INHBA (garetosmab Biosimilar) Recombinant Monoclonal Antibody

1. pro-activin A share features seen in the pro-TGF-beta1 and pro-BMP-9 structures. PMID: 27373274
2. Data suggest that activin A (INHBA) plays roles in inflammation, tissue repair, fibrosis, neoplastic activation of myofibroblasts, and leiomyoma development/growth. [REVIEW] PMID: 29100238
3. that high expression of INHBA was associated with poor response to therapy for de novo AML, and it can serve as an adverse prognostic factor for this malignancy. PMID: 28836868
4. Activin-A may induce fibrosis in NASH and alcoholic cirrhosis via activation of Kupffer cells to express pro-inflammatory molecules that promote HSC-dependent fibrogenesis and could be a target for future anti-fibrotic therapies. PMID: 29287776
5. Our study provided experimental and clinical evidence for the involvement of activin A and ALK4 in the pathophysiology of atrial fibrosis and atrial fibrillation PMID: 28639003
6. INHBA gene expression in gastric cancer tissue is considered a useful independent predictor of outcomes in patients with stage II/III gastric cancer who receive adjuvant chemotherapy with S-1. PMID: 28652421
7. Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle. (Review) PMID: 27756855
8. The present study was undertaken to evaluate the distribution of the FSHB -211 G/T in men with normal or abnormal sperm parameters from Southern Italy to assess its functional relevance on the serum levels of reproductive hormones and on sperm parameters in men. PMID: 28281143
9. binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-beta signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity. PMID: 26215835
10. analysis of a novel SMAD-independent pathway linking enhanced activin B signaling to reduced E-cadherin expression and increased migration in type II endometrial cancer PMID: 27223076
11. High INHBA expression is associated with lung adenocarcinoma. PMID: 26950277
12. activin A signaling has a role in melanoma growth and metastasis through immune evasion PMID: 28844941
13. These data provide evidence that eosinophils release activin A and that this function is enhanced when eosinophils are present in an allergen-induced inflammatory environment. PMID: 27001469
14. These results demonstrate that activin induces skin carcinogenesis via attraction and reprogramming of macrophages and identify novel activin targets involved in tumor formation. PMID: 27932444
15. our results defined a novel pathway in which dysregulation of the RUNX2/INHBA axis due to miR-376c downregulation fosters lymph node metastasis in head and neck squamous cell carcinoma PMID: 27760788
16. The activin-A to follistatin ratio may play a role in determining the clinical phenotype of preterm birth as preterm labor or preterm premature rupture of membranes. PMID: 27159193
17. A screen of a human protein library identified activin A as a potent regulator of follicular helper T cells cell differentiation. PMID: 27376469
18. Activin A is higher in patients with steatohepatitis than both lean and obese controls PMID: 27621190
19. INHBA expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
20. Activin A and preeclamptic serum upregulate ET-1, ICAM-1, and VCAM-1 in human umbilical vein endothelial cells, consistent with activin A contributing to the pathophysiology of preeclampsia. PMID: 27155341
21. Data show that dedifferentiated chondrocytes can be redifferentiated following treatment with the chimeric erythroid differentiation factor (activin A)/bone morphogenetic protein 2 (BMP2) ligand AB235. PMID: 26563344
22. Study shows that INHBA and FST are induced by seminal fluid in cervical tissues and thus, may contribute to regulation of the post-coital response in women. PMID: 26415587
23. Inhibin betaA is translationally regulated by TGFbeta via hnRNP E1. PMID: 26096938
24. we show a role for autocrine Activin signaling in the regulation of colony formation, cell migration and invasion in Barrett's tumorigenesis. PMID: 26447543
25. Our study uncovers the PITX2-induced expression of TGFB1/2/3 as well as INHBA genes (p < 0.01) followed by SMAD2/3-dependent TGF-b signalling pathway in ovarian cancer cells PMID: 26298390
26. changes in Follistatin levels during pregnancy contribute to the control of the activin A system PMID: 25565002
