CD4 (Semzuvolimab Biosimilar) Recombinant Monoclonal Antibody

1. CD4 receptor levels are very low in THP-1 differentiated cells and that this down-regulation of the virus receptor is the result of miR-221/miR-222 up-regulation during differentiation. In THP-1 cell line stably expressing a modified CD4 that is not modulated by miR-221/miR-222, productive HIV-1 infection occurs after cell differentiation. PMID: 29301198
2. Human BD-2 and BD-3 play a positive and negative regulatory role in development and proliferation of human effector CD4+ T cells which is essential for optimal adaptive immune responses and the control of immunopathology. PMID: 30098283
3. These findings highlight regions of cross talk between gp120 and gp41 and identify heptad repeat region 1(HR1) residues that play important roles in regulating CD4-induced conformational changes in Env. PMID: 29875245
4. CD4(+) and CD19(+) peripheral lymphocytes of early stage AD patients exhibit mitochondrial depletion, as seen both at the level of DNA and protein PMID: 28923392
5. Human microRNAs-221 and -222 inhibit HIV-1 entry in macrophages by targeting the CD4 viral receptor. PMID: 28978468
6. CD4 has four ecto-domains (D1-D4), D1, D2, and D4 each contain a distinctive disulfide bond. Reduction of D2 disulfide decreases the dynamics of its surrounding beta-strands. Favorable inward collapse of structure occurs around the D2 disulfide after reduction. PMID: 29470989
7. Our results indicate that CD4 expression and older age are adverse prognostic factors in wild-type NPM1, FLT3-ITD-negative CN-AML. PMID: 28318150
8. We investigated the prevalence, magnitude and phenotype of CTAg-specific T cells in the blood of patients with testicular germ cell tumors (TGCTs). CD8(+) and CD4(+) T-cell responses against MAGE-A family antigens were present in 44% (20/45) of patients' samples assayed by ex vivo IFN-gamma ELISPOT. Spontaneous T-cell immunity against CTAg proteins therefore develops in many patients with testicular cancer. PMID: 28555838
9. Depletion of the gamma2 or mu1A (AP1M1) subunits of AP-1, but not of gamma1 (AP1G1), precludes Nef-mediated lysosomal degradation of CD4. PMID: 27909244
10. findings provide a mechanistic explanation for previous observations that dimerization-defective Nef mutants fail to down-regulate CD4 and validate the Nef dimerization interface as a target site for antiretroviral drug development PMID: 28031466
11. Mouse leukemia cell lines that could express hCD4 and CCR5 were thus established to facilitate normal entry of HIV-1 so that a human CD4/CCR5 transgenic mice cell model can be used to investigate the transmission and pathogenesis of HIV/AIDS and potential antiviral drugs against this disease. PMID: 28028680
12. The percentage of lamina propia CD4+LAP+ cells is increased in active ulcerative colitis, showing reduced suppressor activity due to their increased proportion of intracellular IL-17 expression. PMID: 26589955
13. possible therapeutic targets for childhood severe asthmatics identified thru DNA microarray PMID: 25979195
14. The study gives insights into the role of CD4 on cell membrane mechanical characteristics. PMID: 26362701
15. A decrease of CD4(+) CD25(+) CD127(low) FoxP3(+) regulatory T cells with impaired suppressive function had been found in untreated ulcerative colitis patients. PMID: 26333292
16. Redox shuffling of the allosteric disulfide results in previously undescribed conformational changes in CD4 that are likely important for its interaction with its protein partners. PMID: 27009680
17. Increased levels of activated and highly susceptible HIV-1 target cells, reduced CD4 and enhanced CXCR4 cell surface expression, together with the high susceptibility to FAS-induced programmed cell death may contribute to the rapid CD4+ T cell depletion. PMID: 26452480
18. HRB knock-down affected CD4 downregulation induced by Nef but not by HIV-1 Vpu. PMID: 26701340
19. Increased CD4, IL-17, and COX-2 expression are associated with subclinical inflammation in malar melasma. PMID: 26381025
20. CD4 receptor induced HIV size expansion prior to cell entry. PMID: 26432024
21. Sustained expression of CD83 was observed when CD4+ T cells were induced by transforming growth factor-beta to differentiate into CD4+CD25+ forkhead box P3+ regulatory T (iTreg) cells. PMID: 25997495
22. CHD in Chinese population is strongly associated with HLA-DRB1*01 and DRB1*04 haplotypes, and formation of CD4(+)CD28(null) T cells was related to HLA-DRB1*01, DRB1*04, and DRB1*15 alleles. PMID: 20842443
23. These results lead to a model for the docking of the full AP-2 tetramer to membranes as bound to Nef, such that the cytosolic tail of CD4 is situated to interact with its binding site on Nef. PMID: 24473078
24. This study demonstrates a null association between the CD4 C868T polymorphism and an individual's susceptibility of HIV-1 acquisition in a Chinese population. PMID: 25611551
