Recombinant Mouse Kappa-type opioid receptor (Oprk1)

1. Our results indicate that the stimulation of kappa-opioid receptors in the hippocampus may ameliorate cognitive dysfunction through the activation of the cholinergic system. These findings may offer a therapeutic alternative approach in the treatment of depression patients' symptoms PMID: 29863085
2. Suggest that peripheral and central MOR and central KOR may be involved in the modulation of scratching behaviour in imiquimod-treated mice. PMID: 28512665
3. chronic KOR activation increased phosphorylation of NR2B subunit of NMDA at tyrosine 1472 (pNR2B NMDA) in the hippocampus, but not in the cortex. PMID: 27634008
4. Pre- and postsynaptic colocalization of kappa opioid receptor and D2R supports a role for kappa opioid receptor potentiating both the D2R inhibitory autoreceptor function and the inhibitory action of D2R on efferent medium spiny neurons. Kappa opioid receptor co-activation accelerates D2R sensitization by contributing to decrease dopamine release in the nucleus accumbens. PMID: 28531297
5. Mechanical allodynia produced by monosodium iodoacetate (MIA) was enhanced in mice lacking KOR or PDYN gene. In contrast with the nociceptive manifestations induced by osteoarthritis, the increased microglial expression on the lumbar section of the spinal cord after MIA administration was similar in KOR-KO, PDYN-KO and WT littermates. Moreover, anhedonic- and anxiolytic-like states were revealed after MIA administration. PMID: 27567942
6. The kappa opioid receptor was identified as a key player mediating the effects of buprenorphine in tests sensitive to antidepressant drugs in mice. PMID: 26979295
7. This study provides the first evidence for a time- and learning-dependent property of neocortical kappa opioid receptor in facilitating acquisition and consolidation of associative memories. PMID: 28119127
8. triazole 1.1 retained the antinociceptive and antipruritic efficacies of a conventional KOR agonist, yet it did not induce sedation or reductions in dopamine release in mice, nor did it produce dysphoria as determined by intracranial self-stimulation PMID: 27899527
9. This study reports a cluster of compounds that are highly effective in enhancing remyelination and identifies kappa-opioid receptor (KOR) as a positive regulator for oligodendroglial differentiation, implicating KOR agonism as a potential strategy to accelerate remyelination. PMID: 27466337
10. GRK2 upregulation causes kappa-opioid receptor desensitization in diabetic heart PMID: 27865836
11. Study showed that Dyn-A, the endogenous kappa opioid receptor agonist, significantly hyperpolarized and inhibited neurons in the paraventricular nucleus of mouse thalamus PMID: 26056031
12. Suggest that mixed cardiac ion channel blockade my mediated the antiarrhythmia actions of kappa-opioid receptor antagonist PD117,302. PMID: 26086860
13. Findings suggest that activation of kappa opioid receptor (kappa-opioid receptor) reduces hyperglycemia in streptozotocin-induced diabetic mice. PMID: 25186835
14. kappa-Opioid receptor mediates the antinociceptive effect of nitrous oxide in mice. PMID: 25086587
15. The data of this study provide evidence that KORs on VTA DA neurons are necessary to mediate KOR-mediated aversive behavior. PMID: 23921954
16. Ablation of kappa-opioid receptors from brain dopamine neurons had anxiolytic-like effects. PMID: 23446450
17. Natural food reward and systemic ghrelin activate Kappa opioid receptors in the ventral tegmental area. PMID: 23220294
18. Data suggest that activation of neurokinin 3 and kappa-opioid receptors (NK3R and KOR) excites and inhibits kisspeptin, neurokinin B (NKB), and dynorphin (KNDy neurons). PMID: 23744642
19. Data (including data from KOR knockout mice) suggest that KOR modulates GABAergic synaptic responses in the central amygdala and modulates the effects of ethanol as one of multiple opioid system-dependent actions of ethanol in the central amygdala. PMID: 23587526
20. hKOR activates p38 MAPK through a phosphorylation and arrestin-dependent mechanism; however, activation differs between hKOR and rKOR for some ligands PMID: 23086943
21. these data suggest that endogenous prodynorphin-derived peptides sufficiently activate KOP receptors during acute seizures, and importantly in situations of reduced dynorphinergic signaling-like in epilepsy-the exogenous activation of KOP receptors might also have strong neuroprotective effects during excitotoxic events. PMID: 21391243
22. Centrally administered apelin-13 elicited depression-like behavior in mice, which was mediated via APJ receptor and kappa-opioid receptor, but not CRF receptor. PMID: 22728209
23. Repeated stress exposure reduces KOR inhibitory regulation on 5-serotonin (HT)neuronal excitability postsynaptically. PMID: 22956823
24. results demonstrate that KOR provides important inhibitory control over presynaptic GABAergic signaling within the bed nucleus of the stria terminalis PMID: 22225848
