ADAMTS10 Antibody

Datasheet

Code	CSB-PA798156
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA798156(ADAMTS10 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA798156(ADAMTS10 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9H324

Target Names

ADAMTS10

Alternative Names

A disintegrin and metalloproteinase with thrombospondin motifs 10 antibody; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif; 10 antibody; A disintegrin-like and metallopeptidase with thrombospondin type 1 motif; 10 antibody; ADAM metallopeptidase with thrombospondin type 1 motif 10 antibody; ADAM TS10 antibody; ADAM-TS 10 antibody; ADAM-TS10 antibody; ADAMTS-10 antibody; Adamts10 antibody; ATS10_HUMAN antibody; EC 3.4.24 antibody; WMS antibody; WMS1 antibody; zinc metalloendopeptidase antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human ADAMTS10

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.

Gene References into Functions

Using siRNA, over-expression and mutagenesis, it was found ADAMTS6 inhibits and ADAMTS10 is required for focal adhesions, epithelial cell-cell junction formation, and microfibril deposition. PMID: 27779234
These findings support the Gly661Arg mutation of ADAMTS10 as the likely cause of POAG in beagles. PMID: 23422823
ADAMTS10 participates in microfibril biogenesis rather than in fibrillin-1 turnover PMID: 21402694
ADAMTS10 is a functional metalloprotease as demonstrated by cleavage of alpha2-macroglobulin PMID: 15355968
Expression in human colonic cell lines. PMID: 15358598
ADAMTS10 plays a major role in growth and in skin, lens, and heart development in humans. PMID: 15368195
infer that folding of the complex C-terminal ancillary domain is the rate-limiting step in biosynthesis of ADAMTS10, and that it (but not catalytic domain) is sensitive to subtle changes in efficiency of signal peptide cleavage. PMID: 18567016
Mutations in ADAMTS10 gene is not responsible for microspherophakia. PMID: 19696795
Homozygous mutation in ADAMTS10 causes lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. PMID: 19836009

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Involvement in disease

Weill-Marchesani syndrome 1 (WMS1)

Subcellular Location

Secreted, extracellular space, extracellular matrix.

Tissue Specificity

Widely expressed in adult tissues.

Database Links

HGNC: 13201

OMIM: 277600

KEGG: hsa:81794

STRING: 9606.ENSP00000270328

UniGene: Hs.657508

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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