25. Nicotine ameliorates experimental severe acute pancreatitis via enhancing immunoregulation of CD4+ CD25+ regulatory T cells. PMID: 25742430
26. T-cell receptor activation of human CD4(+) T cells shifts the innate toll-like receptor response from CXCL8(hi) IFN-gamma(null) to CXCL8(lo) IFN-gamma(hi). PMID: 26205220
27. Nef domains involved in CD4 downregulation were necessary for activation of plasmacytoid dendritic Cell. PMID: 25972534
28. Here, we describe the HIV care cascade and ART delivery supply chain to examine how mathematical modeling can provide insight into cost-effective strategies for scaling-up ART coverage in sub-Saharan Africa and help achieve universal ART coverage. PMID: 25249293
29. Rapidly translating new science into policy is a critical component of the HIV response. Adapting and implementing the 2013 WHO treatment recommendations are necessary to prevent unnecessary illness, death, HIV transmission and costs. PMID: 25266850
30. To augment the literature, we present a review of ART adherence interventions from 2013 to the present. We included peer-reviewed journals as well as abstracts from two key conferences. PMID: 25304006
31. Earlier access of key populations to combination prevention interventions, combined with sustained political commitment and supportive environment for key populations, are essential for maximum impact of ART on the HIV epidemic in Vietnam. PMID: 25472886
32. The study shows that activated CD4+ T cells can produce 1,25(OH)2D3, and that 1,25(OH)2D3 induces a 2-fold up-regulation of the VDR protein expression in activated CD4+ T cells by protecting the VDR against proteasomal degradation. PMID: 24792400
33. Data indicate that CD4 antigen binding disrupts quaternary interactions at the HIV-1 Env trimer apex. PMID: 24931470
34. the multi-faceted role of human SP-D against HIV-1 PMID: 25036364
35. The effects of HIV Nef protein on down regulation of CD4 and HLA class I in patients with early and chronic HIV infection with HIV-1 subtype C is reported. PMID: 25193656
36. The current review contributes to a better understanding of the role of AhR and its signaling pathway in CD4 helper T cell mediated inflammatory disorder. [review] PMID: 24905409
37. Authors determined that the activation of CD4 via interaction with major histocompatibility complex class II (MHC-II) triggers cytokine expression and the differentiation of human monocytes into functional mature macrophages. PMID: 24942581
38. HIV-1 Nef interacts with Alix in late endosomes, and this is required for efficient lysosomal targeting of CD4. PMID: 25118280
39. Human tumor-infiltrating CD4+CD69+ T cells suppress T cell proliferation via membarene -bound TGF-beta1. PMID: 24668348
40. These results demonstrate that aptamer-facilitated cell specific delivery of shRNA represents a novel approach for efficient RNAi delivery and is potentially to be developed for therapeutics targeting specific T cells subtypes. PMID: 25241192
41. data show that Ag-specific CD4(+) CD25(+) CD134(+) CD39(+) T cells are highly enriched for Treg cells, form a large component of recall responses and maintain a Treg-cell-like phenotype upon in vitro expansion. PMID: 24752698
42. Binding of the HIV-1 envelope protein gp120IIIB to the CD4/CXCR4/CCR5 heterooligomer was negligible, and the gp120-induced cytoskeletal rearrangements necessary for HIV-1 entry were prevented. PMID: 24778234
43. Using biopsies from H. pylori-positive patients, PCR was used to quantify the expression of Foxp3 mRNA and IHC was used to semi- quantify the number of CD4+ CD25+ T cells in gastric mucosa. PMID: 24901172
44. HIV glycoprotein 120 (gp120) requires disulfide reduction in CD4 domain 1 or 2 which impairs thioredoxin-driven CD4 dimerization PMID: 24550395
45. this study identifies a novel mechanism of Chronic heat stress immunosuppression mediated by regulating CD4 CD25 Foxp3 Tregs. PMID: 24151582
46. The acquisition of B cell stimulating properties by naive cord blood CD4 T cells required the STAT3-dependent expression of ICOS and IL-21. PMID: 23923047
47. CD4 retro-translocates with oxidized intrachain disulfide bridges, and only upon proteasomal inhibition does it accumulate in the cytosol as already reduced and deglycosylated molecules. PMID: 24257748
48. CD4(+)CD25(+)FOXP3(+) Treg levels were lower in Kawasaki disease patients than healthy subjects, and levels before treatment were lower in intravenous immunoglobulin (IVIg)-resistant patients than in IVIg-sensitive patients. PMID: 23340699
49. The CD4(372-433) peptide fragment in the given sample undergoes some rotational averaging of anisotropic interactions; additional amino acid type-specific assignments are achieved for 10 amino acid spin systems for both CD4(372-433) and Vpu. PMID: 23863698
50. sCD4 might be considered an important parameter for RA disease progression with potential diagnostic importance. PMID: 23700441

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HGNC: 1678

OMIM: 186940

KEGG: hsa:920

STRING: 9606.ENSP00000011653

UniGene: Hs.631659