Function
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro.
Gene References into Functions
- The first demonstration of the involvement of the IL-31/IL-31R axis in cancer came from studies in patients with mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T cell lymphoma. Tumor cells were shown to produce IL-31, whose serum levels correlated with pruritus intensity. PMID: 28408397
- The interleukin IL-31/IL-31receptor axis contributes to tumor growth in human follicular lymphoma. PMID: 25283844
- detected in keratinocytes and nerve fibers in the dermis of atopic dermatitis and in the neurons of normal dorsal root ganglia PMID: 24667097
- IL31RA is a functional receptor expressed by a small subpopulation of IL-31RA(+)/TRPV1(+)/TRPA1(+) neurons and is a critical neuroimmune link between TH2 cells and sensory nerves for the generation of T cell-mediated itch. PMID: 24373353
- IL-31 and IL-31RA are upregulated in patients with allergic rhinitis, and induce MUC5AC gene expression in human airway epithelial cells. PMID: 23392388
- IFN-gamma-induced IL-31RA upregulation in dermal microvascular endothelium is processed via JNK and PI3 kinase activation PMID: 20849534
- The identification of OSMR and IL31RA gene pathology provides an explanation of the high prevalence of primary cutaneous amyloidosis in Taiwan as well as new insight into disease pathophysiology. PMID: 19690585
- A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5. PMID: 11877449
- GPL is a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor PMID: 14504285
- the molecular mechanisms underlying GPL-mediated signal transduction PMID: 15194700
- IL-31 receptor alpha expression in epidermal keratinocytes is modulated by cell differentiation and interferon gamma PMID: 18580959
- ). Binding of IL-31 to its receptor activates Jak/STAT, PI3K/AKT and MAPK pathways.[review] PMID: 18926762
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Involvement in disease
Amyloidosis, primary localized cutaneous, 2 (PLCA2)
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane. Cell projection, axon.
Protein Families
Type I cytokine receptor family, Type 2 subfamily
Tissue Specificity
Expressed in CD14- and CD56-positive blood cells. Expressed in macrophages. Expressed in keratinocytes. Expressed in a subset of dorsal root ganglia neurons (at protein level). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, b
