CD200 (Samalizumab Biosimilar) Recombinant Monoclonal Antibody

1. overexpression of human CD200 in donor pigs could constitute a promising strategy for overcoming xenograft rejection. PMID: 28968355
2. Our results support the fact that CD200 can be added to routine Chronic lymphoproliferative disorders panel as it is useful in subcategorizing them. However, inclusion of CD20 ABC to routine panel does not seem plausible but may be done for difficult diagnostic cases or where anti-CD20 therapy is planned. PMID: 29567884
3. A diligent morphological examination to look for the presence of hairy cells along with flow cytometric immunophenotyping showing consistent bright expression of CD200, in addition to well-described characteristic immunophenotype, helps in correctly diagnosing the case. This can be further confirmed by the consistent presence of V600E point mutation in BRAF gene. PMID: 30197362
4. CD200(+) and/or CD56(+) positive expression in B-ALL patients at diagnosis is a poor prognostic biomarker. PMID: 29161980
5. CD200 was expressed in 97.3% of atypical chronic lymphocytic leukemia cases, whereas it was dimly expressed in only 6.1% of mantle cell lymphoma cases. PMID: 28713070
6. CD200 and/or CD56 positive expression in B-ALL at diagnosis suggest a poor prognosis and may be associated with biological aggressiveness. PMID: 29144828
7. downregulation of CD200 expression resulted in an imbalance of increased Th1 cytokine and decreased Th2 cytokine production in placental trophoblasts in preeclampsia PMID: 28940677
8. This is the first report of CD200 mRNA and protein expression in patients with transitional cell carcinoma of the human bladder. TCC tissues showed significantly higher CD200 expression than normal bladder tissues. CD200 signals were also higher in metastasized compared to localized TCC. The data provide a strong indication for a putative role of CD200 in the immune-evasion of bladder cancer. PMID: 29715095
9. Our data confirm a negative impact of ABCG2 and CD200 overexpression also in AML patients considered at favorable risk according to ELN cytogenetic/molecular classification. PMID: 28618016
10. Residual CD200 activity may prevent completion of abortions via induction of Treg cells. In chronic histiocytic intervillositis, infiltrating maternal effector T cells may block Treg induction. An autocrine role for CD200-CD200R interaction versus inhibition of soluble CD200 by soluble CD200R is discussed. PMID: 28326648
11. patients with Autosomal dominant polycystic kidney disease have activated soluble CD200 levels which were related to renal function and inflammation. PMID: 28179401
12. correlation of sCD200 serum levels with COPD-related parameters in humans with established disease revealed that the CD200/CD200R axis may be mechanistically linked to the disease course in COPD patients. PMID: 27864635
13. It suppresses macrophage-mediated xenogeneic cytotoxicity and phagocytosis. PMID: 28573328
14. High expression of CD200 is associated with chronic lymphocytic leukemia. PMID: 26910908
15. It is a anti-inflammatory protein. PMID: 28390825
16. CD200 expression therefore may be used to help identify pulmonary small cell carcinoma in flow cytometry specimens. PMID: 26584149
17. Our data suggest a negative impact of CD200 expression in cytogenetically-normal acute myeloid leukemia PMID: 28407515
18. CD200 was expressed in 87% of the neuroendocrine neoplasms studied. CD200 is a relatively sensitive marker of neuroendocrine neoplasms and represents a potential therapeutic target in these difficult-to-treat malignancies. PMID: 28821198
19. Up-regulation of CD200 in MDS predicts poor prognosis. PMID: 28152413
20. this study shows that that CD200 suppresses the immune system's response to vaccines, and that blocking CD200 could improve the efficacy of cancer immunotherapy PMID: 27485078
21. These results suggest that CD200S activates TAMs to become DC-like antigen presenting cells, leading to the activation of CD8(+) cytotoxic T lymphocytes, which induce apoptotic elimination of tumor cells. PMID: 27108386
22. increased expression of CD200, expansion of suppressive Treg cells and elevation of cytokines might have a role in multiple myeloma progression PMID: 26033514
23. In the present study, we showed for the first time a correlation between CD200 expression and the Wnt signaling pathway in colon cancer cells. PMID: 27574016
24. data confirms that a functionally active CD200 extracellular moiety can be cleaved from the surface of CD200 expressing cells following ectodomain shedding PMID: 27111430
