Name: HAP1 (Calpurbatug Biosimilar) Recombinant Monoclonal Antibody
Brand: CUSABIO
SKU: CSB-RA010129MB1HU

Product Details

Uniprot No.

P54257

Target Names

HAP1

Alternative Names

TRL1068 research-grade biosimilar; TRL 1068 research-grade biosimilar; TRL-1068 research-grade biosimilar ;HAP1 antibody; HAP2 antibody; HLP1 antibody; Huntingtin-associated protein 1 antibody; HAP-1 antibody; Neuroan 1 antibody

Species Reactivity

Human

Immunogen

Recombinant Human HAP1 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Description

This recombinant monoclonal antibody is designed as a research-grade biosimilar to Calpurbatug, targeting HAP1 (huntingtin-associated protein 1). HAP1 is a neuronal protein that interacts with huntingtin and plays critical roles in intracellular trafficking, particularly in the transport of organelles and vesicles along microtubules. This protein is essential for neuronal function and has been implicated in neurodegenerative disorders, most notably Huntington's disease, where disrupted HAP1-huntingtin interactions contribute to cellular dysfunction. HAP1 also participates in receptor trafficking, synaptic function, and neuronal development, making it a significant target for understanding neurological pathophysiology.

Calpurbatug serves as the reference antibody for this biosimilar product, providing researchers with a reliable tool for investigating HAP1 expression, localization, and function in various experimental systems. This antibody is particularly valuable for studies examining neurodegenerative disease mechanisms, protein-protein interactions involving huntingtin, and intracellular transport processes in neuronal cells. It supports research into potential therapeutic strategies for Huntington's disease and related neurological conditions.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Target Background

Function

Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17).

Gene References into Functions

HAP1 is expressed in endocrine cells of the human gut. PMID: 27737633
data fully support that HAP1 is a GKAP, anchoring specifically to the cGMP-dependent protein kinase isoform Ibeta, and provide further evidence that also PKG spatiotemporal signaling is largely controlled by anchoring proteins PMID: 25653285
The -141 T > G polymorphism, but not the 1349 T > G polymorphism, may have protective effects for lung cancer. PMID: 25081373
HAP1 gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity PMID: 25446120
Overexpression of HAP1 reduced in vitro cell growth in breast cancer cell lines. PMID: 23440330
The results of this study found no association was found between the HAP1 T441M polymorphism and the age at onset of Huntington's disease . PMID: 22698993
The results of this study suggested that HAP1 co-localizes and associates with APP in physiological conditions of mouse and human brain. PMID: 22731248
WT HTT regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1). PMID: 21985783
HAP1/stigmoid body interacts with the normal ataxin-3 through Josephin domain PMID: 21386698
sortilin stabilizes the proBDNF.HAP1 complex PMID: 21357693
ADORA2A, but not HAP1 or OGG1, may have a role in age at onset in Huntington's disease PMID: 20512606
REVIEW: function of HAP1 PMID: 19262167
HAP1 may participate in axonal transport and activity-dependent release of pro-BDNF by interacting with the BDNF prodomain. PMID: 19996106
The combination of siRNA, the SB transposon, and an accurate transgenic mouse model may permit evaluation of this approach in preventing the pathogenesis associated with expression of mutant Htt. PMID: 15737634
Study provides genetic and functional evidence that the M441-HAP1 polymorphism modifies the age-at-onset of Huntington's disease . PMID: 18192679
REST/NRSF, dynactin p150(Glued), huntingtin, HAP1, and RILP form a complex involved in the translocation of REST/NRSF into the nucleus and HAP1 controls REST/NRSF cellular localization in neurons PMID: 18922795

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Subcellular Location

Cytoplasm. Cell projection, axon. Cell junction, synapse, presynapse. Cytoplasm, cytoskeleton. Cell projection, dendritic spine. Cell projection, dendrite. Lysosome. Endoplasmic reticulum. Mitochondrion. Nucleus. Cytoplasmic vesicle, autophagosome. Early endosome. Cell projection, growth cone. Cell projection, neuron projection. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.

Tissue Specificity

Predominantly expressed in brain. Selectively expressed in neurons.

Database Links

HGNC: 4812

OMIM: 600947

KEGG: hsa:9001

UniGene: Hs.158300

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Code	CSB-RA010129MB1HU
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HAP1 (Calpurbatug Biosimilar) Recombinant Monoclonal Antibody

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Target Background