CALCRL (Erenumab Biosimilar) Recombinant Monoclonal Antibody

1. Single nucleotide polymorphism of CRLR is associated with Stroke. PMID: 28904253
2. These findings confirm the role of the stalk region in peptide binding but also provide further evidence that G protein-coupled receptor (GPCR) and adrenomedullin interact differently with CLR, with CGRP forming closer contacts with the stalk than adrenomedullin. PMID: 29388762
3. This study revealed for the first time an increase of mast-nerve association and CGRPR expression on mast cells during AR as well as nerve fibres containing receptors for mast cells. PMID: 28030866
4. Data suggest CGRP receptor (CGRPR) ECL2 (extracellular loop 2 domain) enables interaction with N-terminal residues of CGRP; this provides evidence for dual involvement of ECL2 in two-domain binding model of CGRP/CGRPR interaction; CGRPR is obligate heterodimer of CLR/RAMP1. (CGRP = calcitonin gene-related peptide; CLR = calcitonin receptor-like receptor; RAMP1 = receptor [calcitonin] activity modifying protein 1) PMID: 28691801
5. Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3. PMID: 27553639
6. interaction of RAMP2 or RAMP3 with CLR induces conformational variation in the juxtamembrane region, yielding distinct binding pockets, probably via an allosteric mechanism. PMID: 27013657
7. STC1 interferes with CALCRL signaling during osteoblastogenesis via adenylate cyclase inhibition. PMID: 25591908
8. Data suggest that ligand binding of a G protein-coupled receptor (GPCR) may inform drug development targeting calcitonin receptor-like receptor (CLR):receptor activity-modifying proteins RAMP1/2 complexes. PMID: 25982113
9. the AM system is widely expressed in human thymus from newborns; both AM1 receptor components CLR and RAMP2, but not RAMP3, are not associated with the plasma membrane of TECs and thymocytes but are located intracellularly, notably in the nucleus PMID: 24831942
10. Two CALCRL variants were associated with risk for gestational diabetes. PMID: 23797962
11. Data suggest isoforms of RAMP (receptor activity-modifying protein) modulate accessibility of peptides to residues situated on CALCRL N-terminal domain; RAMP3/RAMP2/RAMP1 appear to alter accessibility of specific residues at CALCRL-RAMP interface. PMID: 24199627
12. CRLR expression is upregulated in the fetal lung with increasing gestational age. PMID: 24169318
13. The G-protein-coupled receptor CLR is upregulated in an autocrine loop with adrenomedullin in clear cell renal cell carcinoma and associated with poor prognosis. PMID: 23969937
14. An alanine scan of residues 271-294 of CLR showed that the ability of CGRP to produce cAMP was impaired by point mutations at 13 residues; most of these also impaired the response to adrenomedullin (AM). PMID: 24047872
15. The study implicates genetic variation at the CALCRL gene in the pathogenesis of primary angle closure glaucoma in an Australian Caucasian cohort. PMID: 22933837
16. CLR and RAMP1 co-localize in the enteric nervous system of the stomach, ileum and colon, and are in close proximity to their ligands CGRP and IMD PMID: 22484227
17. This study showed that CLR immunoreactivity was observed in satellite glial cells (SGCs) as well as in nerve fibers, but not in neurons. PMID: 22208649
18. human CLR ECL3 is crucial for adrenomedullin (AM)-induced cAMP responses via three CLR/RAMP heterodimers, and activation of these heterodimers probably relies on AM-induced conformational changes PMID: 22142144
19. The CRLR-RAMP2 interactions were confirmed for the full-length proteins on the cell surface by site-specific photo-crosslinking. PMID: 22102369
20. Unexplained infertility was characterised by lower number of vessels stained with CRLR in endometrium compared to fertile controls. PMID: 20954838
21. Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function. PMID: 21703310
22. Structure-function analysis of helix 8 of human calcitonin receptor-like receptor within the adrenomedullin 1 receptor PMID: 20946927
23. Data describe the role of residues 23-60 of the calcitonin receptor-like receptor in binding with interaction sites within the N-terminus of the calcitonin gene-related peptide receptor. PMID: 19913063
