SIGLEC10 stands out as a unique member within the siglecs superfamily, possessing a structure resembling adhesion molecules that facilitate sialic acid-dependent cell binding. Functioning as an inhibitory receptor, SIGLEC10 plays a pivotal role in immune responses by regulating them through the induction of tyrosine phosphorylation, recruitment of phosphatases, and negative modulation of B-cell antigen receptor signaling. Furthermore, SIGLEC10 collaborates with CD24 to modulate NK cell responses and autoimmunity, while suppressing cross-presentation by dendritic cells. Additionally, SIGLEC10 is involved in lymphocyte adhesion to endothelial cells, altering the inflammatory microenvironment. Currently, SIGLEC10 has emerged as a crucial target for medical research and drug development, with potential applications including the treatment of non-small cell lung cancer, ovarian cancer, pancreatic cancer, and colorectal cancer.
Recombinant Human Sialic acid-binding Ig-like lectin 10 (SIGLEC10), partial
Source: Yeast
Source: E.coli
Source: Baculovirus
Source: Mammalian cell
Source: In Vivo Biotinylation in E.coli
The following SIGLEC10 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SIGLEC10 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA235687 | SIGLEC10 Antibody |
Human | ELISA,IHC |
CSB-PA842706LA01HU | SIGLEC10 Antibody |
Human | ELISA, IHC, IF |
CSB-PA842706LB01HU | SIGLEC10 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA842706LC01HU | SIGLEC10 Antibody, FITC conjugated |
Human | |
CSB-PA842706LD01HU | SIGLEC10 Antibody, Biotin conjugated |
Human | ELISA |
SIGLEC10 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP842706HU CSB-EP842706HU CSB-BP842706HU CSB-MP842706HU CSB-EP842706HU-B |
Recombinant Human Sialic acid-binding Ig-like lectin 10 (SIGLEC10), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |