Recombinant Mouse Ghrelin O-acyltransferase (Mboat4)

1. the effect of GOAT on gastric acid secretion and expression of ghrelin in vitro, were investigated. PMID: 29966658
2. GOAT immunoreactivity is aggregated at the base of the dentate granule cell layer in wild-type mice. This was not affected by the pharmacological inhibition of GHSR1a or the metabolic state-dependent fluctuation of systemic ghrelin levels. But it was absent in the GHSR1a knockout mouse hippocampus, implying that the expression of GHSR1a may be a prerequisite for the production of GOAT. PMID: 29063591
3. Both ghrelin and GOAT are localized primarily in the red pulp of the spleen. Importantly, in the thymus, ghrelin was predominantly localized to the medulla, whereas GOAT was found in the cortex, implying differing roles in T cell development. Both regulates obesity-induced inflammation. PMID: 28368434
4. anxiogenic actions of GOAT deletion not related to high plasma des-acyl ghrelin PMID: 27490185
5. GOAT knock-out pregnant mice on calorie-restricted diet are more prone to hypoglycemia than wild type. PMID: 27701682
6. circadian rhythmicity of ghrelin signaling requires Bmal1 and is driven by a food-responsive clock in the gastric ghrelin-secreting cell that not only regulates ghrelin, but also GOAT activity. PMID: 26576661
7. observations demonstrate that germline loss of ghrelin-O-acyltransferase alters Growth Hormone release and patterning PMID: 26442444
8. Altered lipid and salt taste responsivity in ghrelin and GOAT null mice. PMID: 24124572
9. The absence of GOAT does not alter glucose intolerance suggesting that desacyl/acyl ghrelin is not a major denominator for glucose homeostasis. PMID: 23630616
10. The absence of the enzyme GOAT does not play a significant role in maintenance of body core temperature or metabolic adaptation during exposure to low external temperatures. PMID: 22526011
11. GOAT induced ghrelin acylation regulates hedonic feeding. PMID: 22982020
12. The endogenous GOAT-ghrelin-growth hormone secretagogue receptor system is not essential for the maintenance of euglycemia during prolonged calorie restriction. PMID: 22363801
13. While there is considerable overlap in expression pattern between ghrelin and ghrelin O-acyltransferase (GOAT), the latter exhibits some unique tissue expression that could suggest that additional peptides may be acylated and await discovery.(Review) PMID: 21600256
14. This is the first report that the GOAT/ghrelin system regulates bile acid metabolism, and these findings suggest a novel function of GOAT in the regulation of intestinal bile acid reabsorption.. PMID: 21965605
15. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice PMID: 20231469
16. The present study demonstrates that stomach GOAT mRNA levels correlate with circulating acylated-ghrelin levels in fasted and diet-induced obese mice. PMID: 20035826
17. These data suggest species differences between rats and mice in gastric GOAT expression perhaps resulting in a different role of the MBOAT4 enzyme in the rat stomach. PMID: 20059966
18. The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin. PMID: 19628676
19. Study identifies GOAT (Ghrelin O-Acyltransferase), a polytopic membrane-bound enzyme that attaches octanoate to serine-3 of ghrelin; consistent with its function, GOAT mRNA is restricted to stomach and intestine, the ghrelin-secreting tissues. PMID: 18267071
20. The identification and characterization of human GOAT, the ghrelin O-acyl transferase, is reported. PMID: 18443287
21. GOAT is the only member of the MBOAT family whose expression is highly enriched within gastric ghrelin cells and whose whole body distribution mirrors that of ghrelin. PMID: 19401456
22. GOAT mRNA was expressed in murine cartilage explants as well as in the cultured murine chondrogenic ATDC-5 cell line. PMID: 19479831
23. a four-amino acid peptide derived from the N-terminal sequence of ghrelin can be modified by GOAT, indicating that these four amino acids constitute the core motif for substrate recognition by the enzyme. PMID: 19501572
24. ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted. PMID: 19503064

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KEGG: mmu:234155

STRING: 10090.ENSMUSP00000092988

UniGene: Mm.324008