Name: SIGLEC10 (ONC-841 Biosimilar) Recombinant Monoclonal Antibody
Brand: CUSABIO
SKU: CSB-RA842706MB1HU

Product Details

Uniprot No.

Q96LC7

Target Names

SIGLEC10

Alternative Names

ONC841 research-grade biosimilar; ONC 841 research-grade biosimilar; ONC-841 research-grade biosimilar ;SIGLEC10 antibody; SLG2 antibody; UNQ477/PRO940 antibody; Sialic acid-binding Ig-like lectin 10 antibody; Siglec-10 antibody; Siglec-like protein 2 antibody

Species Reactivity

Human

Immunogen

Recombinant Human SIGLEC10 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

0.01M PBS，pH7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Notes

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity > 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Lead Time

3-4 weeks

Description

This recombinant monoclonal antibody is developed as a research-grade biosimilar to ONC-841, targeting SIGLEC10 (Sialic acid-binding Ig-like lectin 10), an immunoregulatory receptor expressed predominantly on immune cells including macrophages, dendritic cells, and B cells. SIGLEC10 functions as an immune checkpoint by recognizing sialic acid-containing glycans on cell surfaces and delivering inhibitory signals through its immunoreceptor tyrosine-based inhibitory motifs (ITIMs). This receptor plays a critical role in maintaining immune homeostasis and self-tolerance, while its dysregulation has been implicated in cancer immune evasion, as tumor cells exploit SIGLEC10 signaling to suppress anti-tumor immune responses. Elevated SIGLEC10 expression has been associated with various malignancies and represents an emerging therapeutic target for cancer immunotherapy.

The reference antibody ONC-841 has been investigated as a potential immune checkpoint inhibitor designed to block SIGLEC10-mediated immunosuppression and enhance anti-tumor immunity. This biosimilar provides researchers with a valuable tool for investigating SIGLEC10 biology, exploring immune checkpoint mechanisms, and conducting preclinical studies in oncology and immunology research.

Usage

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

Related Products

Target Background

Function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1. In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. In association with CD24 may regulate the immune repsonse of natural killer (NK) cells. Plays a role in the control of autoimmunity. During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification.

Gene References into Functions

soluble CD52 exerts a concerted immunosuppressive effect by first sequestering HMGB1 to nullify its proinflammatory Box B, followed by binding to the inhibitory Siglec-10 receptor, triggering recruitment of SHP1 to the intracellular immunoreceptor tyrosine-based inhibitory motif of Siglec-10 and its interaction with the TCR. PMID: 29997173
Siglec-10 is associated with decreased survival and impaired NK cell function in human hepatocellular carcinoma (HCC). PMID: 25450598
Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium PMID: 19861682

Subcellular Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; [Isoform 5]: Secreted.

Protein Families

Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family

Tissue Specificity

Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 a

Database Links

HGNC: 15620

OMIM: 606091

KEGG: hsa:89790

STRING: 9606.ENSP00000345243

UniGene: Hs.284813

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Code	CSB-RA842706MB1HU
Size	US$9799
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SIGLEC10 (ONC-841 Biosimilar) Recombinant Monoclonal Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background