25. Macrophages express kappa opioid receptors, which signal via ERK1/2 phosphorylation and which are upregulated by proinflammatory IFN-gamma. PMID: 22424981
26. The Ro1 model represents a model of communicating hydrocephalus. PMID: 22291910
27. During stress exposure, kappa-opioid receptor activation is necessary and kappa-receptor activation in the amygdala alone is sufficient to increase nicotine-seeking behavior measured by conditioned place preference. PMID: 22279233
28. Data indicate that the potency and selectivity of the in vitro kappa antagonism were confirmed in the tail-flick analgesia model. PMID: 21744827
29. The opioid system is a new regulator of vascular development that simultaneously modifies 2 distinct vascular properties, embryonic cell differentiation and vascular pathfinding. PMID: 21460241
30. we suggest NKB & dynorphin act autosynaptically on kisspeptin neurons in the arcuate nucleus to synchronize & shape pulsatile secretion of kisspeptin & drive the release of gonadotropin-releasing hormone from fibers in the median eminence [neurokinin B] PMID: 19776272
31. Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling PMID: 20534436
32. These results show that kappa opioid receptor system has different effects after pIONL in CNS and PNS: KOR activation promotes CNS astrocytosis and microglial or stem cell proliferation but inhibits macrophage proliferation in PNS. PMID: 20109235
33. Kappa opioid receptor contributes to EGF-stimulated neurite extension in development. PMID: 20133770
34. Corticotropin Releasing Factor and dynorphin/KOR systems may coordinate stress-induced anxiety behaviors and aversive behaviors via different mechanisms. PMID: 20052275
35. Kappa opioid receptor binds to Sp1 and inhibits the ERK pathway PMID: 12171913
36. A negative regulatory pathway for KOR transcription involves a putative enhancer region in its 3'-UTR. KOR mRNAs using the second poly(A) is more stable than that using the first poly(A). PMID: 12237335
37. KOR-/- animals produced significant higher levels of antigen-specific total Ig, IgM, IgG1 and IgG2a antibodies. Endogenous activation of kappa-opioid receptors may exert a tonic inhibition of antibody response. PMID: 12507774
38. The difference in alcohol preference between B6 and BALB/cJ strains is not correlated with polymorphisms of Oprk1; DBA/2J mice (alcohol-avoiding) show expression of Oprk1 mRNA subtypes (alternatively spliced) that are different from B6 and BALB/cJ. PMID: 12657375
39. No impairment in spatial learning in kappa opioid receptor mutants or in mossy fibers in CA3 hippocampal region long-term potentiation. PMID: 12884965
40. The 5'- and 3'-untranslated regions of KOR, either alone or in combination, are able to mediate transport of mRNAs to processes of P19 embryonal carcinoma neurons and axons of dorsal root ganglia. PMID: 12920195
41. Collectively, the high potency and efficacy and the relative abundance suggest that Big Dynorphin may play a role in the kappa opioid receptor-mediated activation of G proteins. PMID: 16515546
42. The present study demonstrated that morphine can produce thermal antinociception via the kappa opioid receptor in the spinal cord in the absence of the mu opioid receptor. PMID: 16530171
43. opioid modulation of extracellular signal-regulated kinase activity may play an important role in embryonic stem cell fate decisions by directing the cells to specific lineages PMID: 16954126
44. These findings suggest that, although kappa opioid receptors can hyperpolarize dopamine neurons, they also suppress dopamine release by direct actions at the release site. PMID: 17122312
45. provided evidence for mRNA transport and regulation of presynaptic protein synthesis of nonstructural proteins like KOR in primary sensory neurons PMID: 17167054
46. MOR and KOR are important in skin homeostasis, epidermal nerve fiber regulation, and pathophysiology of itching PMID: 17185983
47. Results support the hypothesis that KOR activation induces spinal astrocyte proliferation, which may contribute to cellular reorganization after sciatic nerve damage. PMID: 17344394
48. Changes in kappa opioidergic receptor expression in brain regions may be involved in the long-term consequences of stroke and could be used as biomarker of neuronal alteration through the use of imaging techniques in the clinic. PMID: 17676326
49. Co-treatment with ultra-low-dose naltrexone or nor-binaltorphimine may selectively block signaling by endogenous GM1-sensitized excitatory kappa opioid receptors, unmasking inhibitory kappa opioid receptor signaling. PMID: 17692296
50. provides evidence for a microtubule-dependent, active axonal kappa opioid receptor mRNA-transport process that involves Copb1 and can stimulate localized translation PMID: 17698811

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KEGG: mmu:18387

STRING: 10090.ENSMUSP00000027038

UniGene: Mm.7977