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IL31RA (Nemolizumab Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA854162MB1HU
Size US$9799
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Product Details

Uniprot No.
Q8NI17
Target Names
IL31RA
Alternative Names
Anti-IL-31-receptor-monoclonal-antibody research-grade biosimilar; CD14152 research-grade biosimilar; CD-14152 research-grade biosimilar; CIM331 research-grade biosimilar; CIM-331 research-grade biosimilar; IL-31RA monoclonal antibody research-grade biosimilar; M5250 research-grade biosimilar; M5250B research-grade biosimilar; M5250E research-grade biosimilar; Mitchga research-grade biosimilar; Nemluvio research-grade biosimilar; Nemolizumab research-grade biosimilar; Nemolizumab (Genetical Recombination) research-grade biosimilar; Nemolizumab (genetical recombination) (JAN) research-grade biosimilar; Nemolizumab (INN) research-grade biosimilar; Nemolizumab-ilto research-grade biosimilar ;IL31RA antibody; CRL3 antibody; GPL antibody; UNQ6368/PRO21073/PRO21384 antibody; Interleukin-31 receptor subunit alpha antibody; IL-31 receptor subunit alpha antibody; IL-31R subunit alpha antibody; IL-31R-alpha antibody; IL-31RA antibody; Cytokine receptor-like 3 antibody; GLM-R antibody; hGLM-R antibody; Gp130-like monocyte receptor antibody; Gp130-like receptor antibody; ZcytoR17 antibody
Species Reactivity
Human
Immunogen
Recombinant Human IL31RA protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS，pH7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Notes
Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
Lead Time
3-4 weeks
Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to nemolizumab, targeting interleukin-31 receptor alpha (IL31RA). IL31RA forms a heterodimeric receptor complex with the oncostatin M receptor (OSMR) that binds IL-31, a cytokine primarily produced by activated T helper 2 cells. This signaling pathway plays a critical role in mediating pruritus (itch sensation) and inflammatory responses. IL31RA is predominantly expressed on sensory neurons, keratinocytes, and various immune cells, making it central to the pathophysiology of pruritic inflammatory skin conditions, particularly atopic dermatitis. Dysregulated IL-31 signaling has been implicated in chronic itch associated with allergic and inflammatory dermatoses.

Nemolizumab is a humanized IgG2 monoclonal antibody that selectively binds to IL31RA, blocking IL-31-mediated signaling and providing therapeutic relief from pruritus in atopic dermatitis patients. This biosimilar antibody serves as a valuable research tool for investigating IL-31/IL31RA pathway mechanisms, studying pruritus pathophysiology, evaluating inflammatory skin disease models, and exploring potential therapeutic interventions targeting itch-related disorders.

Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

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Target Background

Function
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro.
Gene References into Functions
  1. The first demonstration of the involvement of the IL-31/IL-31R axis in cancer came from studies in patients with mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T cell lymphoma. Tumor cells were shown to produce IL-31, whose serum levels correlated with pruritus intensity. PMID: 28408397
  2. The interleukin IL-31/IL-31receptor axis contributes to tumor growth in human follicular lymphoma. PMID: 25283844
  3. detected in keratinocytes and nerve fibers in the dermis of atopic dermatitis and in the neurons of normal dorsal root ganglia PMID: 24667097
  4. IL31RA is a functional receptor expressed by a small subpopulation of IL-31RA(+)/TRPV1(+)/TRPA1(+) neurons and is a critical neuroimmune link between TH2 cells and sensory nerves for the generation of T cell-mediated itch. PMID: 24373353
  5. IL-31 and IL-31RA are upregulated in patients with allergic rhinitis, and induce MUC5AC gene expression in human airway epithelial cells. PMID: 23392388
  6. IFN-gamma-induced IL-31RA upregulation in dermal microvascular endothelium is processed via JNK and PI3 kinase activation PMID: 20849534
  7. The identification of OSMR and IL31RA gene pathology provides an explanation of the high prevalence of primary cutaneous amyloidosis in Taiwan as well as new insight into disease pathophysiology. PMID: 19690585
  8. A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5. PMID: 11877449
  9. GPL is a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor PMID: 14504285
  10. the molecular mechanisms underlying GPL-mediated signal transduction PMID: 15194700
  11. IL-31 receptor alpha expression in epidermal keratinocytes is modulated by cell differentiation and interferon gamma PMID: 18580959
  12. ). Binding of IL-31 to its receptor activates Jak/STAT, PI3K/AKT and MAPK pathways.[review] PMID: 18926762

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Involvement in disease
Amyloidosis, primary localized cutaneous, 2 (PLCA2)
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane. Cell projection, axon.
Protein Families
Type I cytokine receptor family, Type 2 subfamily
Tissue Specificity
Expressed in CD14- and CD56-positive blood cells. Expressed in macrophages. Expressed in keratinocytes. Expressed in a subset of dorsal root ganglia neurons (at protein level). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, b
Database Links

HGNC: 18969

OMIM: 609510

KEGG: hsa:133396

STRING: 9606.ENSP00000415900

UniGene: Hs.55378

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