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ILDR2 (Bapotulimab Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA751251MB1HU
Size US$9799
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Product Details

Uniprot No.
Q71H61
Target Names
ILDR2
Alternative Names
ILDR2; C1orf32Immunoglobulin-like domain-containing receptor 2
Species Reactivity
Human
Immunogen
Recombinant Human ILDR2 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS，pH7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Notes
Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
Lead Time
In stock
Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to Bapotulimab, targeting immunoglobulin-like domain-containing receptor 2 (ILDR2). ILDR2 is a cell surface protein that functions as a receptor involved in cellular adhesion and immune regulation processes. This protein has emerged as a significant target in oncology research, particularly in the context of tumor-associated macrophages and the immunosuppressive tumor microenvironment. ILDR2 expression has been implicated in various malignancies where it may contribute to immune evasion mechanisms and tumor progression.

Bapotulimab represents an investigational therapeutic antibody designed to modulate immune responses in the tumor microenvironment by targeting ILDR2-expressing cells. This biosimilar antibody provides researchers with a valuable tool for investigating ILDR2 biology, exploring its role in cancer immunology, and studying potential immunotherapeutic approaches. The antibody enables detailed examination of ILDR2-mediated signaling pathways, immune cell interactions, and its contribution to tumor immune escape mechanisms in preclinical models.

Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Related Products

ILDR2 Antibodies

ILDR2 Proteins

Customer Reviews and Q&A

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Target Background

Function
May be involved in lipid homeostasis and ER stress pathways.
Gene References into Functions
  1. We demonstrated that ZNF70 interacts with ZFP64 and activates HES1 transcription by binding to the HES1 promoter. In addition, HES1 gene expression is increased in ILDR2-knockdown HepG2 cells, in which ZNF70 is translocated from the cytoplasm to the nucleus, suggesting that ZNF70 migration to the nucleus after dissociating from the ILDR2-ZNF70 complex activates HES1 transcription. These results support a novel link betwee PMID: 27353377
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
  3. Observational study of gene-disease association. (HuGE Navigator) PMID: 19536175
  4. Observational study of gene-disease association. (HuGE Navigator) PMID: 19064610
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Protein Families
Immunoglobulin superfamily, LISCH7 family
Database Links

HGNC: 18131

KEGG: hsa:387597

UniGene: Hs.444835

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  Email: [email protected]
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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