INHBA

INHBA encodes the Inhibin, Beta A subunit protein, also known as Activin A. This protein is a member of the transforming growth factor - β superfamily. It plays a crucial role in various biological processes such as cell growth, differentiation, and apoptosis through binding to activin receptors and activating downstream SMAD - mediated signaling pathways.
Activin A is implicated in multiple diseases including cancer, where it can promote tumor growth and metastasis. In reproductive disorders, it also shows abnormal regulation. Regarding drug development, there are ongoing efforts to design inhibitors targeting the activin signaling pathway to treat related diseases, aiming to block its over - activation in pathological conditions.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its ability to inhibit proliferation of MPC-11 cells. The ED50 for this effect is 0.9519-1.213 ng/mL.

Activity
Measured by its binding ability in a functional ELISA.Immobilized Human INHBA at 2 μg/ml can bind Human ACVR2A (CSB-MP001260HU1d9).The EC₅₀ is 74.75-84.73 ng/mL.

Activity
Measured by its binding ability in a functional ELISA.Immobilized Human INHBA at 2 μg/ml can bind Human ACVR2B (CSB-MP623829HUi9).The EC₅₀ is 45.93-52.42 ng/mL.

Activity
Measured by its binding ability in a functional ELISA.Immobilized Human INHBA at 2 μg/ml can bind Anti-INHBA recombinant antibody (CSB-RA011719MA1HU). The EC₅₀ is 10.28-12.68 ng/mL.

Recombinant Human Inhibin beta A chain (INHBA) (CSB-BP011719HU)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

INHBA Antibody (CSB-PA07589A0Rb)

Validated Data

Western Blot
Positive WB detected in: Hela whole cell lysate(30µg), HepG2 whole cell lysate(30µg), MCF-7 whole cell lysate(30µg)
All lanes: INHBA antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 48 kDa
Observed band size: 48 kDa
Exposure time: 120s

The following INHBA reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

INHBA Antibodies

INHBA Proteins

INHBA ELISA Kits

INHBA Antibodies

INHBA Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA011719GA01HU	INHBA Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA07589A0Rb	INHBA Antibody	Human	ELISA, WB
CSB-PA07589B0Rb	INHBA Antibody, HRP conjugated	Human	ELISA
CSB-PA07589C0Rb	INHBA Antibody, FITC conjugated	Human
CSB-PA07589D0Rb	INHBA Antibody, Biotin conjugated	Human	ELISA
CSB-PA005668	INHBA Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA903855	INHBA Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA055706	INHBA Antibody	Human,Mouse,Rat	ELISA,WB

INHBA Proteins

INHBA Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP011719RA CSB-EP011719RA CSB-BP011719RA CSB-MP011719RA CSB-EP011719RA-B	Recombinant Rat Inhibin beta A chain (Inhba)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

INHBA Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-YP011719SH CSB-EP011719SH CSB-BP011719SH CSB-MP011719SH CSB-EP011719SH-B	Recombinant Sheep Inhibin beta A chain (INHBA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

INHBA Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP011719CH CSB-EP011719CH CSB-BP011719CH CSB-MP011719CH CSB-EP011719CH-B	Recombinant Chicken Inhibin beta A chain (INHBA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

INHBA Proteins for Equus caballus (Horse)

Code	Product Name	Source
CSB-YP011719HO CSB-EP011719HO CSB-BP011719HO CSB-MP011719HO CSB-EP011719HO-B	Recombinant Horse Inhibin beta A chain (INHBA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

INHBA Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP011719PI CSB-EP011719PI CSB-BP011719PI CSB-MP011719PI CSB-EP011719PI-B	Recombinant Pig Inhibin beta A chain (INHBA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

INHBA Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP011719BO CSB-EP011719BO CSB-BP011719BO CSB-MP011719BO CSB-EP011719BO-B	Recombinant Bovine Inhibin beta A chain (INHBA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

INHBA Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP011719HU CSB-MP011719HU CSB-EP011719HU-B	Recombinant Human Inhibin beta A chain (INHBA)	Yeast Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP011719HU	Recombinant Human Inhibin beta A chain (INHBA)	E.coli
CSB-AP004011HU	Recombinant Human Inhibin beta A chain (INHBA) (Active)	Mammalian cell
CSB-BP011719HU	Recombinant Human Inhibin beta A chain (INHBA)	Baculovirus
CSB-MP011719HU-WD	Recombinant Human Inhibin beta A chain (INHBA) (Active)	Mammalian cell
CSB-EP011719HUc7	Recombinant Human Inhibin beta A chain (INHBA)	E.coli
CSB-MP011719HU1	Recombinant Human Inhibin beta A chain (INHBA)	Mammalian cell
CSB-MP011719HU1b0	Recombinant Human Inhibin beta A chain (INHBA) (Active)	Mammalian cell

INHBA Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-YP751056CA CSB-EP751056CA CSB-BP751056CA CSB-MP751056CA CSB-EP751056CA-B	Recombinant Cat Inhibin beta A chain (INHBA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

INHBA ELISA Kit

INHBA ELISA Kit for Bos taurus (Bovine)

Code	Product Name	Sample Types	Sensitivity
CSB-EL011719BO	Bovine Inhibin beta A chain(INHBA) ELISA kit	serum, plasma, tissue homogenates	15 pg/mL

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INHBA

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