24. the hCRLR C-tail is crucial for adrenomedullin-evoked cAMP production and internalization of the CRLR/RAMP2, while the receptor internalization is dependent on the aforementioned GPCR kinases, but not Gs coupling. PMID: 20074556
25. Intrinsic cardiac adrenergic cells constitute a delta-opioid-regulated adrenopeptidergic paracrine system conferring robust cardioprotection through beta(2)-AR/CGRP-R co-signalling. PMID: 19581316
26. Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands. PMID: 19903822
27. Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells PMID: 11693189
28. This study aimed to identify the cellular location of calcitonin receptor-like receptor (CRLR) which is pharmacologically identical to CGRP receptor-1, a putative molecular target of CGRP and adrenomedullin PMID: 11814625
29. The CGRP receptor components, RAMP1 and CRLR, are down-regulated during myeloid differentiation of CD34+ cells, and CGRP receptor selectively promotes the development of CFU-GM. PMID: 11937264
30. results show the presence of calcitonin receptor-like receptor and receptor activity-modifying proteins in middle meningeal, middle cerebral, pial, and superficial temporal vessels PMID: 11973435
31. expression at the human implantation site PMID: 12213903
32. receptor activity-modifying protein 1 binds to the CRLR PMID: 12574158
33. Cysteine residues in the extracellular loops of hCRLR and in the extracellular domain of hRAMP2 thus appear to play distinct roles in the cell surface expression and function of the receptor heterodimer. PMID: 12630808
34. findings show that human skin keratinocytes and fibroblasts express adrenomedullin and its receptors L1-R and CRLR PMID: 12684703
35. Transcriptional regulation of the CRLR gene in microvascular endothelial cells by hypoxia. PMID: 12824306
36. TNF-alpha induced time- and dose-dependent decreases in the expression of CRLR mRNA in cultured human coronary artery smooth muscle cells, thereby diminishing AM-evoked cAMP production PMID: 15245870
37. Results demonstrated in the atria of heart failure patients there is an up-regulation of CGRP receptor by an increase of RAMP1 in association with CRLR. PMID: 15300632
38. novel function for RAMP3 in the post-endocytic sorting of the calcitonin receptor-like receptor. PMID: 15613468
39. The N-terminal domain of calcitonin receptor-like receptor is an autonomously folded unit possessing a well-defined structure and is significantly involved in ligand binding and specificity. PMID: 15641806
40. among women, the T allele of the SNP rs696574 (C --> T, in intron 6) was significantly more frequent in essential hypertension subjects PMID: 15797661
41. Structural and functional characteristics of the CGRP-receptor and of family B G-protein-coupled receptors in general. PMID: 16293613
42. the respective C-tails of hRAMP2 and -3 differentially affect hCRLR surface delivery and internalization PMID: 16410241
43. adrenomedullin may prevent or reduce rheumatoid arthritis-fibroblast-like synoviocyte apoptosis, via up-regulation of its functional receptor CRLR/receptor activity-modifying protein-2 PMID: 16622024
44. Results will facilitate structural analysis of the recombinant protein will facilitate structural analysis of human RCP (receptor component protein), and allow further understanding of RCP function PMID: 17067815
45. CLR and RAMP1 traffic from endosomes to lysosomes by ubiquitin-independent mechanisms, where they are degraded at different rates PMID: 17310067
46. A mutated RAMP1 that cannot reach the cell surface, even in the presence of CRLR, indicating that the deficient targeting resulted from the altered conformation of the complex. PMID: 17503773
47. HRS mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor PMID: 17675298
48. Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of RAMP1. PMID: 17785463
49. There were some differences in mRNA expression for CL-R (higher) and RAMP3 (lower) in middle cerebral artery compared to coronary artery and pulmonary artery. PMID: 18198792
50. findings provided no significant linkage or association of adrenomedullin and CRLR-RAMP-2 genes with rheumatoid arthritis in the studied trio families PMID: 19210874

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HGNC: 16709

OMIM: 114190

KEGG: hsa:10203

STRING: 9606.ENSP00000376177

UniGene: Hs.470882