27. Overexpression of activin A in OSCCs, which is controlled by downregulation of miR-143/miR-145 cluster, regulates apoptosis, proliferation and invasiveness, and it is clinically correlated with lymph node metastasis and poor survival. PMID: 26317418
28. Activin A inhibited signaling by BMP-6 and BMP-9 by competing for type 2 receptors ACVR2A and ACVR2B. PMID: 26047946
29. Data suggest that activin A [plus bone morphogenic protein 4 (BMP4)] strongly stimulates germ cell differentiation potential of human embryonic stem cells; this stimulation appear to depend on gene expression regulation by activin A. PMID: 25634576
30. Increased serum level of activin A indicates its role in the pathogenesis of asthma, particularly in underweight and overweight patients. PMID: 25729977
31. Data suggest that an SNP in promoter region of ACVR2A (activin A receptor type IIA; rs1424954, the pre-eclampsia susceptibility allele) down-regulates signal transduction in trophoblasts in response to excess activin-A (as seen in pre-eclampsia). PMID: 25659497
32. able to restore glucose-stimulated insulin secretion in islets from type 2 diabetic donors PMID: 25833251
33. our study suggests that increased circulating concentrations of ActA may contribute to the development of cachexia in cancer patients. PMID: 25751105
34. Low activin-A expression was correlated with the occurrence, development, metastasis and malignant degree of lung adenocarcinoma. PMID: 25796148
35. Data suggest that activin A (dimer of INHBA), especially in lateral hypothalamus, plays role in neuronal sensing of free amino acids, appetite regulation, and neuronal plasticity. [REVIEW] PMID: 25200295
36. Activin-A and -B are abundantly expressed in mesothelioma tumor tissue. PMID: 25557874
37. INHBA overexpression implies adverse clinical outcomes for urothelial carcinoma, justifying it is a potential prognostic biomarker and a novel therapeutic target in UC PMID: 25488476
38. overexpression of INHBA in mesenchymal cells increases colony formation potential of epithelial cells, suggesting that it contributes to the dynamic reciprocity between breast mesenchymal and epithelial cells. PMID: 24916766
39. Activin A promoted chemotaxis, migration and proliferation of human periodontal ligament cells, and caused an increase in fibroblastic differentiation of these cells while down-regulating their osteoblastic differentiation. PMID: 24928494
40. High activin A signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer. PMID: 25449777
41. Activin A is an anti-lymphangiogenic factor, but because of its pleiotropic effects on cell mobility it appears not suitable as a pharmacological target. PMID: 25084052
42. Activin A, B, and AB have similar effects on steroidogenesis in human granulosa cells; in contrast, activin AC is not biologically active and does not act as a competitive antagonist. PMID: 25062451
43. expression of erythroid differentiation regulator 1 was negatively correlated with the malignant potential in various skin tumors. PMID: 24168163
44. Endothelial cells initiate a smooth muscle cell differentiation program in adjacent adipose stromal cells via induction activin A expression. PMID: 25114097
45. We identified an unreported germline mutation of the INHA gene encoding the alpha-subunit, the partner of the betaA-subunit. This mutation also alters the secreted activin/inhibin ratio, by disrupting both inhibin A and inhibin B biosynthesis. PMID: 24302632
46. Circulating activin A levels are associated with impaired myocardial glucose metabolism and high left ventricular mass/volume ratio in men with uncomplicated type 2 diabetes, reflecting a potential detrimental role in early human diabetic cardiomyopathy. PMID: 24134550
47. Follistatin, by its ability to neutralize the actions of activin A may be of value as an antifibrotic for radiation induced fibrosis. PMID: 24204752
48. the Activin/ALK4 pathway directly recruits PTP1B and stimulates its release from the endoplasmic reticulum through ALK4-mediated cleavage. PMID: 24139759
49. Activin A released from EAT-T2D inhibits insulin action via the induction of miR-143 in cardiomyocytes PMID: 23812417
50. Overexpression of the INHBA gene is considered a useful independent predictor of outcomes in patients with gastric cancer after curative surgery. PMID: 24778035

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HGNC: 6066

OMIM: 147290

KEGG: hsa:3624

STRING: 9606.ENSP00000242208

UniGene: Hs.28792