PVRIG, also known as CD112R, is an immunosuppressive receptor primarily expressed on NK cells and T cells. It possesses a unique structure that includes a transmembrane region, an intracellular domain, and an extracellular immunoglobulin variable-like domain, enabling it to recognize and bind to its ligand, PVRL2, thereby regulating immune function. When PVRIG binds to PVRL2, it suppresses immune activation and blocks stimulatory signal transmission through competitive binding with CD226. In the tumor microenvironment, tumor cells express high levels of PVRL2 to bind with PVRIG on immune cells, transmitting inhibitory signals that facilitate immune evasion and tumor progression. As for signaling, PVRIG engagement with its ligand triggers a cascade of intracellular signaling events, leading to the suppression of immune cell function. Therefore, a thorough investigation of PVRIG's structure, function, and signaling pathways holds significant promise for understanding immune suppression mechanisms and developing novel immunotherapy strategies.
Recombinant Human Transmembrane protein PVRIG (PVRIG)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The following PVRIG reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
PVRIG Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA721905LA01HU | PVRIG Antibody |
Human | ELISA, WB, IF |
CSB-PA721905LB01HU | PVRIG Antibody, HRP conjugated |
Human | ELISA |
CSB-PA721905LC01HU | PVRIG Antibody, FITC conjugated |
Human | |
CSB-PA721905LD01HU | PVRIG Antibody, Biotin conjugated |
Human | ELISA |
PVRIG Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF721905HU | Recombinant Human Transmembrane protein PVRIG (PVRIG) |
in vitro E.coli expression system |
CSB-YP721905HU1 CSB-EP721905HU1 CSB-BP721905HU1 CSB-MP721905HU1 CSB-EP721905HU1-B |
Recombinant Human Transmembrane protein PVRIG (PVRIG), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP721905HU | Recombinant Human Transmembrane protein PVRIG (PVRIG)-VLPs |
Mammalian cell |