Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity).
Involvement in disease
Defects in Rxfp2 seems to be a cause of impaired testicular descent (known as cryptorchidism).
Cell membrane, Multi-pass membrane protein
G-protein coupled receptor 1 family
Expressed in embryonic and adult gonads of males and females, as well in male gubernarculum. Expressed also in brain. Not detected in kidney, spleen and heart.