CD248 (Ontuxizumab Biosimilar) Recombinant Monoclonal Antibody

1. These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation PMID: 28671670
2. Data show that podoplanin (PDPN), CD106 (VCAM-1) and CD248 protein were increased in diseased compared to healthy tendon cells. PMID: 28122639
3. the data demonstrate a critical role for endosialin-expressing primary tumor pericytes in mediating metastatic dissemination and identify endosialin as a promising therapeutic target in breast cancer PMID: 27635044
4. Endosialin is a potential regulator of phenotypic remodeling of vascular smooth muscle cells contributing to atherosclerosis. PMID: 28126825
5. Tumour cell endosialin expression was seen in 89% of undifferentiated pleomorphic sarcomas, 77% of adult fibrosarcomas/spindle cell sarcomas, 62% of synovial sarcomas, 51% of leiomyosarcomas and 31% of rhabdomyosarcomas. PMID: 27434038
6. CD248 overexpression is possibly involved in the pathogenesis of IPF and it has potential as a disease severity marker. PMID: 27080864
7. TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer PMID: 26336878
8. MORAb-004 reduced CD248 on pericytes, impaired tumor microvasculature maturation and ultimately suppressed tumor development. PMID: 26327620
9. The authors show that endosialin, a C-type lectin, expressed in the liver exclusively by HSC and portal fibroblasts, is upregulated in liver fibrosis in mouse and man. PMID: 25680861
10. The genes CD248, Ephb1 and P2RY2 were detected as the top overexpressed in GC biopsies. PMID: 24716914
11. new monoclonal antibodies described in this paper are domain-specific and represent important reagents for the study of functional contributions of extracellular endosialin domains PMID: 22824847
12. [review] CD248 is a C-type lectin-like domain-containing cell surface glycoprotein that is expressed by stromal cells of proliferating tissues during embryogenesis and postnatally in tumors and inflammatory lesions. PMID: 22206249
13. CD248 defines a subset of stromal cells, including but not limited to some myofibroblasts, linked to albuminuria and tubulointerstitial damage during tissue remodeling in CKD. PMID: 21490589
14. endosialin can be detected in advanced sarcoma PMID: 21537839
15. Endosialin expression may be involved in the progression of rectal cancers. PMID: 21362178
16. Results provide evidence for a TEM-1-dependent signal pathway that controls proliferation of pericytes. PMID: 20484976
17. TEM1/endosialin was induced in the vasculature of high-grade brain tumors where its expression was inversely correlated with patient age. PMID: 19948061
18. Endosialin colocalized with thrombomodulin, suggesting the proteins may have complementary functions in tumor progression. PMID: 15624764
19. Endosialin is a marker of stromal fibroblasts and is not selectively expressed on tumor endothelium. PMID: 15862292
20. results pinpoint to a molecular mechanism by which expression of endosialin/TEM1 in the tumor stroma and endothelium may support tumor progression and invasion PMID: 17986615
21. experiments unambiguously demonstrate that endosialin is expressed by tumor-associated myofibroblasts & mural cells & not by endothelial cells; results validate endosialin as marker of tumor-associated myofibroblasts & tumor vessel-associated mural cells PMID: 18187565
22. endosialin is not expressed in normal human adult brain but is strongly upregulated in the angiogenic vasculature of all high-grade glioma specimens examined PMID: 18192970
23. identified extracellular endosialin ligands and identified Mac-2 BP/90K as a specific interaction partner PMID: 18490383
24. expression of TEM1 or endosialin (CD248) and other TEM has been discovered in a population of vascular endothelial growth factor receptor 2+/CD31+/CD45-/VE-cadherin+ EPC derived from human CD133+/CD34+ cells PMID: 18723498
25. endosialin is strongly expressed by pericytes during periods of active angiogenesis during embryonic and tumor development PMID: 18761022
26. These findings elucidate important aspects of endosialin gene regulation PMID: 18813310

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HGNC: 18219

OMIM: 606064

KEGG: hsa:57124

STRING: 9606.ENSP00000308117

UniGene: Hs.195727