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ILDR2 (BAY-1905254 Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA751251MB2HU
Size US$9799
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Product Details

Uniprot No.
Q71H61
Target Names
ILDR2
Alternative Names
Bapotulimab research-grade biosimilar; CGEN-15001T program research-grade biosimilar; CGEN-15001T-targeted mAb research-grade biosimilar; CGEN-15001T-targeted monoclonal antibody research-grade biosimilar ;ILDR2 antibody; C1orf32 antibody; Immunoglobulin-like domain-containing receptor 2 antibody; Angulin-3 antibody
Species Reactivity
Human
Immunogen
Recombinant Human ILDR2 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS，pH7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Notes
Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
Lead Time
3-4 weeks
Description

This recombinant monoclonal antibody is designed as a research-grade biosimilar to BAY-1905254, targeting ILDR2 (Immunoglobulin-Like Domain Containing Receptor 2). ILDR2 is a transmembrane protein that plays a critical role in lipid metabolism and cellular lipid homeostasis, particularly in the regulation of triglyceride-rich lipoprotein uptake. This protein is expressed in various tissues including liver, intestine, and adipose tissue, where it influences metabolic processes. ILDR2 has emerged as a potential therapeutic target in metabolic disorders, including dyslipidemia and non-alcoholic fatty liver disease, as well as in certain cancers where aberrant lipid metabolism contributes to disease progression.

BAY-1905254 represents a research tool antibody developed for investigating ILDR2 function and its involvement in metabolic pathways. This biosimilar antibody provides researchers with a cost-effective alternative for studying ILDR2 expression patterns, protein interactions, and its role in lipid-related cellular processes. The antibody serves as a valuable reagent for exploring ILDR2 as a biomarker or therapeutic target in metabolic disease research and oncology studies.

Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Related Products

ILDR2 Antibodies

ILDR2 Proteins

Customer Reviews and Q&A

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Target Background

Function
May be involved in lipid homeostasis and ER stress pathways.
Gene References into Functions
  1. We demonstrated that ZNF70 interacts with ZFP64 and activates HES1 transcription by binding to the HES1 promoter. In addition, HES1 gene expression is increased in ILDR2-knockdown HepG2 cells, in which ZNF70 is translocated from the cytoplasm to the nucleus, suggesting that ZNF70 migration to the nucleus after dissociating from the ILDR2-ZNF70 complex activates HES1 transcription. These results support a novel link betwee PMID: 27353377
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  3. Observational study of gene-disease association. (HuGE Navigator) PMID: 19536175
  4. Observational study of gene-disease association. (HuGE Navigator) PMID: 19064610
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein Families
Immunoglobulin superfamily, LISCH7 family
Database Links

HGNC: 18131

KEGG: hsa:387597

UniGene: Hs.444835

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  Email: [email protected]
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Email
[email protected]
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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