ROR2 (ozuriftamab Biosimilar) Recombinant Monoclonal Antibody

1. Here, we show that Wnt/planar cell polarity (PCP) autocrine signaling controls the emergence of cytonemes, and that cytonemes subsequently control paracrine Wnt/beta-catenin signal activation. Upon binding of the Wnt family member Wnt8a, the receptor tyrosine kinase Ror2 becomes activated. PMID: 30060804
2. Wnt5a-Ror2 signaling enhanced tongue SCC cell aggressiveness and promoted production of MMP-2 following DeltaNp63beta-mediated EMT PMID: 28559016
3. In squamous/adenosquamous carcinoma and adenocarcinoma of the gallbladder positive ROR2 or WNT5a expression is generally associated with a poor prognosis. PMID: 28465645
4. Wnt5a suppressed osteoblastic differentiation through Ror2/JNK signaling in periodontal ligament stem cell-like cells. PMID: 28681925
5. Data show that receptor tyrosine kinase-like orphan receptor 2 (ROR2) is epigenetically silenced by promoter hypermethylation in colorectal cancer cell lines and in early stages of colorectal neoplasia tissue. PMID: 27440078
6. WNT5A and ROR2 are induced by inflammatory mediators through NF-kB and STAT3 transcription factors, and are involved in the migration of human ovarian cancer cell line SKOV-3. PMID: 28536612
7. On these bases, we identified that miR-208b targets receptor tyrosine kinase-like orphan receptor 2 gene by which miR-208b can regulate the development of osteosarcoma. PMID: 28618961
8. Our findings suggest that receptor tyrosine kinase-like orphan receptor 2 may be an important regulator of epithelial-mesenchymal transition, primarily regulated the non-canonical Wnt signaling pathway in ovarian cancer cells, and may display a promising therapeutic target for ovarian cancer. PMID: 28475014
9. Knockdown of Ror2 expression in renal cell carcinoma cells significantly reduced cell proliferation and induced apoptosis. PMID: 28277191
10. found no association between ROR2 staining and poor patient survival PMID: 27631337
11. Data show that CD13 anntigen and receptor tyrosine kinase-like orphan receptor 2 (ROR2) identify a cardiac lineage precursor pool that is capable of successful engraftment into the porcine heart. PMID: 26771355
12. ROR2 gene mutations are associated with autosomal recessive robinow syndrome. PMID: 26284319
13. results corroborated previous findings of Ryk-mediated Wnt5a effect, and suggested a role for Ror2 in the Wnt5a machinery in glioblastoma PMID: 26596412
14. Wnt5a-Ror2 signaling enhances expression and secretion of CXCL16 in mesenchymal stem cells thereby activating CXCR6 expressed on tumor cells to promote proliferation. PMID: 26708384
15. We present strong evidence that ROR2 could be used as an indicator of poor prognosis and could represent a novel therapeutic target for PDAC. PMID: 26259918
16. Findings suggest that high receptor tyrosine kinase-like orphan receptor (ROR) 2 or proto-oncogene protein Wnt-5A (Wnt5a) expression is associated with poor prognosis in non-small cell lung cancer (NSCLC). PMID: 26305508
17. These data suggest a mechanism where human cytomegalovirus alters the expression of the Wnt receptor ROR2 to alter Wnt5a-mediated signaling and inhibit trophoblast motility PMID: 26559837
18. Positive ROR2 and FRAT1 expression is associated with the progression and poor prognosis of chondrosarcoma. PMID: 25387569
19. These results indicate that ROR2 is significantly correlated with cancer progression and poor prognosis in cervical cancer PMID: 25755786
20. Mutations in key regions of the kinase domain of Ror2 resulted in the abrogation of increased tumor growth, cell migration, and cell invasion observed with expression of wild-type Ror2. PMID: 25542006
21. High expression of the novel Wnt receptor ROR2 is associated with breast cancer. PMID: 25209439
22. These results suggest that ROR2 expression is correlated with malignant attributes of CRC and may serve as an indicator for poor prognosis in patients with CRC. PMID: 25301559
23. this paper reports the findings on three families with recessive Robinow syndrome which were identified in India. Three mutations in ROR2 gene, two novels and one previously known mutation were observed in these patients PMID: 24932600
24. report a three-generation Chinese family with dominant inheritance of the BDB1 limb phenotype. Sequence analysis identified a novel heterozygous base deletion (c.1396-1398delAA) in the gene ROR2 in all affected family members PMID: 24954533
25. ROR2 is an epigenetically inactivated tumor suppressor gene that antagonizes both beta-catenin and AKT signaling in multiple various carcinomas. PMID: 24158497