25. CD200 is a poor prognostic factor for overall survival in multiple myeloma (MM) patients. Bone marrow CD3 lymphocytes from MM patients express CD200 protein in higher proportion than healthy donors. PMID: 26177431
26. CD200 expression by cultured cultured bone marrow mesenchymal stem cells can be induced by both osteogenic and pro-inflammatory cytokines through the sole NF-kappaB pathway. PMID: 26773707
27. suggest that microglial activation may be partially caused by CD47/signal regulatory protein-alpha- and CD200/CD200R-mediated reductions in the immune inhibitory pathways PMID: 27095555
28. CD200 is up-regulated and may be a novel biomarker for the prognosis in cutaneous squamous cell carcinoma. PMID: 27035797
29. CD200 expression is a useful marker for evaluation of the severity of PCM and that lack of CD200 expression may improve the sensitivity of PCM to therapy with new drugs. PMID: 26763359
30. the combination of CD200 and CD148 may have a potential differential diagnostic value in leukemic B-CLPDs, especially between CLL and MCL. PMID: 25791119
31. CD200-CD200R1 signaling may be required for human pregnancy success. PMID: 26123445
32. CD200 signaling may play a key role in regulating macrophage polarization toward anti-inflammatory phenotypes PMID: 26670206
33. Suggest CD200 as both prognostic factor and potential therapeutic target AML, aiming to reverse the "do not eat me" signal of CD200 or to manipulate the suppressive immune microenvironment induced by CD200 binding to its receptor. PMID: 26338961
34. CD160 and CD200 are expressed in B cells in chronic lymphocytic leukemia and are absent in other mature B-cell neoplasms. PMID: 25470765
35. our study confirms that CD200/BTLA deletions are recurrent genetic lesions in the biology of BCP-ALL PMID: 26137961
36. CD200 antigen expression features response for chemoradiation in patients squamous cell head and neck cancer. PMID: 24700450
37. CD200 expression by early-stage human breast cancer cells in primary tumors did not correlate with increased regional lymph node metastasis. PMID: 25041579
38. The proportion of CD200+ cells in PBMCs, peripheral CD14+ cells and CD4+ T cells was significantly lower in rheumatoid arthritis patients compared to controls, whereas the number of CD200+ cells was higher in synovium from RA patients than from controls. PMID: 25261692
39. Prognostic value of CD200 detected in malignant ascites from patients with metastatic ovarian, endometrial and breast neoplasms remains to be elucidated. PMID: 25778329
40. We demonstrate a significant correlation between CD200R1 positive cells and disease severity in rheumatoid arthritis (RA) patients, thus indicating the relevance of the CD200/CD200R1 signaling pathway potential involvement in the pathogenesis of RA. PMID: 24496593
41. The mechanism underlying ESA might be associated with enhanced expression of CD200 and CD200R in the trophoblast, leading to an upregulation of the immune response during the first trimester of pregnancy. PMID: 25145957
42. The results expand the understanding of the CD200 expression in mature B-cell neoplasms , giving further support for the inclusion of this marker in the routine investigation by flow cytometry. PMID: 24243815
43. staining by flow cytometry can be useful in the differential diagnosis of B-cell neoplasms and in their detection in the bone marrow PMID: 25389338
44. CD200 is expressed in a majority of plasma cell myeloma cases, and the expression is stable during the treatment process. PMID: 24958785
45. The soluble OX-2 levels of type 2 diabetic foot were compared with that of healthy controls. PMID: 24964809
46. The expression of CD200 as well as B7-H4 co-stimulatory molecules on CD14(+) cells were significantly higher in cord blood when compared with peripheral blood. PMID: 23066977
47. Measurement of sCD200 and/or sCD200R1 may prove a useful and rapid means of monitoring subjects at risk of bone loss. PMID: 24333170
48. expression of CD200 in the bone marrow of chronic lymphocytic leukemia PMID: 24405602
49. [review] Inhibitory receptors are separated into two major classes based on their extracellular domains: immunoglobulin (Ig) and carbohydrate-binding C-type lectin families. PMID: 24388216
50. Soluble CD200 might play a role in immune response in the pathogenesis of autoimmune and inflammatory skin disorders. PMID: 24157657

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HGNC: 7203

OMIM: 155970

KEGG: hsa:4345

STRING: 9606.ENSP00000420298

UniGene: Hs.79015