Name: PVRIG (GSK-4381562 Biosimilar) Recombinant Monoclonal Antibody
Brand: CUSABIO
SKU: CSB-RA721905MB2HU

Product Details

Uniprot No.

Q6DKI7

Target Names

PVRIG

Alternative Names

GSK4381562 research-grade biosimilar; GSK 4381562 research-grade biosimilar; GSK4381562A research-grade biosimilar; GSK562 research-grade biosimilar; SRF813 research-grade biosimilar; SRF-813 research-grade biosimilar ;PVRIG antibody; C7orf15 antibody; Transmembrane protein PVRIG antibody; CD112 receptor antibody; CD112R antibody; Poliovirus receptor-related immunoglobulin domain-containing protein antibody

Species Reactivity

Human

Immunogen

Recombinant Human PVRIG protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Description

This recombinant monoclonal antibody is a research-grade biosimilar to GSK-4381562, designed to target PVRIG (PVR-related immunoglobulin domain-containing protein), also known as CD112R. PVRIG functions as an inhibitory immune checkpoint receptor expressed on T cells and NK cells that binds to its ligand PVRL2 (CD112), delivering suppressive signals that dampen anti-tumor immune responses. By engaging PVRL2, PVRIG inhibits T cell activation and cytotoxic function, contributing to immune evasion mechanisms exploited by tumors. PVRIG is particularly relevant in cancer immunology research, where it represents an emerging therapeutic target for overcoming resistance to existing checkpoint inhibitors.

GSK-4381562 is a clinical-stage antibody developed to block the PVRIG-PVRL2 interaction, thereby enhancing T cell-mediated anti-tumor immunity. This biosimilar provides researchers with a valuable tool for investigating PVRIG biology, studying immune checkpoint mechanisms, and exploring combination immunotherapy strategies in preclinical models. It enables examination of PVRIG's role in tumor microenvironments and its potential as a therapeutic target across various malignancies.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Target Background

Function

Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.

Gene References into Functions

Blockade of TIGIT or CD112R, separately or together, enhances trastuzumab-triggered antitumor response by human NK cells. PMID: 28623459
Describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor-mediated signals. PMID: 26755705

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Tissue Specificity

Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-

Database Links

HGNC: 32190

OMIM: 617012

KEGG: hsa:79037

STRING: 9606.ENSP00000316675

UniGene: Hs.729356

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Code	CSB-RA721905MB2HU
Size	US$9799
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PVRIG (GSK-4381562 Biosimilar) Recombinant Monoclonal Antibody

Product Details

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Target Background