Recombinant Mouse Small conductance calcium-activated potassium channel protein 2 (Kcnn2)

1. SK2 channels regulate mitochondrial respiration and mitochondrial Ca(2+) uptake. PMID: 28282037
2. Probing the responsible cellular mechanisms pinpoints a disturbance in the expression and function of small-conductance Ca(2+)-activated K(+) (SK) channels and reveals an important role for both SK2 and SK3 channels in normal regulation of serotinin (5-HT) neuronal excitability. PMID: 27874831
3. SK2 is nuclear in primary neurons and, unexpectedly, overexpressed SK2 is neurotoxic in a dose-dependent manner.. We also found that SK2 is hyperphosphorylated in the brain samples from a model of HD, the BACHD mice.Our results identify a novel regulator of mutant huntingtin-mediated neurotoxicity and provide a new target for developing developing therapies for Huntington disease PMID: 28175299
4. Thus, MPP2 is a novel synaptic scaffold that is required for proper synaptic localization and function of SK2-containing channels. PMID: 26880549
5. In addition to a well-established role for KCa2.x channels in migration, blockade of these channels was potently cytotoxic in breast cancer cell lines. PMID: 26454020
6. Atrial SK2 and SK3 are significantly down-regulated from accelerated turnover in diabetic mice, resulting in action potential prolongation and arrhythmias. PMID: 25605734
7. enhanced SK2 channel control over NMDAR contributes to LTP impairment via increased PP2A activity following context dependent sensitization to morphine. PMID: 23735878
8. This study reveleated that outer hair cells of SK2 knockout mice had few small efferent terminals. Synaptic cisterns were present, but smaller than those of wild-type littermates. PMID: 24122766
9. SK2 and SK3 channels are expressed in different populations of motoneurons in rats and mice but not in cats PMID: 23129791
10. Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction. PMID: 23430260
11. Virtually all Cav2.1 clusters are colocalized in Purkinje cells with two types of calcium-activated potassium channels, SK2 and BK. PMID: 23426693
12. A developmental increase and gradient in SK2-containing channel surface expression is found that underlie the influence on neurotransmission. PMID: 22072564
13. Sleep spindle occurrence is shaped by SK2-channel-mediated repetitive reticular thalamic nucleus neuron bursting & contributes to augmented NREMS consolidation & arousal threshold. PMID: 23035101
14. Long-lasting plasticity of intrinsic excitability in dendrites results from changes in the gain of the SK2 channel regulatory mechanism of neurons. PMID: 22794265
15. increasing SK2 channel activity, or preventing ischemia-induced loss of synaptic SK2 channels, are promising and novel approaches to neuroprotection following cerebral ischemia PMID: 21712833
16. Results indicate that SK2-L directs synaptic SK2-containing channel expression and is important for normal synaptic signaling, plasticity and learning. PMID: 21602822
17. Thus, SK2-sh as a downstream target of cytokines, provide a promising target for additional investigation regarding potential therapeutic intervention.(SH2-SH PROTEIN, MOUSE) PMID: 18624921
18. Under basal conditions SK2 channels do not undergo rapid recycling and are present within the spine in a population of endosomes distinct from alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPARs). PMID: 20810893
19. Because of the marked differential expression of SK2 channels in the heart, specific ligands for Ca2+-activated K+ currents may offer a unique therapeutic opportunity to modify atrial cells without interfering with ventricular myocytes PMID: 13679367
20. Here we report the cloning, characterization, and expression of a complete SK2 cDNA from the mouse cochlea. The cDNAs of the mouse cochlea alpha9 and alpha10 acetylcholine receptors were also obtained, sequenced, and coexpressed with the SK2 channels. PMID: 14657188
21. At the cellular level, SK2-like immunoreactivity is primarily localized to somatic and dendritic structures in mouse brain. PMID: 15234350
22. the SK2 gene encodes two subunit proteins; native SK2-L subunits may preferentially partition into heteromeric channel complexes with other SK subunits PMID: 15797870
23. SK2 channels regulate hippocampal synaptic plasticity and play a critical role in modulating mechanisms of learning and memory. PMID: 16467533
24. SK2 overexpressers were not protected from acoustic injury PMID: 17267753
25. These findings suggest a possible transcriptional cross talk between glucocorticoid receptors and NF-kappaB in the intronic promoter regulation of SK2-S channel gene transcription. PMID: 17396235
26. SK2 channels have a functional influence on inner hair cells (IHC) during immature development. The altered Ca(2+) dependence of exocytosis in adult IHCs is likely to be a consequence of their disrupted action potential activity at immature stages. PMID: 17627990
27. Overexpression of SK2 channels results in the shortening of the spontaneous action potentials of the atrioventricular node cells and an increase in the firing frequency PMID: 18096820
28. SK2 gene is expressed in the bladder and that it is essential for the ability of SK channels to regulate urinary bladder smooth muscle contractility PMID: 18353877
29. Transgenic mice overexpressing SK2 channels (SK2+/T mice) exhibit marked deficits in hippocampal memory and synaptic plasticity. PMID: 18385475
30. describe a deletion in the 5' region of the Kcnn2 gene encoding the SK2 subunit in the neurological frissonnant (fri) mutant. The frissonnant mutant phenotype is characterized by constant rapid tremor and locomotor instability. PMID: 18604572
31. SK2 channels are required both for expression of functional nAChRs, and for establishment and/or maintenance of efferent terminals in the cochlea. PMID: 18818242
32. Results suggest a hierarchy of activity necessary to maintain early olivocochlear synapses at their targets, with SK2 serving an epistatic, upstream, role to the nicotinic acetylcholine receptors. PMID: 18848895
33. The functional roles of SK2 channels in whole animals are discussed, and a possible link is provided between abnormalities in cardiac SK2 channels and cardiac arrhythmias. PMID: 19139040
34. demonstrate that proper membrane localization of a small-conductance Ca(2+)-activated K(+) channel (SK2 or K(Ca)2.2) is dependent on its interacting protein, alpha-actinin2, a major F-actin crosslinking protein. PMID: 19815520
35. SK2 null mice exhibit loss of nAChR-induced activity in mouse outer hair cells and efferent nerve fiber and synaptic boutons degeneration in the cochlea. SK2 is epistatic to the nAChR alpha10 gene as assessed in the SK2/alpha10 double null mouse. PMID: 18848895

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KEGG: mmu:140492

STRING: 10090.ENSMUSP00000067884

UniGene: Mm.411614