26. a new role for Ror2 in conveying a tonic signal to stabilize soluble beta-catenin and create a poised state of enhanced responsiveness to Wnt3a exogenous signals in RCC. PMID: 23893409
27. This study demonstrated the first attempt to identify Wnt5a and Ror2 as additional mechanisms contributing to dysregulation of the non-canonical WNT signaling pathway in medulloblastoma. Ror2 may play a role as an oncosuppressor in medulloblastoma. PMID: 23278988
28. DEX induces the upregulation of noncanonical Wnt ligand Wnt5a. Recombinant WNT5a protein induces CLAN formation through the noncanonical Wnt receptor ROR2/RhoA/ROCK signaling axis. PMID: 23963164
29. Sequence analysis of the gene ROR2 indicated a nonsense mutation (c.2278C>T, p.Q760X) in exon 9 in all brachydactyly type B affected individuals of the family. PMID: 23238279
30. ROR2 expression was not seen in any of the hematological malignancies studied. PMID: 22988987
31. review will explore the dual role of ROR2 in tumorigenesis and provide an up to date analysis of current literature in this rapidly expanding field PMID: 23233346
32. Our results do not support the relevance of ROR2/Wnt5a as biomarkers in stage 1 pure seminomas PMID: 23469623
33. High ROR2 expression is involved in the pathophysiology of Multiple myeloma-induced bone disease. PMID: 22781592
34. The unusual Asp-Leu-Gly motif in Ror2 is displaced compared with other inactive kinases, allowing the activation loop to interact directly with the tyrosine kinase domains. PMID: 22992069
35. Molecular analysis of the ROR2 gene in a Lebanese family with a mild form of recessive Robinow syndrome revealed the presence of a previously undescribed missense mutation: p.R272C (c.814C>T), in the cysteine-rich domain of the protein. PMID: 22178368
36. The present study provides evidence of the significant association between ROR2 variants and the OPG/RANKL ratio in human plasma and also suggests ROR2 association with hand osteoarthritis. PMID: 22057548
37. Results provided evidence of linkage and association between the ROR2 gene and a gene controlling risk to non-syndromic cleft palate. PMID: 22490406
38. Results show that ROR2 is a useful prognostic indicator in the clinical management of these soft-tissue sarcomas and may represent a novel therapeutic target. PMID: 22294416
39. WNT-5a and ROR2 were more highly expressed in more severe disease states, and therefore may play a coordinated role in the occurrence and progression of osteosarcoma PMID: 22293903
40. Data suggest that Wnt5a and Ror2 may serve as tumor suppressor genes in the development of hepatocellular carcinoma, and may serve as clinicopathologic biomarkers for prognosis in HCC patients. PMID: 22493546
41. Wnt5a-Ror2 signaling might also be required for expression of MMP-13 gene during the development of the cartilaginous tissue. PMID: 22128168
42. We report two mentally retarded female siblings and their cognitively normal father, all carrying a similar 5.3 Mb microdeletion at 9q22.2q22.32, involving 30 genes including the ROR2 gene and and SYK gene. PMID: 21693067
43. 2265C>A mutation in ROR2 gene is associated with Brachydactyly type B1 in Chinese family. PMID: 21377971
44. Results suggest that Wnt5a plays the role of a tumor suppressor in leukemogenesis through the Wnt5a/Ror2 noncanonical signaling pathway that inhibits Wnt canonical signaling. PMID: 21069266
45. Results show expression of Wnt5a and Ror2 is induced during Snail-mediated epithelial-mesenchymal transition or malignant progression of cancer cells and that activated Wnt5a-Ror2 signaling confers highly motile and invasive properties on cancer cells. PMID: 21342370
46. data show the importance of epigenetic alterations of ROR2 in colon cancer, highlighting the close interconnection between canonical and non-canonical Wnt signalling pathways in this type of tumour PMID: 20591152
47. a unique regulation pattern for Ror2 in the VHL-HIF axis that has the potential to be applied to other cancer etiologies. PMID: 20185829
48. Data showed a correlation between the severity of BDB1, the location of the mutation, and the amount of membrane-associated ROR2. PMID: 19640924
49. The deletion represents the second ROR2 mutation associated with a autosomal dominant brachydactyly type B1-syndactyly phenotype. PMID: 19461659
50. Data show that ROR2 knockdown results in a decrease in signaling downstream of Wnt5A. PMID: 19802008

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HGNC: 10257

OMIM: 113000

KEGG: hsa:4920

STRING: 9606.ENSP00000364860

UniGene: Hs.644776