HTRA1 (galegenimab Biosimilar) Recombinant Monoclonal Antibody

1. Nuclear downregulation of HtrA1 is associated with a better prognosis in women with high grade serous ovarian carcinoma. PMID: 30131069
2. Case Report: Novel compound heterozygous mutations in HTRA1 causing CARASIL in Chinese patient. PMID: 30068478
3. regulates odontoblastic differentiation of dental pulp cells through activation of the TGF-beta1/Smad signaling pathway PMID: 29580722
4. the aberrant expression of HTRA1 or HTRA4 may be involved in the onset of preeclampsia, and increased HTRA1 or HTRA4 expression may affect trophoblast functions. PMID: 30015931
5. HtrA1 contributes to the development of keloid lesions as matrix protease by remodelling keloid-specific ECM or cell surface molecules. PMID: 29695130
6. Studies indicate a significantly different high-temperature requirement factor A1 (HtrA1) expression in cancer and non-cancer tissue [Meta-analysis]. PMID: 29409460
7. HtrA1 overexpression further leads to impaired apical processes and decreased phagocytosis, an essential function for photoreceptor survival. PMID: 29269042
8. Results suggest that HTRA1 is involved in the pathogenesis of scars through regulating activation of latent TGF-beta1 in keloid fibroblasts. PMID: 29412803
9. the CADASIL-like family disease may be caused by heterozygous HTRA1 gene mutation, which leads to autosomal dominant hereditary cerebral small vessel disease. PMID: 29561953
10. Case Report/Review: novel missense mutation in HTRA1 associated with phenotype of CARASIL. PMID: 28628911
11. The rs11200638-rs2672598 joint genotype AA-CC conferred higher risk to exudative exudative age-related macular degeneration (AMD) than polypoidal choroidal vasculopathy (PCV). PMID: 27338780
12. a possible proteolytic processing mechanism of mutant TGFBIp by HTRA1 and peptides generated by mutant protein may form the beta-amyloid core of corneal aggregates in Corneal dystrophic patients. PMID: 28689406
13. HtrA1 Proteolysis of ApoE In Vitro Is Allele Selective PMID: 27379525
14. The observation of this study further supports the pathogenic role of the heterozygous HTRA1 mutations in familial cerebral small vessel disease. PMID: 28782182
15. These findings suggest that the variation in the risk for age-related macular degeneration associated with chromosome 10q26 is likely due to variation in HTRA1 expression. PMID: 28659708
16. HtrA1 role in the cisplatin resistance in colon cancer PMID: 28667026
17. HtrA1 could serve as a marker to identify ulcerative colitis of >10 year duration patients at high risk of developing colorectal cancer. PMID: 28586045
18. To our knowledge, this is the first time the association between rs11200638 and overall age-related macular degeneration has been reported in South America. PMID: 28846052
19. because the ARMS2/HTRA1 genes are positioned at a locus on chromosome 10q26 in a region with strong linkage disequilibrium, it is difficult to distinguish the functions of the individual genes. a review of recent epidemiological studies of Age-related macular degeneration(AMD) is offered. An argument for a definite correlation between the ARMS2 gene and AMD is presented PMID: 28583181
20. The expression of HtrA1 was strongly related to the T2 value, suggesting that HtrA1 plays an important role in the pathological process of intervertebral disc degeneration. PMID: 28432852
21. These results suggest that the initiation stage of polypoidal choroidal vasculopathy is mediated by proteolytic degradation of extracellular matrix proteins attributable to increased HTRA1 activity PMID: 28941979
22. The findings of the present study provide evidence that CFH gene variants and ARMS2/HTRA1 genes play a major role in the genetic susceptibility to AMD in a Greek population. These findings are of direct relevance for disease and help mapping the genetic chart of AMD. PMID: 26848857
23. The function of the binding between MIF and HTRA1 is to inhibit the proteolytic activity of HTRA1. PMID: 28726057
24. Results show that HTRA1 is epigenetically silenced in HCT116 colon carcinoma cells and during early stages of tumorigenesis in a mouse model of intestinal cancer. Downregulation of HTRA1 causes a multiple phenotypes that are hallmarks of cancer cells including increased proliferation of mouse embryonic fibroblasts, as well as chromosome and centrosome amplifications. PMID: 27388476
