Name: PTPRS (KK-4277 Biosimilar) Recombinant Monoclonal Antibody
Brand: CUSABIO
SKU: CSB-RA613393MB1HU

Product Details

Uniprot No.

Q13332

Target Names

PTPRS

Alternative Names

KK4277 research-grade biosimilar; KK 4277 research-grade biosimilar ;PTPRS antibody; Receptor-type tyrosine-protein phosphatase S antibody; R-PTP-S antibody; EC 3.1.3.48 antibody; Receptor-type tyrosine-protein phosphatase sigma antibody; R-PTP-sigma antibody

Species Reactivity

Human

Immunogen

Recombinant Human PTPRS protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Description

This recombinant monoclonal antibody is designed as a research-grade biosimilar to KK-4277, targeting PTPRS (Protein Tyrosine Phosphatase Receptor Type S), also known as PTPσ. PTPRS is a member of the receptor-type protein tyrosine phosphatase family that plays critical roles in regulating cellular signaling pathways, particularly in neuronal development and axon regeneration. This transmembrane receptor acts as a key regulator of nerve cell growth and repair by controlling phosphorylation states of intracellular substrates. PTPRS has been implicated in various neurological conditions, including spinal cord injury recovery, peripheral nerve regeneration, and neurodevelopmental disorders. Additionally, aberrant PTPRS expression has been associated with certain cancers where it may influence tumor progression and metastasis.

The reference antibody KK-4277 has been utilized in research investigating PTPRS function and localization in neural tissues and other cellular contexts. This biosimilar provides researchers with a valuable tool for exploring PTPRS-mediated signaling mechanisms, studying its role in axon guidance and synaptic plasticity, and investigating potential therapeutic interventions targeting this phosphatase in regenerative medicine and oncology research.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Target Background

Function

Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.

Gene References into Functions

Study identified several CpG sites and specifically several CpGs in the PTPRS and PER3 genes differentially methylated between obese and non-obese children, suggesting a role for DNA methylation concerning development of childhood obesity. PMID: 28614626
interaction of receptor type of protein tyrosine phosphatase sigma (RPTPsigma) with a glycosaminoglycan library PMID: 29420785
Receptor protein tyrosine phosphatase sigma (RPTPsigma) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis. PMID: 25385546
Data demonstrate that synoviocytes are regulated by an RPTPsigma-dependent proteoglycan switch in vivo, which can be targeted for rheumatoid arthritis therapy. PMID: 25995222
represents an evolutionarily conserved pDC-specific inhibitory receptor, and is required to prevent spontaneous IFN production and immune-mediated intestinal inflammation PMID: 26231120
crystallographic analyses of a shared HSPG-CSPG binding site reveal a conformational plasticity that can accommodate diverse glycosaminoglycans with comparable affinities; HS and analogs induced RPTPsigma ectodomain oligomerization which was inhibited by CS PMID: 21454754
Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma. PMID: 22027896
Intragenic microdeletions of the EGFR phosphatase PTPRS were found frequently (26%) in head and neck cancers, identifying this gene as a target of 19p13 loss. PMID: 22065749
Transgenic zebrafish carrying a promoter-driven expression vector reveal the increased density of olfactory sensory neuron-specific cell synapses. PMID: 21812780
Data show that PTPsigma localizes to PtdIns3P-positive membranes in cells, and this vesicular localization is enhanced during autophagy. PMID: 21303930
The receptor protein tyrosine phosphatase sigma (RPTPsigma) has now been identified as a receptor for inhibitory chondroitin sulfate proteoglycans. PMID: 20179269
Transient overexpression of the short splice variant 3 of RPTPR Sigma conferred alpha-LTX induced secretion to hamster insulinoma (HIT-15) cells. In contrast, the long splice variant 2 was inactive in secretion or in a single cell assay. PMID: 16552719
Three SNPs that flank exon 8 are associated with ulcerative colitis. The presence of these SNPs is associated with novel splicing that removes the third immunoglobulin-like domain (exon 9) from the extracellular portion of PTPsigma. PMID: 17614280
SNPs rs1143699, rs4807015, and rs1978237 confer an increased risk of developing type 2 diabetes mellitus. PMID: 17893260
In colorectal tumors, microsatellite repeats mutation rates are higher than the mean mutation frequency PMID: 19000305

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Perikaryon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density. Cell projection, neuron projection. Cell projection, growth cone.

Protein Families

Protein-tyrosine phosphatase family, Receptor class 2A subfamily

Tissue Specificity

Detected in peripheral blood plasmacytoid dendritic cells (at protein level). Detected in all tissues tested except for placenta and liver. Detected in peripheral blood plasmacytoid dendritic cells.

Database Links

HGNC: 9681

OMIM: 601576

KEGG: hsa:5802

STRING: 9606.ENSP00000349932

UniGene: Hs.744928

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Code	CSB-RA613393MB1HU
Size	US$9799
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PTPRS (KK-4277 Biosimilar) Recombinant Monoclonal Antibody

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Target Background