AGBL5 Antibody

Datasheet

Code	CSB-PA074141
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA074141(AGBL5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA074141(AGBL5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q8NDL9

Target Names

AGBL5

Alternative Names

AGBL5 antibody; ATP/GTP binding protein like 5 antibody; ATP/GTP-binding protein-like 5 antibody; CBPC5_HUMAN antibody; CCP5 antibody; Cytosolic carboxypeptidase like protein 5 antibody; Cytosolic carboxypeptidase-like protein 5 antibody; FLJ21839 antibody; Hypothetical protein FLJ21839 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Fusion protein of Human AGBL5

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation.

Gene References into Functions

Homology models indicated destabilization of AGBL5 due to the p.Arg281Cys change. PMID: 27764769
The identification of AGBL5 and TTLL5, a previously described RP-associated gene encoding the tubulin tyrosine ligase-like family, member 5 protein, highlights the importance of poly- and deglutamylation in retinal homeostasis. PMID: 27842159
Due to the characteristic Retinitis Pigmentosa phenotype in patients carrying the AGBL5 missense mutation we suggest this gene as a candidate for a new form of autosomal recessively inherited RP PMID: 26720455

Involvement in disease

Retinitis pigmentosa 75 (RP75)

Subcellular Location

Cytoplasm, cytosol. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.

Protein Families

Peptidase M14 family

Tissue Specificity

Expressed in brain.

Database Links

HGNC: 26147

OMIM: 615900

KEGG: hsa:60509

STRING: 9606.ENSP00000353249

UniGene: Hs.138207

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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