Recombinant Rat ATP-sensitive inward rectifier potassium channel 8 (Kcnj8)

1. it can be concluded that mitoKATP channels regulate mitochondrial dynamics to participate in rotenone-induced Parkinson's disease mainly attributes to the pore subunits of Kir6.1. PMID: 29353068
2. In vascular smooth muscle KATP channel subunits Kir6.1 and SUR2B contribute to modify the functionality of this channel in hypertension with age. PMID: 27035370
3. both Kir6.1(V65M) and Kir6.2(V64M) mutations essentially abolish high-affinity sensitivity to the KATP blocker glibenclamide in both intact cells and excised patches. This raises the possibility that, at least for some CS mutations, sulfonylurea therapy may not prove to be successful and highlights the need for detailed pharmacogenomic analyses of CS mutations. PMID: 28842488
4. Our results suggest that pretreatment with 0.5 MAC sevoflurane is as effective as IPC against intestinal ischemia-reperfusion injury. The activation of PKC and mKATP may be involved in the protective mechanisms of SPC. PMID: 26505750
5. Suggest that the increase in KATP channel subunits, SUR2 and Kir6.1, in the rostral ventrolateral medulla may be responsible for the greater sympathetic outflow and pressor effect of hydroxylamine in Ad-cystathionine beta-synthetase injected rats. PMID: 25599573
6. ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variant PMID: 24037327
7. Kir6.1 overactivity in vascular muscle can lead directly to reduced vascular contractility and lower blood pressure. PMID: 23974906
8. Data indicate that activation of mitoK(ATP) channel decreased the latency time of the transjunctional currents by 50%. PMID: 23418587
9. Tempol attenuates the exercise pressor reflex in rats with ligated femoral arteries via effects on K(ATP) channels. PMID: 22636679
10. Ischemia-reperfusion injury in the rat testis significantly increased the expressions of Kir6.1 protein and mRNA as well as Kir6.2 mRNA. PMID: 22480512
11. K(ATP) channel subunits Kir6.1, Kir6.2, SUR1 and SUR2B were identified in the trigeminal ganglia and trigeminal nucleus caudalis. PMID: 22144717
12. Vascular KATP channels (Kir6.1/SUR2B) are inhibited by oxidative stress. This paper found the inhibition is through a covalent modification of the channel protein, i.e., S-glutathionylation of a cysteine residue (Cys-176) on the Kir6.1 subunit. PMID: 21216949
13. Guanxinkang injection significantly increased mRNA and protein expressions of Kir6.1, Kir6.2, SUR2A and SUR2B in ischemic myocytes but with no significant difference compared to pinacidil. PMID: 20456845
14. Data identified glycolytic enzymes GAPDH and aldolase A as putative interacting proteins for cardiac ATP-sensitive potassium (K(ATP)) channels. PMID: 21482559
15. Interaction of caveolin-1 functionally regulates the activity of the vascular subtype of potassium KATP channel Kir6.1. PMID: 20624795
16. Lipopolysaccharides up-regulate Kir6.1/SUR2B channel expression and enhance vascular KATP channel activity via NF-kappaB-dependent signaling PMID: 19959479
17. Data suggest that sarc and mitoKATP channel populations play distinct protective roles, triggered by PKC and/or adenosine, during chemically induced hypoxia/reoxygenation. PMID: 11726534
18. there are at least two putative mesangial KATP that most likely represent hetero-octamers, comprised of either rSUR2B or mcSUR2 in complex with Kir6.1. PMID: 11967023
19. Results report the expression of four K(ATP) subunits in vascular tissues, unmasking the diversity of native K(ATP) channels in vascular SMCs. PMID: 12163042
20. Kir 6.1 gene expression is induced by urocortin in cardiac myocytes PMID: 12234964
21. Kir6.1 channel subunits are highly expressed during early development of ureteric bud and nephron epithelia where Kir6.1 activity regulates cell proliferation. PMID: 12466933
22. Intracellular acidification may produce dilatation of the basilar artery through activation of ATP-sensitive potassium channels in vivo. Kir6.1/SUR2B may be the major potassium channels that mediate propionate-induced dilatation of the artery. PMID: 12677015
23. Kir6.1 protein is found in a small subset of neurons in distinct areas of the brain, like the hypothalamic supraoptic and paraventricular nuclei and the striatum. Kir6.1-positive neurons in the striatum could be characterized as cholinergic interneurones PMID: 12965237
24. The expression of Kir6.1 and SUR2B mRNAs was observed in small and intermediate arteries as well as arterioles in several tissues, including basilar, vertebral, mesenteric, coronary and renal arteries. PMID: 14724757
25. KIR6.1 may associate with KIR6.2 to form heterotetrameric pores of native K(ATP) channels in cardiomyocytes. PMID: 15044189
26. Kir6.1-like immunolabeling is restricted to astrocytes in most areas of the rat brain and very weak or absent in neurons. PMID: 15739238
27. Channel opening in isolated rat heart mitochondria slightly decreased Ca(2+) uptake and prevented mitochondrial reactive oxygen species production. PMID: 15906152
28. Results describe a new function of the Kir6.1-SUR2A complex, namely the regulation of paracellular permeability through tight junctions. PMID: 16820413
29. Long-term regulation of ENaC and CFTR expression by Kir6.1 channel activity could benefit patients with pulmonary diseases affecting ion transport and fluid clearance. PMID: 16891388
30. Mouse hearts expressing an endothelial rat Kir6.1 transgene exhibited elevated coronary perfusion pressure due to increased endothelin-1 secretion. K(ATP)channels may control coronary circulation by modulating endothelin-1. PMID: 17341678
31. Expression of the conductance subunit Kir6.1 was increased up to 3-fold in cardiomyocytes from the infarct border zone. PMID: 17512536
32. Kir6.1 is localized in kidney epithelial cells, glomerular mesangial cells, and smooth muscles of blood vessels; subcellular loclization is mainly in the mitochondria, endoplasmic reticulum, and very weakly in cell membranes PMID: 17548268
33. Nitric oxide can directly activate the cardiac mitoK(ATP), which may underlie its contribution to myocardial preconditioning. PMID: 17714708
34. These results therefore indicate that the vascular isoform (Kir6.1/SUR2B) of KATP channels is a target of vasoactive intestinal polypeptide. PMID: 17942071
35. a motif containing four phosphorylation repeats is identified in the Kir6.1 subunit underlying the PKC-dependent inhibition of the Kir6.1/SUR2B channel PMID: 18048350
36. FoxF2 and -O are key transcription factors coordinating expression of KATP channels and energy metabolism. PMID: 18202312
37. Our data demonstrate direct evidence of decreased aortic Kir6.1 subunit expression in hypertension PMID: 18471810
38. These findings suggest that the adenosine triphosphate-dependent potassium channel is downregulated in smooth muscle cells from the aortas of obese rats, which may contribute to the increase in blood pressure in these rats. PMID: 19056241

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KEGG: rno:25472

STRING: 10116.ENSRNOP00000018057

UniGene: Rn.229203