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MICA/B (CLN-619 Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA56059MB1HU
Size US$9799
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Product Details

Uniprot No.
J9TPG6
Target Names
MICA/B
Alternative Names
MHC Class I chain-related protein; MHC class I polypeptide-related sequence A; MICA; CLN-619
Species Reactivity
Human
Immunogen
Recombinant Human MICA/B protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS，pH7.4
Form
Liquid
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Notes
Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.
Lead Time
In stock
Description

This recombinant monoclonal antibody is a research-grade biosimilar of CLN-619, targeting both MICA (MHC class I chain-related protein A) and MICB (MHC class I chain-related protein B). MICA and MICB are stress-induced surface glycoproteins that function as ligands for the NKG2D receptor on natural killer cells and cytotoxic T cells, serving as danger signals for immune-mediated elimination of transformed or damaged cells. These proteins are upregulated on many human cancers following cellular stress, but tumors evade immune surveillance by proteolytically shedding MICA/B from their surface, releasing soluble forms that correlate with tumor progression and poor prognosis. CLN-619 is a humanized IgG1 antibody that binds to the alpha-3 domain of MICA/B, preventing proteolytic shedding and restoring cell surface expression. This mechanism re-establishes NKG2D-mediated tumor recognition while simultaneously engaging CD16A Fc receptors on immune effector cells, promoting tumor lysis through dual pathways. This biosimilar enables researchers to investigate MICA/B biology, NK cell-mediated tumor immunity, and therapeutic strategies targeting immune evasion mechanisms in preclinical cancer models.

Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Related Products

MICA/B Antibodies

MICA/B Proteins

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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