25. High HTRA1 expression is associated with cervical cell proliferation. PMID: 27809811
26. Data indicate HtrA serine peptidase 1 (HTRA1) involvement in Age-related macular degeneration (AMD) pathogenesis. PMID: 27841854
27. Variants in HTRA1 are not associated with age-related macular degeneration. PMID: 27879347
28. Results show the heterozygous missense mutations p.G283E, p.P285L, p.R302Q, and p.T319I in the HTRA1 gene in 8 patients with symptomatic cerebral small vessel disease; mutant HTRA1s observed in manifesting heterozygotes might result in an impaired HTRA1 activation cascade of HTRA1 or be unable to form stable trimers PMID: 27164673
29. FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation PMID: 28076935
30. correlation between TGFb1 and pSmad2 as well as between HtrA1 and TGFb1 and the very significant increase of Ki67 in stromal compartment of eutopic endometrium suggest a possible involvement of HtrA1 in the pathogenesis of endometriosis. PMID: 26708185
31. Two synonymous polymorphisms in exon 1 of the HTRA1 gene result in a protein with altered thermophoretic properties. PMID: 26310622
32. significant increase of serum HtrA1 in early-onset pre-eclampsia PMID: 26187609
33. a frameshift mutation in the HTRA1 gene detected in a CARASIL pedigree resulted in reduced HTRA1 protein and increased TGF-beta1 expression, which may cause severe CARASIL and peripheral small arterial disease PMID: 25772074
34. Human HTRA1 expression is enhanced by Age-related macular degeneration specific indel mutation in the promoter region of HTRA1 gene, and this enhanced HTRA1 may be concerned with induce retinal neovasucularization. PMID: 27125063
35. Results does not conclusively support HTRA1 role as a tumor suppressor but suggest its possible prognostic role in many human tumors. PMID: 26035313
36. Studies indicate that the high-risk allele of the 10q26 locus encompasses three genes, PLEKHA1, ARMS2, and HTRA1 with high linkage disequilibrium. PMID: 26427389
37. Low HtrA1 expression is associated with gastric cancer. PMID: 25761858
38. HtrA1 expression was closely related to EMT, which might be a potential mechanism underlying metastasis of HCC PMID: 26403966
39. Low HtrA1 expression is significantly related to breast cancer poor prognosis parameters, and HtrA1 loss in sentinel nodes is related to metastasis of non sentinel nodes. PMID: 25530301
40. It was concluded that high expression of HtrA1 could significantly reverse multidrug resistance of hepatoma cells by targeting XIAP. PMID: 25776486
41. The growth of choroidal neovascularization in AMD would be affected by 2 genes: MMP20, a newly confirmed gene expressed in the retina, and ARMS2/HTRA1, a well-known susceptibility gene for AMD. PMID: 26337002
42. HtrA1 appeared as an immunohistochemical marker to predict behaviour of the meningioma, mainly the recurrence PMID: 25687108
43. HtrA1 plays a positive role in human periodontal ligament cells osteogenic differentiation and may regulate this process by TGFB1. PMID: 25726184
44. In this study, we found that the interaction of ARMS2 and ARMS2/HTRA1 is significantly associated with nAMD, and the interaction of CFH and ARMS2 is pronounced in PCV development in Chinese population. PMID: 25771815
45. HtrA1 expression in plasma cells could be correlated with the destruction of pathological periodontal tissue. PMID: 24979214
46. Central but not peripheral drusen location was strongly associated with both [CFH HTRA1] and [CFH HTRA1]. Only [CFH HTRA1] was significantly associated with increased central drusen area. PMID: 25627090
47. heterozygous HTRA1 mutations are an important cause of familial small vessel disease PMID: 26063658
48. Silence of the HTRA1 gene was associated with significantly higher levels of TGF-beta1, BMP4, and BMP2 mRNA and reduction in the proliferation and migration of ARPE-19 cells. PMID: 25550099
49. Gene variants in CFH, ARMS2 and HTRA1 are related to an increased risk of age-related macular degeneration in a northern Chinese population. PMID: 24865190
50. alpha-1-antitrypsin as substrate of HTRA1 synthetic PMID: 25329061

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HGNC: 9476

OMIM: 600142

KEGG: hsa:5654

STRING: 9606.ENSP00000357980

UniGene: Hs.501280