Recombinant Mouse Somatostatin receptor type 4 (Sstr4)

Code CSB-CF022727MO
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Source in vitro E.coli expression system
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Product Details

Target Names
Sstr4
Uniprot No.
Alternative Names
Sstr4; Smstr4; Somatostatin receptor type 4; SS-4-R; SS4-R; SS4R
Species
Mus musculus (Mouse)
Expression Region
1-384
Target Protein Sequence
MNAPATLLRGVEDTTWTPGINASWAPEQEEDAMGSDGTGTAGMVTIQCIYALVCLVGLVG NALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVRSAAALRHWPFGAVLCRAVLS VDGLNMFTSVFCLTVLSVDRYVAVVHPLRTATYRRPSVAKLINLGVWLASLLVTLPIAVF ADTRPARGGEAVACNLHWPHPAWSAVFVIYTFLLGFLPPVLAIGLCYLLIVGKMRAVALR GGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANS CANPILYGFLSDNFRRSFQRVLCLRCCLLETTGGAEEEPLDYYATALKSRGGAGCICPPL PCQQEPVQAEPGCKQVPFTKTTTF
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.
Gene References into Functions
  1. Study provides first evidence that somatostatin 4 receptor activation is involved in the behavioral and neuroendocrine alterations induced by chronic stress with a crucial role of plastic changes in the amygdala. PMID: 28161436
  2. The results of this study revealed that sst4 mediates anxiolytic and antidepressant-like effects by enhancing the stress-responsiveness of several brain regions with special emphasis on the amygdala. PMID: 26387439
  3. SSTR4 and delta-Opioid receptor (dOR) exist in a heteromeric complex and function in synergistic manner. PMID: 24416361
  4. SSTR4-like immunoreactivity increases in ApoD(-/) mice in all major nuclei of hypothalamus, median eminence, and ependymal cells of third ventricle. PMID: 22581439
  5. SSTR4 ablation has an effect on inflammatory peptide and receptor expression in the non-inflamed and inflamed murine intestine PMID: 19426160
  6. The effect of sst2 receptor knockout on sst4 receptor mRNA localization and binding sites throughout the brain has been determined. PMID: 11897118
  7. Somatostatin sst(4) receptor-selective agonists could be potential candidates for the development of a completely novel group of anti-inflammatory drugs for the treatment of airway inflammation and hyperresponsiveness. PMID: 17961545
  8. Somatostatin receptor subtype 4 couples to the M-current to regulate seizures. PMID: 18385315
  9. during the inflammatory conditions the released somatostatin has pronounced counterregulatory effects through sst(4) receptor activation. PMID: 19622729
  10. the expression, localization, and inflammation-induced alterations of sst(4) receptors in murine and human lungs PMID: 19687471

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Database Links
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