ANLN Antibody

1. Bladder urothelial carcinoma patients with elevated ANLN expression had poorer survival prospects. PMID: 28600503
2. Knockdown of ANLN in liver cells blocks cytokinesis and inhibits development of liver tumors. PMID: 29274368
3. Authors found that decreasing Ran-GTP levels or tethering active Ran to the equatorial membrane affects anillin's localization and causes cytokinesis phenotypes. PMID: 28931593
4. Anillin (ANLN) expression in tumor cells is correlated to poor prognosis in breast cancer patients, independent of Ki-67 or tumor size. PMID: 27863473
5. S635 phosphorylation is essential for cytokinesis. PMID: 28081137
6. ANLN expression is elevated in colorectal cancer and has a strong potential to act as a biomarker for the prognosis of colorectal cancer. PMID: 27062703
7. Findings indicate that miR-497 is a potent tumor suppressor that inhibits cancer phenotypes by targeting ANLN and HSPA4L in NPC. PMID: 26486082
8. High nuclear expression of anillin (ANLN) is an independent predictor of poor disease-specific survival and it is a useful prognostic marker of urothelial carcinoma of the upper urinary tract (UCUT). PMID: 26135313
9. Data suggest that anillin (ANLN) could be involved in breast cancer progression and a potential target candidate in breast cancer. PMID: 25223638
10. Identification 4 novel and 18 known exonic ANLN variants associated with carotid intima-media thickness at bifurcation. PMID: 26319989
11. Anillin regulates intercellular adhesion in model human epithelia by mechanisms involving the suppression of JNK activity and controlling the assembly of the perijunctional cytoskeleton. PMID: 25809162
12. The sequestration of anillin by astral microtubules might alter the organization of cortical proteins to polarize cells for cytokinesis PMID: 24994938
13. these data demonstrate that a complex of p190RhoGAP-A and anillin modulates RhoA-GTP levels in the cytokinetic furrow to ensure progression of cytokinesis. PMID: 25359885
14. Identified a missense mutation R431C in anillin (ANLN), an F-actin binding cell cycle gene, as a cause of FSGS. We screened 250 additional families with FSGS and found another variant, G618C, that segregates with disease in a second family with FSGS. PMID: 24676636
15. ANLN is positively associated with Wnt/beta-catenin signaling in gastric cancer.Elevated expression of ANLN is a predictor of intestinal type gastric cancer. ER-alpha is negatively associated with the expression of ANLN in gastric cancer. PMID: 24809965
16. Supervillin concentrates activated and total myosin II at the furrow, and simultaneous knockdown of supervillin and anillin additively increases cell division failure. PMID: 24088567
17. Antibody screening revealed 3 candidate prognostic markers in breast cancer: the Anillin (ANLN); PDZ-Binding Kinase (PBK); and, PDZ-Domain Containing 1 (PDZK1). PMID: 23547718
18. Data supports an analogous function for the anillin-Ect2 complex in human cells and one hypothesis is that this complex has functionally replaced the Drosophila anillin-RacGAP50C complex. PMID: 22514687
19. CIT-K is capable of physically and functionally interacting with the actin-binding protein anillin. PMID: 21849473
20. Cytoplasmic anillin expression is a marker of favourable prognosis in renal cell carcinoma patients. PMID: 21109967
21. This study was to establish if ANLN was a molecular marker for pancreatic cancer. PMID: 19995712
22. anillin has a role in spatially regulating the contractile activity of myosin II during cytokinesis PMID: 15496454
23. Anillin is a substrate of APC/C that controls spatial contractility of myosin during late cytokinesis. PMID: 16040610
24. anillin is overexpressed in diverse common human tumors, but not simply because of its role in cell proliferation PMID: 16203764
25. Over-expression of ANLN is associated with pulmonary carcinogenesis PMID: 16357138
26. Human anillin contains a conserved C-terminal domain that is essential for its function and localization. PMID: 18158243

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HGNC: 14082

OMIM: 616027

KEGG: hsa:54443

STRING: 9606.ENSP00000265748

UniGene: Hs.62180