DPP3 (Procizumab Biosimilar) Recombinant Monoclonal Antibody

1. We conclude that DPP 3 may influence the cellular expression of Ang-(1-7) and potentially reflect a therapeutic target to augment the actions of the peptide PMID: 27315786
2. biological function of human dipeptidyl peptidase III PMID: 26887037
3. several crystal structures of complexes of human dipeptidyl peptidase III with different peptides. PMID: 27025154
4. Evidence for concurrent expression of hDPP III mRNA V-I and V-II in multiple human tumor derived cell lines. PMID: 27153830
5. the DPP III conformational landscape and the influence of ligand binding on the protein structure and dynamics, was investigated. PMID: 26334575
6. Kinetic studies revealed that the single mutant D496G lost selectivity due to the increase of the Km value. The D496G, but not S504G, showed significantly decreased binding of peptides with N-terminal arginine, and of tynorphin. PMID: 25581752
7. The study used three different conformations of human dipeptidyl-peptidase III (DPP III) to investigate the influence of the protein environment on ligand binding and the Zn(2+) coordination. PMID: 25192149
8. Deletion/mutagenesis of C/EBP-beta binding motif of DPP III promoter significantly increased its activity and abolished its responsiveness to IL-6 in glioblastoma cells. PMID: 24472318
9. The activity of the yeast and human dipeptidyl peptidase III were examined. PMID: 23362197
10. Combined results of mutational analysis and mass spectrometry suggest that glutathionylation (formation of mixed disulfide) of Cys176 and Cys654 contributes to human DPP III inactivation by oxidized glutathione. PMID: 23667907
11. Amplification and mRNA overexpression of the DPP3 gene is associated with squamous cell lung carcinomas. PMID: 23382044
12. results provide the basis for the design of specific inhibitors that enable the elucidation of the exact role of DPP III and the exploration of its potential as a target of pain intervention strategies PMID: 22493238
13. Ets-1/Elk-1 is a critical mediator of DPP3 transcription in human glioblastoma cells. PMID: 20236318
14. In malignant neoplasms of the ovary DPP III activity increased with growing histologic grade. PMID: 14529681
15. the conserved tyrosine could be involved in transition state stabilization during the catalytic action of M49 peptidases. PMID: 18163885

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HGNC: 3008

OMIM: 606818

KEGG: hsa:10072

STRING: 9606.ENSP00000353701

UniGene: Hs.502914