresses expression of the glucose transporter Glut1 PMID: 26974308
12. activation of the hypothalamic GPR40/FFA1 signaling pathway may regulate beta-endorphin release via PC2, and regulate the endogenous pain control system PMID: 26071852
13. These results suggest that both PPARgamma and GRP40 are required for RSG-induced inhibition of mouse calvaria osteoblast differentiation, which is mediated through GSK3beta-dependent pathway. PMID: 26116229
14. GPR40 signaling pathway plays an important suppressive role in spinal nociceptive processing after inflammation or nerve injury PMID: 25889021
15. GPR40/FFAR1 indirectly modulates organ-specific effects of CLAs. PMID: 25895678
16. knocking down the expression of the regulatory subunit PKAR1alpha, thereby reproducing the effects of IL-1beta and PGE on VSMCs, we demonstrated the contribution of PKA activity to the observed behavior of VSMCs PMID: 26408932
17. results demonstrate that GPR40 deficiency leads to an extended osteoarthritis phenotype PMID: 25585625
18. No effects of BCAO were noted on hypothalamic GPR40 protein expression. PMID: 25281202
19. Intense GPR40 mRNA expression was shown by in situ hybridization in mouse hippocampal and motor cortex neurons. A selective agonist produced the phosphorylation of CREB and of ERK1/2. PMID: 24550142
20. Brain GPR40 signaling may regulate depression-related behavior. PMID: 24758921
21. Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses inflammatory chronic pain. PMID: 24349089
22. results suggest that palmitic acid induces superoxide production and potentiates glucose-stimulated insulin secretion through NADPH oxidase and GPR40 pathways in pancreatic cells. PMID: 23817296
23. Potent free fatty acid 1 receptor agonist TUG-469 may be promising candidate for the treatment of type 2 diabetes mellitus. PMID: 23861168
24. Silencing FFAR1 expression reduced the PIO-mediated increases in the expression of above proteins. PMID: 24360748
25. Our findings indicate that loss of GPR40/FFAR1 function does not play an important role in inducing or exacerbating diabetes. PMID: 23331570
26. Allosterism at FFA1 can contribute to postprandial glucose management by stimulating insulin secretion via an extrapancreatic mechanism of action. PMID: 23403053
27. In vitro, in GPR40-expressing human embryonic kidney (HEK)-293 cells, [(14)C]-14E-AA (radiolabeled TAA) bound specifically, and TAA induced calcium transients, extracellular signal-regulated kinase 1/2 phosphorylation PMID: 23520164
28. The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation PMID: 23335512
29. G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1. PMID: 22820510
30. Data indicate that thiazolidinediones (TZDs) rapidly activated Erk1/2 and p38 through G protein-coupled receptor 40 (GPR40), a receptor expressed on the surface of osteocytes. PMID: 22593579
31. Antinociception via beta-endorphin release is mediated through GPR40 signaling in the supraspinal area and provides valuable information on a novel therapeutic approach for pain control. PMID: 22137657
32. Long-chain fatty acid receptor GPR40 induces secretion of cholecystokinin by duodenal I cells in response to dietary fat. PMID: 20955703
33. These results indicate that GPR40 mediates the short-term effects of free fatty acids on glucose-stimulated insulin secretion, but does not mediate the chronic lipotoxicity on beta-cells. PMID: 21036144
34. GPR40 is integral to the antidiabetic effects of Adrb3 agonists. PMID: 20416356
35. GPR40 is expressed in the taste buds, mainly in type i cells. GPR40 knockout mice show a diminished preference for linoleic acid and oleic acid. PMID: 20573884
36. The results demonstrate that GPR40 is indeed necessary, at least in part, for fatty-acid-stimulated insulin release. PMID: 16044321
37. GPR40 plays an important role in the chain of events linking obesity and type 2 diabetes. PMID: 16054069
38. GPR40 has the capacity to respond to fatty acids with chain lengths of four or greater. PMID: 16267104
39. This study demonstrates that GPR40 is present and active in pancreatic alpha-cells and puts further emphasis on the importance of this nutrient sensing receptor in islet function. PMID: 17214971
40. GPR40 contributes approximately half of the full acute insulin secretory response to fatty acids in mice but does not play a role in the mechanisms by which fatty acids chronically impair insulin secretion. PMID: 17395749
41. cell-specific expression of the GPR40 gene involves a characteristic chromatin organization of the locus and is controlled at the transcriptional level through HR2, a potent beta cell-specific enhancer PMID: 17525159
42. Might be implicated in the control of pancreatic beta-cell mass plasticity; may provide a link between obesity and type 2 diabetes. PMID: 17556534
43. Gpr40 modulates FFA-stimulated insulin secretion from beta-cells not only directly but also indirectly via regulation of incretin secretion PMID: 18519800
44. GPR40 plays a role not only in fatty acid modulation of insulin secretion, but also in glucose induced insulin secretion after high-fat feeding PMID: 18559658
45. FFAR1 is required for normal insulin secretion in response to fatty acids; however, Ffar1(-/-) mice are not protected from high-fat diet-induced insulin resistance or hepatic steatosis. PMID: 18678612
46. Deletion of GPR40 impairs insulin secretion in vivo in response to fatty acids and also to glucose and arginine, without altering intracellular fuel metabolism in islets. PMID: 19720802

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KEGG: mmu:233081

STRING: 10090.ENSMUSP00000055564

UniGene: Mm.425422