Name: IL12&IL23 (Ustekinumab Biosimilar) Recombinant Monoclonal Antibody
Brand: CUSABIO
SKU: CSB-RA011587MB1HU

Product Details

Uniprot No.

P29459&P29460

Target Names

IL12&IL23

Alternative Names

CLMF antibody; CLMF p35 antibody; CLMF p40 antibody; CLMF1 antibody; CLMF2 antibody; Cytotoxic lymphocyte maturation factor 1, p35 antibody; Cytotoxic lymphocyte maturation factor 2 antibody; Cytotoxic lymphocyte maturation factor 35 kDa subunit antibody; Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody; IL 12A antibody; IL 2 subunit p40 antibody; IL-12 subunit p35 antibody; IL-12A antibody; IL-12B antibody; IL12 antibody; IL12, p35 subunit antibody; IL12, subunit p40 antibody; IL12A antibody; IL12A_HUMAN antibody; IL12B antibody; IL35 subunit antibody; Interleukin 12 alpha chain antibody; Interleukin 12 beta chain antibody; Interleukin 12 subunit beta antibody; Interleukin 12, p40 antibody; Interleukin 12A；natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35 antibody; Interleukin 12B；natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40 antibody; Interleukin 12B antibody; Interleukin-12 subunit alpha antibody; Natural killer cell stimulatory factor 1, 35 kD subunit antibody; natural killer cell stimulatory factor 2 antibody; Natural killer cell stimulatory factor, 40 kD subunit antibody; NF cell stimulatory factor chain 1 antibody; NFSK antibody; NK cell stimulatory factor chain 1 antibody; NK cell stimulatory factor chain 2 antibody; NKSF antibody; NKSF1 antibody; NKSF2 antibody; P35 antibody;CLMF antibody; CLMF p40 antibody; CLMF2 antibody; Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody; IL 12B antibody; IL-12 subunit p40 antibody; IL-12B antibody; IL12 p40 antibody; IL12B antibody; IL12B_HUMAN antibody; IMD28 antibody; IMD29 antibody; Interleukin 12 beta chain antibody; Interleukin 12 p40 antibody; Interleukin-12 subunit beta antibody; NK cell stimulatory factor chain 2 antibody; NKSF antibody; NKSF2 antibody

Species Reactivity

Human

Immunogen

Recombinant Human IL12&IL23 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

In stock

Description

This recombinant monoclonal antibody is a research-grade biosimilar of ustekinumab, targeting both interleukin-12 (IL-12) and interleukin-23 (IL-23) by binding to their shared p40 protein subunit. IL-12 is a heterodimeric cytokine composed of p35 and p40 subunits that promotes Th1 differentiation and interferon-gamma production, driving cell-mediated immunity against intracellular pathogens. IL-23, composed of p19 and p40 subunits, maintains and expands Th17 cell responses that produce pro-inflammatory cytokines including IL-17, IL-21, and IL-22. These two cytokines play central roles in autoimmune and inflammatory diseases, with IL-12 driving Th1-mediated responses and IL-23 sustaining pathogenic Th17-mediated inflammation in conditions such as psoriasis, inflammatory bowel disease, and psoriatic arthritis. Ustekinumab is a fully human IgG1κ monoclonal antibody that neutralizes both IL-12 and IL-23 by preventing their binding to the IL-12Rβ1 receptor, thereby blocking downstream Th1 and Th17 signaling pathways. This biosimilar provides researchers with a valuable tool for investigating IL-12/IL-23 biology, studying Th1 and Th17 differentiation mechanisms, and exploring dual-cytokine blockade strategies in preclinical models of immune-mediated inflammatory diseases.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Code	CSB-RA011587MB1HU
Size	US$9799
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IL12&IL23 (Ustekinumab Biosimilar) Recombinant Monoclonal Antibody

Product Details

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