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SLITRK6 (Sirtratumab Biosimilar) Recombinant Monoclonal Antibody

Datasheet
Code CSB-RA867155MA2HU
Size US$199
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Product Details

Uniprot No.
Q9H5Y7
Target Names
SLITRK6
Alternative Names
4832410J21Rik antibody; DFNMYP antibody; MGC119595 antibody; MGC119596 antibody; MGC119597 antibody; OTTHUMP00000066012 antibody; SLIK6_HUMAN antibody; SLIT and NTRK like family member 6 antibody; SLIT and NTRK like protein 6 antibody; SLIT and NTRK-like protein 6 antibody; Slit and trk like 6 antibody; Slit and trk like gene 6 antibody; SLITRK 6 antibody; Slitrk6 antibody; Sirtratumab
Species Reactivity
Human
Immunogen
Recombinant Human SLITRK6 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Isotype
Human IgG1 kappa
Purification Method
Affinity-chromatography
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, FACS
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
Recommended Service
High throughput recombinant antibody production to help select the right therapeutic antibodies at competitive prices.

Related Products

SLITRK6 Antibodies

SLITRK6 Proteins

Customer Reviews and Q&A

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Target Background

Function
Regulator of neurite outgrowth required for normal hearing and vision.
Gene References into Functions
  1. Analysis of two exons of SLITRK6 gene in a Moroccan family identify a novel single deleterious mutation c.696delG, p.Trp232Cysfs*10 at homozygous state in the exon 2 of the SLITRK6, a gene reported to cause deafness and myopia in various populations. PMID: 29551497
  2. Human cytomegalovirus downregulates SLITRK6 expression through IE2. PMID: 27530937
  3. SLITRK6 gene nonsense mutation is associated with progressive auditory neuropathy in humans. PMID: 23946138
  4. SLITRK6 plays a crucial role in the development of normal hearing as well as vision in humans and in mice and that its disruption leads to a syndrome characterized by severe myopia and deafness. PMID: 23543054
Involvement in disease
Deafness and myopia (DFNMYP)
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
SLITRK family
Tissue Specificity
In adult brain, highly expressed in putamen with no expression in cerebral cortex. Expressed in adult and fetal lung and fetal liver. Also expressed at high levels in some brain tumors including medulloblastomas and primitive neuroectodermal tumors.
Database Links

HGNC: 23503

OMIM: 221200

KEGG: hsa:84189

STRING: 9606.ENSP00000383143

UniGene: Hs.525105

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  Email: [email protected]
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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